Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

The roles of Polycomb repressive complexes in mammalian development and cancer.

Piunti, Andrea; Shilatifard, Ali.

Nat Rev Mol Cell Biol ; 22(5): 326-345, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-33723438

2.

Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex.

Qu, Qianhui; Takahashi, Yoh-Hei; Yang, Yidai; Hu, Hongli; Zhang, Yan; Brunzelle, Joseph S; Couture, Jean-Francois; Shilatifard, Ali; Skiniotis, Georgios.

Cell ; 174(5): 1117-1126.e12, 2018 08 23.

Artigo em Inglês | MEDLINE | ID: mdl-30100186

3.

Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy.

Liang, Kaiwei; Smith, Edwin R; Aoi, Yuki; Stoltz, Kristen L; Katagi, Hiroaki; Woodfin, Ashley R; Rendleman, Emily J; Marshall, Stacy A; Murray, David C; Wang, Lu; Ozark, Patrick A; Mishra, Rama K; Hashizume, Rintaro; Schiltz, Gary E; Shilatifard, Ali.

Cell ; 175(3): 766-779.e17, 2018 10 18.

Artigo em Inglês | MEDLINE | ID: mdl-30340042

4.

Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia.

Liang, Kaiwei; Volk, Andrew G; Haug, Jeffrey S; Marshall, Stacy A; Woodfin, Ashley R; Bartom, Elizabeth T; Gilmore, Joshua M; Florens, Laurence; Washburn, Michael P; Sullivan, Kelly D; Espinosa, Joaquin M; Cannova, Joseph; Zhang, Jiwang; Smith, Edwin R; Crispino, John D; Shilatifard, Ali.

Cell ; 168(1-2): 59-72.e13, 2017 Jan 12.

Artigo em Inglês | MEDLINE | ID: mdl-28065413

5.

Transcriptional elongation control in developmental gene expression, aging, and disease.

Aoi, Yuki; Shilatifard, Ali.

Mol Cell ; 83(22): 3972-3999, 2023 Nov 16.

Artigo em Inglês | MEDLINE | ID: mdl-37922911

6.

Distinct layers of BRD4-PTEFb reveal bromodomain-independent function in transcriptional regulation.

Zheng, Bin; Gold, Sarah; Iwanaszko, Marta; Howard, Benjamin Charles; Wang, Lu; Shilatifard, Ali.

Mol Cell ; 83(16): 2896-2910.e4, 2023 08 17.

Artigo em Inglês | MEDLINE | ID: mdl-37442129

7.

Born to run: control of transcription elongation by RNA polymerase II.

Chen, Fei Xavier; Smith, Edwin R; Shilatifard, Ali.

Nat Rev Mol Cell Biol ; 19(7): 464-478, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29740129

8.

PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II.

Chen, Fei Xavier; Woodfin, Ashley R; Gardini, Alessandro; Rickels, Ryan A; Marshall, Stacy A; Smith, Edwin R; Shiekhattar, Ramin; Shilatifard, Ali.

Cell ; 162(5): 1003-15, 2015 Aug 27.

Artigo em Inglês | MEDLINE | ID: mdl-26279188

9.

It's a DoG-eat-DoG world-altered transcriptional mechanisms drive downstream-of-gene (DoG) transcript production.

Morgan, Marc; Shiekhattar, Ramin; Shilatifard, Ali; Lauberth, Shannon M.

Mol Cell ; 82(11): 1981-1991, 2022 06 02.

Artigo em Inglês | MEDLINE | ID: mdl-35487209

10.

PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing.

Fong, Ka-Wing; Zhao, Jonathan C; Lu, Xiaodong; Kim, Jung; Piunti, Andrea; Shilatifard, Ali; Yu, Jindan.

Mol Cell ; 82(24): 4611-4626.e7, 2022 12 15.

Artigo em Inglês | MEDLINE | ID: mdl-36476474

11.

SPT6 functions in transcriptional pause/release via PAF1C recruitment.

Aoi, Yuki; Shah, Avani P; Ganesan, Sheetal; Soliman, Shimaa H A; Cho, Byoung-Kyu; Goo, Young Ah; Kelleher, Neil L; Shilatifard, Ali.

Mol Cell ; 82(18): 3412-3423.e5, 2022 09 15.

Artigo em Inglês | MEDLINE | ID: mdl-35973425

12.

Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer.

Piunti, Andrea; Shilatifard, Ali.

Nat Rev Mol Cell Biol ; 23(6): 444, 2022 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-35534714

13.

SPT5 stabilization of promoter-proximal RNA polymerase II.

Aoi, Yuki; Takahashi, Yoh-Hei; Shah, Avani P; Iwanaszko, Marta; Rendleman, Emily J; Khan, Nabiha H; Cho, Byoung-Kyu; Goo, Young Ah; Ganesan, Sheetal; Kelleher, Neil L; Shilatifard, Ali.

Mol Cell ; 81(21): 4413-4424.e5, 2021 11 04.

Artigo em Inglês | MEDLINE | ID: mdl-34480849

14.

Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression.

Zheng, Bin; Aoi, Yuki; Shah, Avani P; Iwanaszko, Marta; Das, Siddhartha; Rendleman, Emily J; Zha, Didi; Khan, Nabiha; Smith, Edwin R; Shilatifard, Ali.

Genes Dev ; 35(3-4): 273-285, 2021 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-33446572

15.

A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer.

Morgan, Marc A J; Popova, Irina K; Vaidya, Anup; Burg, Jonathan M; Marunde, Matthew R; Rendleman, Emily J; Dumar, Zachary J; Watson, Rachel; Meiners, Matthew J; Howard, Sarah A; Khalatyan, Natalia; Vaughan, Robert M; Rothbart, Scott B; Keogh, Michael-C; Shilatifard, Ali.

Genes Dev ; 35(23-24): 1642-1656, 2021 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-34819353

16.

A histone modifier's ill-gotten copy gains.

Rickels, Ryan; Shilatifard, Ali.

Cell ; 154(3): 477-9, 2013 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-23911314

17.

The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation.

Lin, Chengqi; Garruss, Alexander S; Luo, Zhuojuan; Guo, Fengli; Shilatifard, Ali.

Cell ; 152(1-2): 144-56, 2013 Jan 17.

Artigo em Inglês | MEDLINE | ID: mdl-23273992

18.

NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release.

Aoi, Yuki; Smith, Edwin R; Shah, Avani P; Rendleman, Emily J; Marshall, Stacy A; Woodfin, Ashley R; Chen, Fei X; Shiekhattar, Ramin; Shilatifard, Ali.

Mol Cell ; 78(2): 261-274.e5, 2020 04 16.

Artigo em Inglês | MEDLINE | ID: mdl-32155413

19.

The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.

Shilatifard, Ali.

Annu Rev Biochem ; 81: 65-95, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-22663077

20.

A small UTX stabilization domain of Trr is conserved within mammalian MLL3-4/COMPASS and is sufficient to rescue loss of viability in null animals.

Rickels, Ryan; Wang, Lu; Iwanaszko, Marta; Ozark, Patrick A; Morgan, Marc A; Piunti, Andrea; Khalatyan, Natalia; Soliman, Shimaa H A; Rendleman, Emily J; Savas, Jeffrey N; Smith, Edwin R; Shilatifard, Ali.

Genes Dev ; 34(21-22): 1493-1502, 2020 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-33033055

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