Real-World Effectiveness of BNT162b2 Against Infection and Severe Diseases in Children and Adolescents.

BACKGROUND: The efficacy of the BNT162b2 vaccine in pediatrics was assessed by randomized trials before the Omicron variant's emergence. The long-term durability of vaccine protection in this population during the Omicron period remains limited. OBJECTIVE: To assess the effectiveness of BNT162b2 in preventing infection and severe diseases with various strains of the SARS-CoV-2 virus in previously uninfected children and adolescents. DESIGN: Comparative effectiveness research accounting for underreported vaccination in 3 study cohorts: adolescents (12 to 20 years) during the Delta phase and children (5 to 11 years) and adolescents (12 to 20 years) during the Omicron phase. SETTING: A national collaboration of pediatric health systems (PEDSnet). PARTICIPANTS: 77 392 adolescents (45 007 vaccinated) during the Delta phase and 111 539 children (50 398 vaccinated) and 56 080 adolescents (21 180 vaccinated) during the Omicron phase. INTERVENTION: First dose of the BNT162b2 vaccine versus no receipt of COVID-19 vaccine. MEASUREMENTS: Outcomes of interest include documented infection, COVID-19 illness severity, admission to an intensive care unit (ICU), and cardiac complications. The effectiveness was reported as (1-relative risk)*100, with confounders balanced via propensity score stratification. RESULTS: During the Delta period, the estimated effectiveness of the BNT162b2 vaccine was 98.4% (95% CI, 98.1% to 98.7%) against documented infection among adolescents, with no statistically significant waning after receipt of the first dose. An analysis of cardiac complications did not suggest a statistically significant difference between vaccinated and unvaccinated groups. During the Omicron period, the effectiveness against documented infection among children was estimated to be 74.3% (CI, 72.2% to 76.2%). Higher levels of effectiveness were seen against moderate or severe COVID-19 (75.5% [CI, 69.0% to 81.0%]) and ICU admission with COVID-19 (84.9% [CI, 64.8% to 93.5%]). Among adolescents, the effectiveness against documented Omicron infection was 85.5% (CI, 83.8% to 87.1%), with 84.8% (CI, 77.3% to 89.9%) against moderate or severe COVID-19, and 91.5% (CI, 69.5% to 97.6%) against ICU admission with COVID-19. The effectiveness of the BNT162b2 vaccine against the Omicron variant declined 4 months after the first dose and then stabilized. The analysis showed a lower risk for cardiac complications in the vaccinated group during the Omicron variant period. LIMITATION: Observational study design and potentially undocumented infection. CONCLUSION: This study suggests that BNT162b2 was effective for various COVID-19-related outcomes in children and adolescents during the Delta and Omicron periods, and there is some evidence of waning effectiveness over time. PRIMARY FUNDING SOURCE: National Institutes of Health.

Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury.

BACKGROUND: Acute lung injury (ALI) is a life-threatening respiratory condition characterized by severe inflammation and lung tissue damage, frequently causing rapid respiratory failure and long-term complications. The microRNA let-7a-5p is involved in the progression of lung injury, inflammation, and fibrosis by regulating immune cell activation and cytokine production. This study aims to use an innovative cellular electroporation platform to generate extracellular vesicles (EVs) carring let-7a-5p (EV-let-7a-5p) derived from transfected Wharton's jelly-mesenchymal stem cells (WJ-MSCs) as a potential gene therapy for ALI. METHODS: A cellular nanoporation (CNP) method was used to induce the production and release of EV-let-7a-5p from WJ-MSCs transfected with the relevant plasmid DNA. EV-let-7a-5p in the conditioned medium were isolated using a tangential flow filtration (TFF) system. EV characterization followed the minimal consensus guidelines outlined by the International Society for Extracellular Vesicles. We conducted a thorough set of therapeutic assessments, including the antifibrotic effects using a transforming growth factor beta (TGF-ß)-induced cell model, the modulation effects on macrophage polarization, and the influence of EV-let-7a-5p in a rat model of hyperoxia-induced ALI. RESULTS: The CNP platform significantly increased EV secretion from transfected WJ-MSCs, and the encapsulated let-7a-5p in engineered EVs was markedly higher than that in untreated WJ-MSCs. These EV-let-7a-5p did not influence cell proliferation and effectively mitigated the TGF-ß-induced fibrotic phenotype by downregulating SMAD2/3 phosphorylation in LL29 cells. Furthermore, EV-let-7a-5p regulated M2-like macrophage activation in an inflammatory microenvironment and significantly induced interleukin (IL)-10 secretion, demonstrating their modulatory effect on inflammation. Administering EVs from untreated WJ-MSCs slightly improved lung function and increased let-7a-5p expression in plasma in the hyperoxia-induced ALI rat model. In comparison, EV-let-7a-5p significantly reduced macrophage infiltration and collagen deposition while increasing IL-10 expression, causing a substantial improvement in lung function. CONCLUSION: This study reveals that the use of the CNP platform to stimulate and transfect WJ-MSCs could generate an abundance of let-7a-5p-enriched EVs, which underscores the therapeutic potential in countering inflammatory responses, fibrotic activation, and hyperoxia-induced lung injury. These results provide potential avenues for developing innovative therapeutic approaches for more effective interventions in ALI.

