RESUMO
OBJECTIVES: We investigated the efficacy and safety of tacrolimus (TAC) by monitoring its serum concentration for mothers and infants in pregnant patients with systemic lupus erythematosus (SLE). METHODS: We measured trough concentrations of TAC in 25 pregnant patients with SLE to assess influence of TAC on the disease activity. Additionally, we measured the concentrations of TAC in umbilical arterial blood, breast milk, and breastfed infants to investigate the safety of TAC for the mothers and infants. RESULTS: The trough concentrations of TAC in the mothers significantly decreased in the second trimester as compared with those before pregnancy. However, the decrease in the trough concentrations of TAC did not lead to the deterioration of SLE. When examined, the doses of TAC were significantly lower in the second trimester and postpartum in the deteriorating group than those in the non-deteriorating group. There were no adverse events by TAC in mothers and fetuses. The concentrations of TAC in the umbilical cord blood were lower than those in the maternal blood. The relative infant dose in breastfed infants of TAC was < 1%. The level of TAC in infant bloods was below detectable limits. CONCLUSION: These findings suggest that TAC is one of the most effective and safest immunosuppressive drugs for use in pregnant patients with SLE.
Assuntos
Imunossupressores/uso terapêutico , Lactação , Lúpus Eritematoso Sistêmico/tratamento farmacológico , Tacrolimo/uso terapêutico , Adulto , Aleitamento Materno , Feminino , Sangue Fetal/química , Humanos , Imunossupressores/sangue , Lactente , Recém-Nascido , Japão , Leite Humano/química , Gravidez , Índice de Gravidade de Doença , Tacrolimo/sangueRESUMO
MOTIVATION: The identification of new therapeutic uses of existing drugs, or drug repositioning, offers the possibility of faster drug development, reduced risk, lesser cost and shorter paths to approval. The advent of high throughput microarray technology has enabled comprehensive monitoring of transcriptional response associated with various disease states and drug treatments. This data can be used to characterize disease and drug effects and thereby give a measure of the association between a given drug and a disease. Several computational methods have been proposed in the literature that make use of publicly available transcriptional data to reposition drugs against diseases. METHOD: In this work, we carry out a data mining process using publicly available gene expression data sets associated with a few diseases and drugs, to identify the existing drugs that can be used to treat genes causing lung cancer and breast cancer. RESULTS: Three strong candidates for repurposing have been identified- Letrozole and GDC-0941 against lung cancer, and Ribavirin against breast cancer. Letrozole and GDC-0941 are drugs currently used in breast cancer treatment and Ribavirin is used in the treatment of Hepatitis C.
Assuntos
Biologia Computacional/métodos , Bases de Dados Genéticas , Reposicionamento de Medicamentos/métodos , Regulação Neoplásica da Expressão Gênica , Antineoplásicos/uso terapêutico , Neoplasias da Mama/tratamento farmacológico , Neoplasias da Mama/genética , Feminino , Hepatite C/genética , Humanos , Letrozol , Neoplasias Pulmonares/genética , Nitrilas/uso terapêutico , Triazóis/uso terapêuticoRESUMO
ABSTRACT At the outpatient clinic of Ain Shams University Maternity Hospital, perceptions and practices of 1000 women regarding their reproductive health rights (reproductive rights) were evaluated. The majority had positive perceptions about their rights to reproductive health; however, 30% disagreed with prohibitions of discrimination against women, particularly prohibitions of female genital mutilation (FGM). A significant association was found between perceptions of sexual rights and demographic characteristics and between education and practices regarding early detection of cancer. No significant association was found between education and concepts of adolescent health education as a reproductive right. Programmes about women's reproductive rights that emphasize the issue of sexual health through religious education are recommended as one of the best strategies for the eradication of FGM.
Assuntos
Atitude Frente a Saúde , Medicina Reprodutiva , Direitos Sexuais e Reprodutivos/psicologia , Saúde da Mulher , Direitos da Mulher , Mulheres/psicologia , Adulto , Circuncisão Feminina , Escolaridade , Egito , Serviços de Planejamento Familiar , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Acessibilidade aos Serviços de Saúde/normas , Maternidades , Hospitais Universitários , Humanos , Casamento/psicologia , Programas de Rastreamento , Avaliação das Necessidades , Ambulatório Hospitalar , Preconceito , Medicina Reprodutiva/educação , Direitos Sexuais e Reprodutivos/educação , População Rural/estatística & dados numéricos , Educação Sexual , Inquéritos e Questionários , População Urbana/estatística & dados numéricos , Mulheres/educação , Direitos da Mulher/educaçãoRESUMO
At the outpatient clinic of Ain Shams University Maternity Hospital, perceptions and practices of 1000 women regarding their reproductive health rights [reproductive rights] were evaluated. The majority had positive perceptions about their rights to reproductive health; however, 30% disagreed with prohibitions of discrimination against women, particularly prohibitions of female genital mutilation [FGM]. A significant association was found between perceptions of sexual rights and demographic characteristics and between education and practices regarding early detection of cancer. No significant association was found between education and concepts of adolescent health education as a reproductive right. Programmes about women's reproductive rights that emphasize the issue of sexual health through religious education are recommended as one of the best strategies for the eradication of FGM