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1.
Cardiol Young ; 32(12): 1952-1956, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-35152927

RESUMO

BACKGROUND: Recurrent laryngeal nerve injury leading to vocal cord paralysis is a known complication of cardiothoracic surgery. Its occurrence during interventional catheterisation procedures has been documented in case reports, but there have been no studies to determine an incidence. OBJECTIVE: To establish the incidence of left recurrent laryngeal nerve injury leading to vocal cord paralysis after left pulmonary artery stenting, patent ductus arteriosus device closure and the combination of the procedures either consecutively or simultaneously. METHODS: Members of the Congenital Cardiovascular Interventional Study Consortium were asked to perform a retrospective analysis to identify cases of recurrent laryngeal nerve injury after the aforementioned procedures. Twelve institutions participated in the analysis. They also contributed the total number of each procedure performed at their respective institutions for statistical purposes. RESULTS: Of the 1337 patients who underwent left pulmonary artery stent placement, six patients (0.45%) had confirmed vocal cord paralysis. 4001 patients underwent patent ductus arteriosus device closure, and two patients (0.05%) developed left vocal cord paralysis. Patients who underwent both left pulmonary artery stent placement and patent ductus arteriosus device closure had the highest incidence of vocal cord paralysis which occurred in 4 of the 26 patients (15.4%). Overall, 92% of affected patients in our study population had resolution of symptoms. CONCLUSION: Recurrent laryngeal nerve injury is a rare complication of left pulmonary artery stent placement or patent ductus arteriosus device closure. However, the incidence is highest in patients undergoing both procedures either consecutively or simultaneously. Additional research is necessary to determine contributing factors that might reduce the risk of recurrent laryngeal nerve injury.


Assuntos
Permeabilidade do Canal Arterial , Traumatismos do Nervo Laríngeo Recorrente , Paralisia das Pregas Vocais , Humanos , Traumatismos do Nervo Laríngeo Recorrente/etiologia , Traumatismos do Nervo Laríngeo Recorrente/complicações , Paralisia das Pregas Vocais/epidemiologia , Paralisia das Pregas Vocais/etiologia , Permeabilidade do Canal Arterial/epidemiologia , Permeabilidade do Canal Arterial/cirurgia , Permeabilidade do Canal Arterial/complicações , Incidência , Estudos Retrospectivos , Cateterismo/efeitos adversos
2.
Expert Opin Ther Targets ; 11(5): 589-99, 2007 May.
Artigo em Inglês | MEDLINE | ID: mdl-17465719

RESUMO

Cells require the ability to appropriately respond to signals in their extracellular environment. To initiate, inhibit and control these processes, the cell has developed a complex network of signaling cascades. The phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling pathways regulate several responses including mitosis, apoptosis, motility, proliferation, differentiation and many others. It is not surprising, therefore, that many viruses target the PI3K and MAPK pathways as a means to manipulate cellular function. Recently, Kaposi's sarcoma-associated herpes virus (KSHV) has been added to the list. KSHV manipulates the PI3K and MAPK pathways to control such divergent processes as cell survival, cellular migration, immune responses, and to control its own reactivation and lytic replication. Manipulation of the PI3K and MAPK pathways also plays a role in malignant transformation. Here, the authors review the potential to target the PI3K and MAPK signaling pathways to inhibit KSHV infection and pathogenesis.


Assuntos
Antivirais/uso terapêutico , Sistemas de Liberação de Medicamentos , Infecções por Herpesviridae/tratamento farmacológico , Herpesvirus Humano 8/patogenicidade , Sistema de Sinalização das MAP Quinases/efeitos dos fármacos , Inibidores de Fosfoinositídeo-3 Quinase , Inibidores de Proteínas Quinases/uso terapêutico , Sarcoma de Kaposi/prevenção & controle , Transdução de Sinais/efeitos dos fármacos , Infecções Tumorais por Vírus/tratamento farmacológico , Síndrome da Imunodeficiência Adquirida/complicações , Adolescente , Adulto , Antivirais/farmacologia , Criança , Regulação Viral da Expressão Gênica , Herpesvirus Humano 8/fisiologia , Humanos , Sistema de Sinalização das MAP Quinases/fisiologia , Neovascularização Patológica/tratamento farmacológico , Fosfatidilinositol 3-Quinases/fisiologia , Inibidores de Proteínas Quinases/farmacologia , Sarcoma de Kaposi/etiologia , Transdução de Sinais/fisiologia , Ativação Viral , Latência Viral , Quinases raf/antagonistas & inibidores , Quinases raf/fisiologia
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