Understanding adjustment profiles among Mexican-origin adolescents over time: A focus on cultural risk and resilience factors.

This study used a three-wave longitudinal dataset to: identify adjustment profiles of U.S. Mexican-origin adolescents based on their physical, academic, and psychosocial health adjustment; track adjustment profile changes throughout adolescence; and examine the associations between cultural stressors, family obligation, and adjustment profile membership over time. Participants were 604 Mexican-origin adolescents (54% female, Mage = 12.41, SD = 0.97) in Texas (Wave 1: 2012-2015; Wave 2: 2013-2016; Wave 3: 2017-2020). Three concurrent profiles (Well-adjusted, Moderate, and Poorly-adjusted) emerged at each wave, whereas three transition profiles (Improved, Stable well-adjusted, and Overall poorly-adjusted) were identified across three waves. The results suggest that cultural stressors pose risks for Mexican-origin adolescents' adjustment, and family obligation values play a protective role in these associations.

Language brokering profiles of Mexican-origin adolescents in immigrant communities: Social-cultural contributors and developmental outcomes.

This study examines social-cultural contributors and developmental outcomes of language brokers. From 2012 to 2020, three waves of data were collected from 604 Mexican-origin adolescent language brokers (Mage = 12.92, SD = 0.92, 54% girls). The study (1) identified four distinct subgroups of language brokers (efficacious, conservative, nonchalant, and burdened) who translated for mothers and fathers, after incorporating objective bilingual proficiency along with multiple dimensions of language brokering; (2) showed that early adolescents' Mexican, rather than U.S., cultural values and orientation were related to later language brokering profiles; and (3) showed that the efficacious group was the most resilient while burdened was the most vulnerable to developmental problems. Preservation of Mexican culture may facilitate language brokering experiences related to more positive developmental outcomes.

I need new friends! Changes in perceived peer drinking norms and developmental outcomes across the transition to college.

The current study investigated changes in proximal descriptive alcohol use norms from high school to college, social integration as a predictor of stable versus shifting peer norms, and the consequences of norm profile membership for developmental outcomes. Using data (N = 9753 12th grade students; 59% female; 80% White, 7% Black, 5% Hispanic, 5% Asian/Pacific Islander, 3% other races/ethnicities) from the Monitoring the Future panel study, we identified five distinct norm profiles-three stable profiles (high, moderate-high, and low) and two shifting profiles (increasing, declining)-that had unique patterns of perceived friend alcohol use norms. Social integration distinguished norm profile membership, and we observed particular detriments to outcomes for those in the stable high peer norm profile.

Latinx adolescents' daily family assistance and emotional well-being before and amid the COVID-19 pandemic: A pilot measurement burst study.

This study examined Latinx adolescents' daily family assistance (assistance day, assistance time, language brokering) in relation to their daily affect and investigated whether the associations changed following the outbreak of the COVID-19 pandemic. Two waves of 14-day daily diary data collected from 13 18-year-old Latinx adolescents (ndays = 284; 77% Mexican American, 77% female) before and amid the pandemic were analyzed using multilevel modeling. Three main findings emerged: (1) assisting the family on a given day was associated with higher levels of same-day positive affect both before and during COVID-19, and with lower levels of negative affect during COVID-19; (2) longer than usual family assistance time was associated with higher levels of same-day positive affect and lower levels of negative affect only during COVID-19; (3) language brokering on a given day was associated with higher levels of same-day positive affect both before and during COVID-19. These findings suggest a positive link between daily family assistance and Latinx youth's daily emotional well-being, particularly during the COVID-19 pandemic.

