1.
Pediatr Blood Cancer
; 68(1): e28553, 2021 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32672397
Assuntos
Deleção Cromossômica , Cromossomos Humanos Par 13/genética , Doença de Hirschsprung/patologia , Retinoblastoma/patologia , Síndrome de Waardenburg/patologia , Feminino , Doença de Hirschsprung/complicações , Doença de Hirschsprung/genética , Humanos , Lactente , Prognóstico , Retinoblastoma/complicações , Retinoblastoma/genética , Síndrome de Waardenburg/complicações , Síndrome de Waardenburg/genética
2.
Indian J Ophthalmol
; 69(8): 2111-2115, 2021 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34304188
RESUMO
Purpose: This study is aimed to investigate the presence of Human papillomavirus (HPV) DNA in tumors obtained from sporadic retinoblastoma patients. Methods: One hundred six tumor tissues obtained from sporadic RB patients were analyzed for HPV infection by use of both seminested PCR and real-time quantitative PCR. Results: Of 106 RB patients, 55 were male and 51 were female. The mean age at diagnosis was 26.77 ± 15.36 (mean ± Std. dev) months. Almost all patients presented with leukocoria. Molecular investigation by different methods revealed no HPV positivity in any tumor genome. Conclusion: Our study demonstrates no association between HPV and RB, postulating HPV may not be a major risk factor in the etiology of RB.