RESUMO
Translating scientific findings from English to other native languages is essential to make sure that they can be integrated into timely and informed dialogue with policymakers and a diverse range of audiences who are affected by the science. Here, we present innovative approaches how to enhance access to scientific knowledge in non-English languages.
Assuntos
Idioma , Tradução , Conhecimento , CiênciaRESUMO
Predicting the temporal and spatial patterns of South Asian monsoon rainfall within a season is of critical importance due to its impact on agriculture, water availability, and flooding. The monsoon intraseasonal oscillation (MISO) is a robust northward-propagating mode that determines the active and break phases of the monsoon and much of the regional distribution of rainfall. However, dynamical atmospheric forecast models predict this mode poorly. Data-driven methods for MISO prediction have shown more skill, but only predict the portion of the rainfall corresponding to MISO rather than the full rainfall signal. Here, we combine state-of-the-art ensemble precipitation forecasts from a high-resolution atmospheric model with data-driven forecasts of MISO. The ensemble members of the detailed atmospheric model are projected onto a lower-dimensional subspace corresponding to the MISO dynamics and are then weighted according to their distance from the data-driven MISO forecast in this subspace. We thereby achieve improvements in rainfall forecasts over India, as well as the broader monsoon region, at 10- to 30-d lead times, an interval that is generally considered to be a predictability gap. The temporal correlation of rainfall forecasts is improved by up to 0.28 in this time range. Our results demonstrate the potential of leveraging the predictability of intraseasonal oscillations to improve extended-range forecasts; more generally, they point toward a future of combining dynamical and data-driven forecasts for Earth system prediction.
RESUMO
Microvascular inflammation (MVI) is a key diagnostic feature of antibody-mediated rejection (AMR), however recipients without donor specific antibodies (DSA) defy etiological classification using C4dptc and conventional DSA assignment. We evaluated MVI≥2 (Banff g+ptc≥2) using Banff 2019 AMR (independent of MVI≥2 but including C4dptc) with unconventional glomerular capillary (C4dglom) and arterial/endothelial (C4dart) immunoperoxidase detection, shared-eplet and subthreshold DSA (MFI 100-499), and capillary ultrastructure from 3398 kidney transplant samples for evidence of AMR. MVI≥2 (n=202 biopsies) from 149 kidneys (12.4% prevalence) correlated with DSA+, C4dptc+, C4dglom+, Banff cg, i, t, ti scores, serum creatinine, proteinuria, and graft failure compared with 202 propensity score matched normal controls. Laboratory reported DSA- MVI≥2 (MFI≥500) occurred in 34.7%, however subthreshold (28.6%), eplet-directed (51.4%), and/or misclassified anti-HLA DSA (12.9%) were identified in 67.1% by forensic reanalysis, with vascular C4d+ staining in 67.1%, and endothelial abnormalities in 57.1%, totalling 87.1%. Etiological analysis attributed 62.9% to AMR (77.8% for DSA- MVI≥2 with glomerulitis) and pure T cellular rejection is 37.1%. C4dptc-DSA- MVI≥2 was unrecognized AMR in 48.0%. Functional outcomes and graft survival were comparable to normal controls. We concluded that DSA- MVI≥2 frequently signified a mild "borderline" phenotype of AMR which was recognizable using novel serological and pathological techniques.
RESUMO
AIM: Hepatic angiography procedures are essential in the treatment of hepatocellular carcinoma (HCC), with traditional transfemoral arterial (TFA) access being the traditional standard. Recently, transradial arterial (TRA) access has gained popularity, offering potential benefits. This study aims to conduct a systematic review and meta-analysis to compare TRA and TFA access in hepatic angiography oncologic procedures for HCC. The study investigates fluoroscopy time, radiation dose, patient preferences, and complications associated with each access method. MATERIAL AND METHODS: A systematic review was performed using PRISMA guidelines, with 11 studies encompassing 2535 HCC procedures included. Statistical analysis was conducted using RevMan 5.4 software. Continuous outcomes were calculated as mean differences, and binary outcomes were measured as odds ratios. Patient preferences, procedural complications, and access site success rates were assessed. RESULTS: The meta-analysis revealed that there were no significant differences in fluoroscopy time, radiation dose, or contrast dose between TRA and TFA. Access failure rates were similar for both methods. However, the odds of adverse events, excluding access failure, were significantly higher for TFA, while the overall rate of complications was comparable. Patients strongly preferred TRA over TFA due to reduced hospital stay and post-procedure discomfort. CONCLUSION: This meta-analysis supports the use of TRA for hepatic angiography oncologic procedures for HCC with patient preferences in favor of TRA. Additional randomized clinical trials are encouraged to further evaluate the feasibility and benefits of both access sites.