Sociocultural Antecedents and Mechanisms of COVID-19 Vaccine Uptake among Mexican-Origin Youth.

Mexican-origin youth, as a large and growing population among U.S. youth, have been disproportionately affected by COVID-19. Understanding what, when, and how sociocultural factors may influence their COVID-19 vaccine uptake could inform current and future pandemic-response interventions promoting vaccination behaviors among Mexican-origin youth. The current study takes a developmental approach to reveal the long-term and short-term sociocultural antecedents of 198 Mexican-origin adolescents' COVID-19 vaccination uptake behaviors and explores the underlying mechanism of these associations based on the Knowledge-Attitude-Behavior model. The current study adopted Wave 1 (2012-2015) and Wave 4 (2021-2022) self-reported data from a larger study. Analyses were conducted to examine four mediation models for four sociocultural antecedents-daily discrimination, ethnic discrimination, foreigner stress, and family economic stress-separately. Consistent indirect effects of higher levels of concurrent sociocultural risk factors on a lower probability of COVID-19 vaccine uptake were observed to occur through less knowledge about the COVID-19 vaccines and less positive attitudes toward the COVID-19 vaccines at Wave 4. Significant direct effects, but in opposite directions, were found for the associations between Wave 1 ethnic discrimination/Wave 4 daily discrimination and the probability of COVID-19 vaccine uptake. The findings highlight the importance of considering prior and concurrent sociocultural antecedents and the Knowledge-Attitude-Behavior pathway leading to COVID-19 vaccination uptake among Mexican-origin youth and suggest that the impact of discrimination on COVID-19 vaccination uptake may depend on the type (e.g., daily or ethnic) and the context (e.g., during the COVID-19 pandemic or not) of discrimination experienced.

Longitudinal Relationships Among Child School Engagement, Parental Monitoring, and Child Prosocial Behavior: A Child-Parent Synergistic Mechanism.

Numerous contextual factors have been identified that impact the development of children's prosocial behavior, yet the influence of child-initiated factors on prosocial behavior and its underlying mechanism remains unclear. This study employed three longitudinal models to examine in depth how children's school engagement may promote the development of their own prosocial behavior. Three-wave longitudinal data from 4691 children (M age = 9.480, SD = 0.507; 48.2% female) with 2-year intervals were used. Sequentially, a cross-lagged panel model, a random intercept cross-lagged panel model, and a parallel process latent growth model were constructed. The findings indicated that children's school engagement consistently predicted the future level, dynamic changes at within-person level, and long-term trends in their prosocial behavior, and these longitudinal relationships were partially mediated by parental monitoring. These results reveal a child-parent synergistic mechanism for the development of prosocial behavior, wherein children's school engagement both directly promotes their own prosocial behavior and simultaneously enhances prosocial behavior through eliciting increased parental monitoring.

Daily agreeableness and acculturation processes in ethnic/racial minority freshmen: The role of inter-ethnic contact and perceived discrimination.

OBJECTIVES: Having higher levels of mainstream cultural orientation (MCO), an important component of acculturation attitudes and behaviors, is beneficial for ethnic/racial minority students during the transitions into university. Scant research has investigated MCO at a micro daily timescale. This study examined how personality (agreeableness) functions in conjunction with interpersonal processes (inter-ethnic contact and perceived discrimination) to influence MCO as daily within-person processes. METHODS: Multi-level structural equation modeling were used to analyze month-long daily diary data from 209 ethnic/racial minority freshmen (69% female). RESULTS: There was a positive indirect association between agreeableness and MCO through inter-ethnic contact at both within- and between-person levels. At the within-person level, on days with lower (vs. higher) levels of ethnic/racial discrimination, higher levels of agreeableness were associated with higher levels of MCO. CONCLUSIONS: These findings highlight the contributions of intensive longitudinal data in elucidating ethnic/racial minority students' personality and acculturation processes in daily life involving protective and risk factors on micro timescales.

Profiles of identity and discrimination and the psychological, health, and academic outcomes of Korean ethnic minority youth in China.

