[68Ga]Ga-FAP-2286, a novel promising theragnostic approach for PET/CT imaging in patients with various type of metastatic cancers.

BACKGROUND: Fibroblast activation protein (FAP) has emerged as a promising target for diagnosis and therapeutic intervention due to high expression and accumulation in the stromal compartments of a variety of malignant tumors. FAP-2286 utilizes cyclic peptides with FAP-binding characteristics to enhance the retention of the imaging agent within tumors, in contrast to the small-molecule FAP inhibitors (FAPI) like FAPI-04/46. The aim of this study was to quantify the tumor uptake of [68Ga] Gallium-FAP-2286 within primary solid tumors, adjacent excised tissues, and metastatic lesions. METHODS: In this prospective study, 21 patients (average age 51.9) with various diagnoses of remaining and metastatic cancers participated. Among them, six had metastatic sarcoma, and 14 had adenocarcinoma, including eight breast, two rectum, two lung, two pancreas, and one thyroid cases. The patients underwent a [68Ga]Ga-FAP-2286 PET/CT scan. An hour post-administration of [68Ga]Ga-FAP-2286, a visual assessment of whole body scans and semi-quantification of the PET/CT results were carried out. The standardized uptake values (SUV)max of [68Ga]Ga-FAP-2286 in tumor lesions and the tumor-to-background ratio (TBR) were then calculated. RESULTS: The vital signs of the patients, such as heart rate, blood pressure, and temperature, were observed before, during, and after the diagnostic procedure during the 4-h follow-up. All individuals underwent the [68Ga]Ga-FAP-2286 PET/CT scans without any signs of drug-associated pharmacological effects. The PET/CT scans displayed substantial absorption of [68Ga]Ga-FAP-2286 in tumor lesions in all patients (100% (21/21)). Irrespective of the tumors' origins (epithelial or mesothelium) and whether they exhibited local recurrence, distant recurrence, or metastatic lesions, the PET/CT scans revealed the uptake of [68Ga]Ga-FAP-2286 in these lesions. CONCLUSION: Overall, these data suggest that [68Ga]Ga-FAP-2286 is a promising FAP derivative for efficient metastatic cancer diagnosis and being considered as a potential compound for therapeutic application in patients with advanced metastatic cancers.

Sonochemical synthesis of polyoxometalate based of ionic crystal nanostructure: A photocatalyst for degradation of 2,4-dichlorophenol.

Single crystals of new polyoxometalate based ionic crystal [Fe(phen)3]2[SiW12O40]·3DMF (IC-Fe), (phen=1,10-phenanthroline, DMF=N,N-dimethylformamide) and their nanoparticles (IC-Fe-NPs) have been synthesized via self-assembly of constituent ions and sonochemical reaction, respectively. All materials have been characterized by field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), thermal gravimetric (TG), powder X-ray diffraction (PXRD), FT-IR spectroscopy and elemental analyses. Effect of sonication conditions on size and morphology of IC-Fe was investigated including time, concentrations of initial reagents and power of irradiation. Further studies have shown that IC-Fe is not only active in photocatalytic degradation of 2,4-dichlorophenol under visible light irradiation, but also is very stable in the various solvents and it can be easily separated and reused for cycles of reaction.