RESUMO
Symptomatic women with angina are more likely to have ischemia with no obstructive coronary arteries (INOCA) compared to men. In both men and women, the finding of INOCA is not benign and is associated with adverse cardiovascular events, including myocardial infarction, heart failure and angina hospitalizations. Women with INOCA have more angina and a lower quality of life compared to men, but they are often falsely reassured because of a lack of obstructive coronary artery disease (CAD) and a perception of low risk. Coronary microvascular dysfunction (CMD) is a key pathophysiologic contributor to INOCA, and non-invasive imaging methods are used to detect impaired microvascular flow. Coronary vasospasm is another mechanism of INOCA, and can co-exist with CMD, but usually requires invasive coronary function testing (CFT) with provocation testing for a definitive diagnosis. In addition to traditional heart disease risk factors, inflammatory, hormonal and psychological risk factors that impact microvascular tone are implicated in INOCA. Treatment of risk factors and use of anti-atherosclerotic and anti-anginal medications offer benefit. Increasing awareness and early referral to specialized centers that focus on INOCA management can improve patient-oriented outcomes. However, large, randomized treatment trials to investigate the impact on major adverse cardiovascular events (MACE) are needed. In this focused review, we discuss the prevalence, pathophysiology, presentation, diagnosis and treatment of INOCA.
Assuntos
Doença da Artéria Coronariana , Isquemia Miocárdica , Masculino , Feminino , Humanos , Doença da Artéria Coronariana/diagnóstico , Qualidade de Vida , Isquemia Miocárdica/diagnóstico , Isquemia Miocárdica/etiologia , Isquemia Miocárdica/tratamento farmacológico , Vasos Coronários , IsquemiaRESUMO
BACKGROUND: Faecal incontinence (FI) is common, with a significant impact on quality of life. Percutaneous tibial nerve stimulation (PTNS) is a therapy for FI; however, its role has recently been questioned. Here we report the short-term clinical and manometric outcomes in a large tertiary centre. METHODS: A retrospective review of a prospective PTNS database was performed, extracting patient-reported FI outcome measures including bowel diary, the St Marks's Incontinence Score (SMIS) and Manchester Health Questionnaire (MHQ). Successful treatment was > 50% improvement in symptoms, whilst a partial response was 25-50% improvement. High-resolution anorectal manometry (HRAM) results before and after PTNS were recorded. RESULTS: Data were available from 135 patients [119 (88%) females; median age: 60 years (range: 27-82years)]. Overall, patients reported a reduction in urge FI (2.5-1) and passive FI episodes (2-1.5; p < 0.05) alongside a reduction in SMIS (16.5-14) and MHQ (517.5-460.0; p < 0.001). Some 76 (56%) patients reported success, whilst a further 20 (15%) reported a partial response. There were statistically significant reductions in rectal balloon thresholds and an increase in incremental squeeze pressure; however, these changes were independent of treatment success. CONCLUSION: Patients report PTNS improves FI symptoms in the short term. Despite this improvement, changes in HRAM parameters were independent of this success. HRAM may be unable to measure the clinical effect of PTNS, or there remains the possibility of a placebo effect. Further work is required to define the role of PTNS in the treatment of FI.