Korean Chinese is one of the 55 officially recognized ethnic minorities in China. The protective effects of strong bicultural (ethnic and national) identities and the detrimental effects of ethnic discrimination on adjustment outcomes are well documented for ethnic minority youth in W.E.I.R.D. societies. Yet, ethnic minority youth in non-W.E.I.R.D. societies, such as Korean Chinese, may experience a unique form of discrimination-national discrimination. It is not known how multiple social identities and experiences of dual discrimination may intersect to predict youth adjustment. Thus, this study explored profiles of ethnic and national identities and ethnic and national discrimination among Korean Chinese youth and examined their psychological, health, and academic adjustment. The analytic sample included 267 Korean Chinese youth aged from 12 to 18 (M = 15.21, SD = 1.65) residing in Northeast China. Three latent profiles were identified. The dominant profile of Korean Chinese youth was characterized by high bicultural identity and low ethnic and national discrimination (BILD; n = 171). The second profile was characterized by high bicultural identity and high national discrimination (BIND, n = 50). The third profile was characterized by moderate ethnic and national identities and moderate ethnic and national discrimination (MIMD, n = 46). Regression analyses found that the BILD profile showed fewer depressive symptoms compared to the BIND profile and showed better perceived physical health compared to the MIMD profile. The findings highlight strong bicultural identities as a cultural asset and discrimination-particularly national discrimination-as a contextual risk to Korean Chinese adolescents' well-being.

Perceived Parenting Discrepancy Profiles, Feelings about Language Brokering, and Internalizing Symptoms among Mexican-origin Adolescents in Immigrant Families.

While different patterns of perceived parenting discrepancy among mother-adolescent dyads have been shown to be associated with adolescent internalizing symptoms, little is known about the pathway underlying such associations, particularly among immigrant families. The current study considered one culturally salient form of mother-adolescent communication, language brokering (i.e., adolescents translating and interpreting between host and heritage languages for mothers), in order to investigate its mediating role based on two waves of longitudinal data on Mexican-origin immigrant families. Wave 1 included 604 adolescents (54% female; Mage = 12.92, SD = 0.92) and 595 mothers (Mage = 38.89, SD = 5.74); Wave 2 was collected one year later with data from 483 adolescents. Perceived parenting discrepancy patterns at Wave 1 were captured by three profiles based on the levels of both mothers' and adolescents' perceived positive parenting (i.e., Mother High, Adolescent High, and Both High). Compared to the other two profiles, adolescents who reported much lower positive parenting than mothers at Wave 1 (i.e., Mother High) experienced more negative feelings about brokering at Wave 2, relating to more anxiety. Being in the Mother High (vs. Both High) group was also directly related to more depressive symptoms one year later. This study highlights the importance of considering culturally salient forms of communication, such as language brokering, when designing family-level interventions to reduce adolescents' internalizing symptoms by building agreement on high positive parenting among mother-adolescent dyads from immigrant families.

Parental Academic Socialization and Youth Adjustments: A Comparison of Korean Youth in South Korea, China, and the United States.

Although parental academic socialization may be a product of culture, ethnic/racial minority status may play a significant role, above and beyond the impact of culture, in shaping parental academic socialization and its implications for youth adjustments. This study examined Korean youth living in South Korea (N = 524, Mage = 14.98, SD = 1.45, 50.1% female), China (N = 267, Mage = 15.24, SD = 1.66, 58.9% female), and the U.S. (N = 408, Mage = 14.76, SD = 1.91, 47.3% female) who share the same heritage culture but have different social positions (majority or minority). Korean youth as an ethnic/racial minority in the U.S. or China reported higher parental academic socialization than those in South Korea, supporting a significant role of social positions in how parents practice academic socialization. This study also found that the distinct practices of academic socialization function differently in youth adjustment. Parental commitment to education, parental involvement, and autonomy support were positively associated with youth's school engagement, but achievement-oriented psychological control was associated with more depressive symptoms and antisocial behaviors. These associations did not differ across the three samples. Some nuanced differences also emerged. Parental commitment to education was associated with higher grades in Korean Chinese (but not Korean American) youth, and achievement-oriented psychological control was associated with lower school engagement among Korean Chinese (but not South Korean) youth and higher grades among South Korean (but not Korean American) youth. These findings highlight the role of academic socialization as an adaptive strategy for ethnic/racial minorities to succeed in host societies and the generally universal role of parental academic socialization in youth adjustments.

