Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Lck availability during thymic selection determines the recognition specificity of the T cell repertoire.

Van Laethem, François; Tikhonova, Anastasia N; Pobezinsky, Leonid A; Tai, Xuguang; Kimura, Motoko Y; Le Saout, Cécile; Guinter, Terry I; Adams, Anthony; Sharrow, Susan O; Bernhardt, Günter; Feigenbaum, Lionel; Singer, Alfred.

Cell ; 154(6): 1326-41, 2013 Sep 12.

Artigo em Inglês | MEDLINE | ID: mdl-24034254

2.

Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function.

Pobezinsky, Leonid A; Etzensperger, Ruth; Jeurling, Susanna; Alag, Amala; Kadakia, Tejas; McCaughtry, Tom M; Kimura, Motoko Y; Sharrow, Susan O; Guinter, Terry I; Feigenbaum, Lionel; Singer, Alfred.

Nat Immunol ; 16(5): 517-24, 2015 May.

Artigo em Inglês | MEDLINE | ID: mdl-25848867

3.

Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.

Sarafova, Sophia D; Van Laethem, Francois; Adoro, Stanley; Guinter, Terry; Sharrow, Susan O; Feigenbaum, Lionel; Singer, Alfred.

Immunity ; 31(3): 480-90, 2009 Sep 18.

Artigo em Inglês | MEDLINE | ID: mdl-19747858

4.

T cell-B cell thymic cross-talk: maintenance and function of thymic B cells requires cognate CD40-CD40 ligand interaction.

Fujihara, Chiharu; Williams, Joy A; Watanabe, Masashi; Jeon, Hyein; Sharrow, Susan O; Hodes, Richard J.

J Immunol ; 193(11): 5534-44, 2014 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-25344473

5.

Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.

Williams, Joy A; Zhang, Jingjing; Jeon, Hyein; Nitta, Takeshi; Ohigashi, Izumi; Klug, David; Kruhlak, Michael J; Choudhury, Baishakhi; Sharrow, Susan O; Granger, Larry; Adams, Anthony; Eckhaus, Michael A; Jenkinson, S Rhiannon; Richie, Ellen R; Gress, Ronald E; Takahama, Yousuke; Hodes, Richard J.

J Immunol ; 192(2): 630-40, 2014 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-24337745

6.

Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.

Tai, Xuguang; Van Laethem, François; Pobezinsky, Leonid; Guinter, Terry; Sharrow, Susan O; Adams, Anthony; Granger, Larry; Kruhlak, Michael; Lindsten, Tullia; Thompson, Craig B; Feigenbaum, Lionel; Singer, Alfred.

Blood ; 119(22): 5155-63, 2012 May 31.

Artigo em Inglês | MEDLINE | ID: mdl-22403258

7.

Pillars Article: Coreceptor Reversal in the Thymus: Signaled CD4+8+ Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8+ T Cells. Immunity. 2000. 13: 59-71.

Brugnera, Enrico; Bhandoola, Avinash; Cibotti, Ricardo; Yu, Qing; Guinter, Terry I; Yamashita, Yoshio; Sharrow, Susan O; Singer, Alfred.

J Immunol ; 196(5): 1985-97, 2016 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-26896482

8.

Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells.

Bosselut, Remy; Guinter, Terry I; Sharrow, Susan O; Singer, Alfred.

J Exp Med ; 197(12): 1709-19, 2003 Jun 16.

Artigo em Inglês | MEDLINE | ID: mdl-12810689

9.

In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells.

Yu, Qing; Erman, Batu; Bhandoola, Avinash; Sharrow, Susan O; Singer, Alfred.

J Exp Med ; 197(4): 475-87, 2003 Feb 17.

Artigo em Inglês | MEDLINE | ID: mdl-12591905

10.

Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.

Van Laethem, François; Sarafova, Sophia D; Park, Jung-Hyun; Tai, Xuguang; Pobezinsky, Leonid; Guinter, Terry I; Adoro, Stanley; Adams, Anthony; Sharrow, Susan O; Feigenbaum, Lionel; Singer, Alfred.

Immunity ; 27(5): 735-50, 2007 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-18023370

11.

Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model.

Erman, Batu; Alag, Amala S; Dahle, Oyvind; van Laethem, François; Sarafova, Sophia D; Guinter, Terry I; Sharrow, Susan O; Grinberg, Alexander; Love, Paul E; Singer, Alfred.

J Immunol ; 177(10): 6613-25, 2006 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-17082573

12.

Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity.

Sarafova, Sophia D; Erman, Batu; Yu, Qing; Van Laethem, François; Guinter, Terry; Sharrow, Susan O; Feigenbaum, Lionel; Wildt, Kathryn F; Ellmeier, Wilfried; Singer, Alfred.

Immunity ; 23(1): 75-87, 2005 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-16039581

13.

Overview of flow cytometry.

Sharrow, Susan O.

Curr Protoc Immunol ; Chapter 5: 5.1.1-5.1.8, 2002 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-18432884

14.

CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes.

Williams, Joy A; Sharrow, Susan O; Adams, Anthony J; Hodes, Richard J.

J Immunol ; 168(6): 2759-65, 2002 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-11884443

15.

Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function.

Chu, Yu-Waye; Memon, Sarfraz A; Sharrow, Susan O; Hakim, Frances T; Eckhaus, Michael; Lucas, Philip J; Gress, Ronald E.

Blood ; 104(4): 1110-9, 2004 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-15130942

16.

A dose effect of IL-7 on thymocyte development.

El Kassar, Nahed; Lucas, Philip J; Klug, David B; Zamisch, Monica; Merchant, Melinda; Bare, Catherine V; Choudhury, Baishakhi; Sharrow, Susan O; Richie, Ellen; Mackall, Crystal L; Gress, Ronald E.

Blood ; 104(5): 1419-27, 2004 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-15155461

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