Assuntos
Incontinência Fecal , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Incontinência Fecal/terapia , Manometria , Estudos Prospectivos , Qualidade de Vida , Nervo Tibial , Adulto , Idoso , Idoso de 80 Anos ou maisRESUMO
The objective of this study was to analyze the diverse morphological attributes of Kotdhar goat native to Shivalik hill region of Himachal Pradesh. A total number of 180 goats, comprising 150 females and 30 males aged between 1 and 3 years, were randomly selected to estimate15 distinct morphological traits and ten body indices. Mean values of 17.66 cm, 11.68 cm, 8.73 cm, 71.94 cm, 69.83 cm, 74.48 cm, 38.10 cm, 73.38 cm, 20.55 cm, 16.48 cm, 14.89 cm, 13.57 cm, 19.20 cm, 7.71 cm and 26.12 kg were estimated for head length, head width, face length, body length, wither height, heart girth, chest depth, rump height, rump length, rump width, haunch width, bicoastal width, shoulder width, cannon bone and body weight respectively. In addition, morphological indices viz. body index, length index, body ratio, thoracic development, pelvic index, longitudinal pelvic index, transverse pelvic index, proportionality index, dactyl thorax index and relative depth of thorax were estimated from morphological traits. Results of morphological indices indicated that Kotdhar goat are medium bodied, longilinear, tall animals and well-suited for meat production. Phenotypic correlation among most of traits was positive and significant. Among all correlations, correlation between head length and head width was found lowest (- 0.270), while the correlation between heart girth and chest depth was observed highest (0.861). Canonical discriminant function analysis showed that there was no considerable level of intermixing for morphological traits in Kotdhar goat. Employing principal component analysis with varimax rotation, three principal components were observed, accounting for 68.47% of the total variation. First principal component (PC1) encapsulated the highest proportion of variance (44.39), revealing the high loadings on head length (0.777), body length (0.747), wither height (0.782), heart girth (0.785), chest depth (0.706), rump height (0.762), haunch width (0.734) and bicoastal width (0.793). Hence, it is possible to utilize these eight variables out of the 15 morphological traits for the characterization of the Kotdhar goat.
Assuntos
Cabras , Masculino , Feminino , Animais , Peso Corporal , Fenótipo , Análise Discriminante , Análise de Componente PrincipalRESUMO
Background: Smoking is common in patients of depression and is known to affect response to antidepressants. This study was undertaken to evaluate the effect of smoking on the antidepressant effect of sertraline. Method: Patients with depression were divided into smoker and nonsmoker cohorts and followed up for 8 weeks. Serum sertraline levels were estimated using the high-performance liquid chromatography system. Response to treatment was evaluated with the Hamilton Depression Rating Scale (HAM-D). Results: Serum sertraline levels did not differ between smokers and nonsmokers at 4 and 8 weeks. Nonsmokers responded better to sertraline than smokers after 8 weeks. Adverse drug reaction profile did not vary between the two groups and was not impacted by serum sertraline levels. Nonsmokers showed a greater fall in the HAM-D score than smokers. Conclusion: This study found depression among smokers to be less responsive to sertraline. This was not explained by serum sertraline levels. Treatment of depression in smokers with sertraline might require higher doses and duration, with more frequent reviews.
RESUMO
Pulse beetle (Callasobruchus maculatus) is a common infestation during storage of legumes in India, and presently being managed by chemical fumigation. In the present investigation, a non-chemical method based on dielectric heating by microwaves (900 W, 2450 MHz) was studied for disinfestation of green gram at different grain layer thickness (5, 10, 15 and 20 mm) and exposure durations (0-60 s). The susceptibility (LT95) of different stages was in the order of egg (31.668 s) > grub (40.388 s) > pupa (44.176 s) > adult (49.018 s). The adult was tolerant up to 50 s (R2-0.799, P < 0.01) to microwave exposure duration without green gram, and up to 30 s (R2-0.804, P < 0.01) with green gram. Hundred percent mortality was observed at 10 mm (30 s, R2-0.969, P < 0.01) and 15 mm (30 s, R2-0.972, P < 0.01) grain layer thickness without significantly affecting grain quality. Cooking time and germination did not vary significantly up to 30 s of exposure, thereafter, reduced significantly. However, water uptake did not vary significantly up to 60 s of exposure. The microwave radiations are found effective for disinfestations of green gram without significantly affecting the grain quality.