Infrapatellar fat pad-derived mesenchymal stromal cell product for treatment of knee osteoarthritis: a first-in-human study with evaluation of the potency marker.

BACKGROUND AIMS: Infrapatellar fat pad-derived mesenchymal stromal cells (IFP-MSCs) have not yet been used in a human clinical trial. In this open-label phase 1 study, patients with knee osteoarthritis (OA) received a single intra-articular injection of autologous IFP-MSCs. Safety was assessed through physical examination of the knee joint, vital signs, laboratory tests and adverse events. Efficacy was evaluated with regard to pain and function using questionnaires, x-ray and magnetic resonance imaging (MRI). Indoleamine-2,3-dioxygenase (IDO) expression in IFP-MSCs primed with interferon gamma was used as an in vitro potency measurement in investigating the correlations of clinical outcomes. METHODS: Twelve patients with symptomatic knee OA were recruited. IFP adipose tissue was harvested from each patient's knee through surgical excision for IFP-MSC manufacturing. Cryopreserved IFP-MSCs (5 × 107 cells) were injected into the knee joint immediately after thawing. RESULTS: No significant adverse events were observed. Patients who received IFP-MSCs exhibited clinically significant pain and functional improvement at 48-week follow-up. The MRI Osteoarthritis Knee Score average was also significantly reduced from 100.2 before injection to 85.0 at 48 weeks after injection. The IDO expression of the primed IFP-MSCs of the 12 patients was correlated with clinical outcomes after injection. CONCLUSIONS: A single intra-articular injection of IFP-MSCs appears to be a safe therapy for treating knee OA and may improve disease symptoms. IDO measurement of primed IFP-MSCs has potential as a potency marker of MSC products for immunomodulatory therapy.

The Phenotypic, Psychological, and Social Interplays of Skin Color and Developmental Outcomes among Mexican-origin Adolescents: Dismantling Systems of Racism and Oppression during Adolescence: Dismantling Systems of Racism and Oppression during Adolescence.

Mexican-origin children from immigrant families are impacted by various systemic oppressions in life. The study seeks to examine how adolescents' developmental outcomes are associated with specific phenotypic, psychological, and social features of skin color, as manifested by skin tone, skin color satisfaction, and foreigner stress. By taking a holistic approach, we examine both positive and negative adjustment outcomes, including delinquency, resilience, and effortful control. Participants were 604 Mexican-origin adolescents aged between 11.08 and 15.29 (Mage = 12.91, SD = 0.92) with at least one immigrant parent. The findings highlight the harm of foreigner stress and the benefit of skin color satisfaction in Mexican-origin adolescents' development of delinquency, resilience, and effortful control, especially for those with a darker skin color.

Ethnic-Racial Socialization, Ethnic-Racial Identity, and Depressive Symptoms in Korean Adolescents in the United States and China.

The United States and China are top two receiving countries of Korean immigrants in modern history. Minority families in ethnically-racially diverse societies, such as the US and China, use various ethnic-racial socialization practices (cultural socialization, promotion of mistrust, preparation for bias) to help their children navigate the world, yet research in non-U.S. contexts is scarce. To examine the specificity versus generalizability of ethnic-racial socialization and its implications, this study compared the prevalence of ethnic-racial socialization reported by Korean American (n = 408; Mage = 14.76, SD = 1.91; 48.30% female) and Korean Chinese (n = 267; Mage = 15.24, SD = 1.66; 58.90% female) youth. Moreover, this study examined how various ethnic-racial socialization practices relate to the youth's ethnic-racial identity, and subsequently, depressive symptoms. Although Korean American youth reported more frequent ethnic-racial socialization compared to their Korean Chinese counterparts, cultural socialization (but not preparation for bias nor promotion of mistrust) had a comparable negative indirect association with depressive symptoms via ethnic-racial identity across both groups. Thus, although the rates of parental ethnic-racial socialization are context-specific, parental cultural socialization may be similarly beneficial for Korean ethnic-racial minority youth's identity development, and in turn, psychological outcomes, whether in a Western individualistic society or an Eastern collectivistic society.

Family Obligation, Parenting, and Adolescent Outcomes Among Mexican American Families.