RESUMO
Tuberculosis caused by Mycobacterium orygis was detected in 2 spotted deer from a wildlife sanctuary in western India and an Indian bison from a national park in central India. Nationwide surveillance is urgently required to clarify the epidemiology of the Mycobacterium tuberculosis complex at the human-livestock-wildlife interface.
Assuntos
Bison , Cervos , Mycobacterium bovis , Tuberculose , Humanos , Animais , Cervos/microbiologia , Tuberculose/epidemiologia , Ruminantes , Animais Selvagens , ÍndiaRESUMO
BACKGROUND: As per the guidelines of the Indian Council of Medical Research, nasopharyngeal and oropharyngeal swabs in viral transport medium (VTM) are to be stored at 4 °C for less than 5 days and for more than 5 days at -70 °C. Samples are not transported or stored as per prescribed conditions because of the limitations, resulting in an apprehensive diagnosis. The aim of the study was to test the stability of the SARS-CoV-2 sample stored in VTM at different temperatures. METHODS: In this study, the stability of 21 positive and 9 negative samples for SARS-CoV-2 was evaluated in commercial VTM at different temperatures (-80 °C, -20 °C, 4 °C, and 25 to 30 °C). Stability was checked for up to 50 days in the above storage conditions at different intervals. PathoDetect™ and Hi-PCR® kits were used for the detection of the four genes of SARS-CoV-2. The Cycle Threshold (Ct) value for determining the positivity of samples for PathoDetect™ was < 40 and for Hi-PCR® was < 38. RESULTS: The SARS-CoV-2 confirmatory genes (RdRp and E genes) and the internal housekeeping gene remained detectable even on the 50th day of the study. The Ct of the RdRp and E genes were found to increase with storage duration, but all positive samples remained positive till the end of the study, or the Ct value remained below the cut-off level. The negative samples gave consistent results until the end of the study. When the differences in Ct values were compared between the days in a set of experiments, they were not significantly different except in a few samples. CONCLUSION: The SARS-CoV-2 genetic materials in commercial VTM were stable at room temperature to -80 °C for 50 days.
Assuntos
Teste para COVID-19 , COVID-19 , Reação em Cadeia da Polimerase em Tempo Real , SARS-CoV-2 , Manejo de Espécimes , Humanos , Povo Asiático , COVID-19/diagnóstico , COVID-19/genética , COVID-19/fisiopatologia , COVID-19/virologia , Teste para COVID-19/métodos , Teste para COVID-19/normas , RNA Polimerase Dependente de RNA , SARS-CoV-2/genética , SARS-CoV-2/fisiologia , Manejo de Espécimes/métodos , Manejo de Espécimes/normasRESUMO
The rapid depletion of fossil fuels and ever-growing energy demand have led to a search for renewable clean energy sources. The storage of renewable energy calls for immediate attention to the fabrication of efficient energy storage devices like supercapacitors (SCs). As an electrode material for SCs, MnO2 has gained wide research interest because of its high theoretical capacitance, variable oxidation state, vast abundance, and low cost. However, the low electric conductivity of MnO2 limits its practical application. The conductivity of MnO2 can be enhanced by tuning the electronic states through substitution doping with cobalt. In the present work, first principles analysis based on density functional theory (DFT) has been used to examine the quantum capacitance (CQC) and surface charge (Q) of Co-doped MnO2. Doping enhanced the structural stability, electrical conductivity, potential window, and quantum capacitance of α-MnO2. The shortened band gap and localized states near the Fermi level improve the CQC of α-MnO2. For the narrow potential range (-0.4 to 0.4 V), the CQC is observed to increase with doping concentration. The highest CQC value at +0.4 V is observed to be 2412.59 µF cm-2 for Mn6Co2O16 (25% doping), five times higher than that of pristine MnO2 (471.18 µF cm-2). Mn6Co2O16 also exhibits better CQC and 'Q' at higher positive bias. Hence, it can be used as an anode material for asymmetric supercapacitors. All these results suggest better capacitive performance of Co-doped α-MnO2 for aqueous SCs and as an anode material for asymmetric supercapacitors.
RESUMO
AIM: To analyse the utility of ultrasound in assessing response to neoadjuvant chemotherapy (NAC) and predicting residual cancer burden (RCB) index and pathological complete response (pCR) MATERIALS AND METHODS: This was a retrospective study with 417 patients over 7 years. The difference in longest diameter (LD) of the index lesion from baseline to end, baseline to mid, and mid to end was evaluated with respect to RCB class using logistic regression and ordered logistic regression. RESULTS: Change in LD measurements from baseline to end, baseline to mid, and mid to end of chemotherapy as a predictor of RCB class show a negative relationship with a statistically significant association. This would suggest that a smaller change in LD measurements would be associated with an eventual higher RCB class. Change in LD measurements from baseline to end and baseline to mid chemotherapy as a predictor of pCR class show a negative relationship with a statistically significant association (p<0.05). This similarly indicates an inversely proportional relationship between changes in LD measurements and RCB class 0 for baseline to end and baseline to mid. CONCLUSION: This study has shown significance in reducing LD measurements on ultrasound as a predictor of PCR and RCB class. This adds weight to the current practice of using ultrasound at the start, mid and end of chemotherapy cycles to monitor NACT responses.
Assuntos
Neoplasias da Mama , Humanos , Feminino , Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/tratamento farmacológico , Neoplasias da Mama/patologia , Terapia Neoadjuvante , Estudos Retrospectivos , Ultrassonografia , Neoplasia Residual/patologia , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêuticoRESUMO
The probability per unit time for a thermally activated Brownian particle to escape over a potential well is, in general, well-described by Kramers's theory. Kramers showed that the escape time decreases exponentially with increasing barrier height. The dynamics slow down when the particle is charged and subjected to a Lorentz force due to an external magnetic field. This is evident via a rescaling of the diffusion coefficient entering as a prefactor in the Kramers's escape rate without any impact on the barrier-height-dependent exponent. Here, we show that the barrier height can be effectively changed when the charged particle is subjected to a vortex flow. While the vortex alone does not affect the mean escape time of the particle, when combined with a magnetic field, it effectively pushes the fluctuating particle either radially outside or inside depending on its sign relative to that of the magnetic field. In particular, the effective potential over which the particle escapes can be changed to a flat, a stable, and an unstable potential by tuning the signs and magnitudes of the vortex and the applied magnetic field. Notably, the last case corresponds to enhanced escape dynamics.
RESUMO
PURPOSE: Metformin is widely used to treat type 2 diabetes mellitus (T2DM) individuals. Clinically, inter-individual variability of metformin response is of significant concern and is under interrogation. In this study, a targeted exome and whole transcriptome analysis were performed to identify predictive biomarkers of metformin response in drug-naïve T2DM individuals. METHODS: The study followed a prospective study design. Drug-naïve T2DM individuals (n = 192) and controls (n = 223) were enrolled. T2DM individuals were administered with metformin monotherapy and defined as responders and non-responders based on their glycated haemoglobin change over three months. 146 T2DM individuals were used for the final analysis and remaining samples were lost during the follow-up. Target exome sequencing and RNA-seq was performed to analyze genetic and transcriptome profile. The selected SNPs were validated by genotyping and allele specific gene expression using the TaqMan assay. The gene prioritization, enrichment analysis, drug-gene interactions, disease-gene association, and correlation analysis were performed using various tools and databases. RESULTS: rs1050152 and rs272893 in SLC22A4 were associated with improved response to metformin. The copy number loss was observed in PPARGC1A in the non-responders. The expression analysis highlighted potential differentially expressed targets for predicting metformin response (n = 35) and T2DM (n = 14). The expression of GDF15, TWISTNB, and RPL36A genes showed a maximum correlation with the change in HbA1c levels. The disease-gene association analysis highlighted MAGI2 rs113805659 to be linked with T2DM. CONCLUSION: The results provide evidence for the genetic variations, perturbed transcriptome, allele-specific gene expression, and pathways associated with metformin drug response in T2DM.