The current study investigates how and under what conditions family obligation benefits Mexican American adolescents' adjustment. The study used two waves of data from 604 Mexican American adolescents (54.3% female, Mage.wave1 = 12.41 years, SD = 0.97) and their parents. Structural equation modeling revealed that both adolescents' and parents' sense of family obligation related to more supportive parenting (i.e., parental monitoring, warmth, and inductive reasoning), which linked to better adolescent adjustment (i.e., sense of life meaning, resilience, and grades). There were parent gender differences: Adolescents' family obligation was more strongly related to their reports of maternal (vs. paternal) parenting. The links also varied across informants for parenting: (a) individuals' sense of family obligation related only to their own perceptions of parenting and (b) there were more evident associations between adolescent-reported (vs. parent-reported) parenting and adolescent outcomes.

Life Course Transitions and Educational Trajectories: Examining Adolescents who Fall off Track Academically.

Educational interventions typically center on youth displaying early academic risk, potentially overlooking those falling off track academically later in their educational careers. The current study investigated the extent to which life course transitions experienced during adolescence were linked to falling off-track academically in high school. Data from the National Longitudinal Study of Adolescent to Adult Health (N = 4284; 53% female; Mage = 14.88) documented that 1516 students displayed no educational risk in early high school, yet 14% did not pursue 4-year college by age 24. Analyses revealed the unique life course transitions predictive of falling off-track academically (i.e., sexual intercourse, alcohol use, family transitions, residential mobility). The study's findings highlight important intervention avenues to promote adolescents' continued educational persistence.

Longitudinal profiles of acculturation and developmental outcomes among Mexican-origin adolescents from immigrant families.

Prior studies investigating the association between acculturation and adolescent adjustment have often focused on specific acculturation domains rather than examining these domains collectively in a profile typology. Here, we investigate stability and change patterns in Mexican American adolescent acculturation profiles over time, using a two-wave longitudinal dataset spanning 5 years. Using latent profile analysis, three adolescent acculturation profiles were identified at Waves 1 and 2: integrated; moderately integrated; and moderately assimilated. Using latent transition analysis, four acculturation transition profiles were identified across time: stable integrated; stable moderately integrated; progressive; and regressive. Over half of all adolescents were identified as belonging to the stable integrated and stable moderately integrated transition profiles. Adolescents classified in the stable integrated profile reported the highest levels of adjustment (academic competence and socioemotional well-being) relative to those with other transition profiles. Findings from this study contribute to a comprehensive understanding of the dynamic process of acculturation among Mexican American adolescents, and provide useful insights to inform interventions and policies aimed at improving Mexican-origin adolescents' adaption to US culture while maintaining their heritage Mexican culture.

Parent-Adolescent Acculturation Profiles and Adolescent Language Brokering Experiences in Mexican Immigrant Families.

Language brokering is a special form of interpersonal communication that is affected by the cultural and relational settings in which it occurs. The current study explores whether parent-adolescent acculturation status may influence Mexican American adolescent language brokers' translation experiences, including brokering frequency and attitudes. Using data from a two-wave longitudinal study (Nwave1 = 604; Nwave2 = 483; Mwave1.age = 12.91; 54.3% female), latent profile analyses were conducted, resulting in four mother-adolescent acculturation profiles as well as three father-adolescent profiles. The adolescent integrated-parent (moderately) separated profiles emerged as the most effective for brokers, as adolescents in this profile generally experienced more positive and less negative brokering attitudes, regardless of their brokering frequency. Parent-adolescent acculturation profiles may be a useful construct in capturing the interplay of cultural and relational settings and their effects on multifaceted language brokering experiences.

Stress of Language Brokering and Mexican American Adolescents' Adjustment: The Role of Cumulative Risk.

This study focused on early adolescents' stress of language brokering and examined the moderating role of family cumulative risk in the relation of language brokering to adjustment problems. Data came from self-reports of 604 low-income Mexican American adolescent language brokers (54% female; X ¯ age = 12.4 ; SD = 0.97; 75% born in the United States) and their parents (99% foreign-born) in central Texas. Path analyses revealed that brokering stress, but not frequency, was positively associated with adolescents' adjustment problems, including depressive symptoms, anxiety, and delinquency. We also found that the relation between stress of brokering for mothers and adolescents' depressive symptoms was stronger among families with a high cumulative risk. Further, with a high cumulative risk, adolescents exhibited delinquent behaviors regardless of the levels of stress from translating for fathers. Current findings underscore the importance of examining family contexts in assessing the consequences of language brokering for Mexican American early adolescents' well-being.