Assuntos
Diabetes Mellitus Tipo 2 , Metformina , Humanos , Metformina/uso terapêutico , Diabetes Mellitus Tipo 2/tratamento farmacológico , Diabetes Mellitus Tipo 2/genética , Diabetes Mellitus Tipo 2/metabolismo , Hipoglicemiantes/uso terapêutico , Alelos , Estudos Prospectivos , Polimorfismo de Nucleotídeo Único , Expressão GênicaRESUMO
Some amino acids can crystallize from aqueous solution both as conglomerates and racemic compounds: under high supersaturation following rapid evaporation, dissolved amino acids draining over porous sand-bars behave like conglomerates whereas in the resulting deeper pool of water, amino acid solution switches to the more common racemic-compound system. We show how the two forms might have sequentially combined under prebiotic conditions to form the basis of homochirality. The paper is a quantitative analysis of enantiomeric excess (EE) this dual behavior of amino acids is capable of producing in tandem: Initial amplification by preferential crystallization (PC) in conglomerate system (CS) followed by further amplification in the racemic compound system (RCS). Using aspartic acid as a model system, ternary phase diagram shows that a minimum supersaturation of 1.65 is required in the CS for the solution-EE to reach its maximum value of 50% at the RCS eutectic point. A relationship is derived for the dependence of this threshold supersaturation on the eutectic solubilities of CS and RCS. For given supersaturation in CS, a relation is also derived for minimum solution-EE that must be produced by PC before CS switches to RCS. Required PC-induced threshold solution-EE of 0.194, 0.070, 0.033 is calculated for supersaturation of 2, 5, 10 respectively in aspartic acid. Switching from CS to RCS further amplifies solution-EE, resulting in an overall growth of aspartic acid solution EE from near-zero in CS to around 50% in RCS.
Assuntos
Aminoácidos , Ácido Aspártico , Aminoácidos/química , Ácido Aspártico/química , Cristalização , Estereoisomerismo , Água/químicaRESUMO
While there is consensus that Archean atmosphere was anoxic with O2 pressure, p(O2) <10-6 PAL (present atmospheric level) at sea-level, evidence suggests that p(O2) at stratospheric altitudes of 10-50 km was orders of magnitude higher, a result of photodissociation of CO2 by UVC sunlight and incomplete mixing of O2 with other gases. Molecular O2 is paramagnetic due to triplet ground state. Magnetic circular dichroism (MCD) by stratospheric O2 is examined in earth's magnetic field and shows maximum circular polarization â(I+ - I-)â at altitude of 15-30 km (I+/I- is intensity of left/right circularly polarized light). While (I+ - I-)/(I+ + I-) is small (~10-10), it is an unexplored source of enantiomeric excess (EE) by asymmetric photolysis of amino acid precursors produced in volcanic eruptions. The precursors reside in stratosphere for periods of over a year due to relative absence of vertical transport. Due to negligible thermal gradient across equator, they are trapped in the hemisphere where they are produced, with interhemispheric exchange time of over a year. The precursors diffuse through altitudes of maximum circular polarization before getting hydrolyzed on ground to amino acids. Enantiomeric excess of ~10-12 is calculated for precursors and amino acids. While small, this EE is orders of magnitude higher than predicted (~10-18) by parity violating energy differences (PVED) and could be the seed for growth of biological homochirality. Preferential crystallization (PC) is described as a plausible mechanism for amplification of solution EE of some amino acids from 10-12 to 10-2, for period of several days.
Assuntos
Aminoácidos , Oxigênio , Aminoácidos/química , Dicroísmo Circular , Estereoisomerismo , Fenômenos MagnéticosRESUMO
OBJECTIVES: This study aimed to project future temperature-associated mortality risk and additional deaths among Taiwan's elderly (aged >65 years) population. STUDY DESIGN: This study investigated retrospective temperature-mortality risk associations and future mortality projections. METHODS: A distributed lag non-linear model and random effect meta-analyses were employed to assess the risk of daily temperature-associated deaths in all-cause, circulatory, and respiratory diseases. Using the statistical downscaling temperature projections of the Representative Concentration Pathways (RCPs; i.e. RCP2.6, RCP6.0 and RCP8.5), future risk of mortalities were projected among the elderly for 2030-2039, 2060-2069 and 2090-2099, with a 30%, 40% and 50% expected increase in elderly population proportions, respectively. RESULTS: The baseline analysis from 2005 to 2018 identified that Taiwan's population is more vulnerable to cold effects than heat, with the highest cold-related mortality risk being attributed to circulatory diseases, followed by all-cause and respiratory diseases. However, future projections suggest a declining trend in cold-related mortalities and a significant rise in heat-related mortalities under different RCP scenarios. Heat-attributable mortalities under the RCP8.5 scenario by 2090-2099 would account for almost 170,360, 36,557 and 29,386 additional annual deaths among the elderly due to all-cause, circulatory and respiratory diseases, respectively. Heat-attributable all-cause mortalities among the elderly would increase by 3%, 11% and 30% under RCP2.6, RCP6.0 and RCP8.5, respectively, by 2090-2099. CONCLUSIONS: The findings of this study provide predictions on future temperature-related mortality among the elderly in a developed, ageing society with a hot and humid climate. The results from this study can guide public health interventions and policies for climate change and ageing society-associated health risks.
Assuntos
Temperatura Alta , Doenças Respiratórias , Idoso , Humanos , Temperatura , Estudos Retrospectivos , Envelhecimento , Mudança Climática , MortalidadeRESUMO
Presently, India is in the stage of installation of solar photovoltaic panels and no focus is being given towards the impending problem of handling solar waste. The absence of adequate regulations, guidelines and operational infrastructure for photovoltaic waste in the country may lead to waste being inappropriately landfilled or incinerated in a manner that may be detrimental to human health and the environment. Business as usual projection estimates 6.64 million tonnes and 5.48 million tonnes of waste generation due to the early and regular losses using the Weibull distribution function, respectively by 2040 in India. The current study also systematically investigates various policies and legislation developments on the end-of-life of photovoltaic modules in various regions of the world, to identify gaps for further assessment. Using life cycle assessment methodology, this paper compares the environmental impacts of landfilling end-of-life crystalline silicon panels with avoided burden approach due to the recycling of materials. It has been demonstrated that solar photovoltaic recycling and reusing the recovered materials will result in impact reduction in the forthcoming production phase by as high as 70%. Further, the outcomes of carbon footprint, single score indicator with the application of Intergovernmental Panel on Climate Change also predicts lower values for avoided burden approach due to recycling (15,393.96 kgCO2 eq) in comparison to landfill approach (19,844.054 kg CO2 eq). The outcomes of this study aim to illuminate the importance of the sustainable management of photovoltaic panels at end-of-life.
RESUMO
Amid COVID-19, world has gone under environmental reformation in terms of clean rivers and blue skies, whereas, generation of biomedical waste management has emerged as a big threat for the whole world, especially in the developing nations. Appropriate biomedical waste management has become a prime concern worldwide in the pandemic era of COVID-19 as it may affect environment and living organisms up to a great extent. The problem has been increased many folds because of unexpected generations of hazardous biomedical waste which needs extraordinary attentions. In this paper, the impacts and future challenges of solid waste management especially the biomedical waste management on environment and human beings have been discussed amid COVID-19 pandemic. The paper also recommends some guidelines to manage the bulk of medical wastes for the protection of human health and environment. The paper summarizes better management practices for the wastes including optimizing the decision process, infrastructure, upgrading treatment methods and other activities related with the biological disasters like COVID-19. As achieved in the past for viral disinfection, use of UV- rays with proper precautions can also be explored for COVID-19 disinfection. For biomedical waste management, thermal treatment of waste can be an alternative, as it can generate energy along with reducing waste volume by 80-95%. The Asian Development Bank observed that additional biomedical waste was generated ranged from 154 to 280 tons/day during the peak of COVID-19 pandemic in Asian megacities such as Manila, Jakarta, Wuhan, Bangkok, Hanoi, Kuala Lumpur.