Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

IRGM1 links mitochondrial quality control to autoimmunity.

Rai, Prashant; Janardhan, Kyathanahalli S; Meacham, Julie; Madenspacher, Jennifer H; Lin, Wan-Chi; Karmaus, Peer W F; Martinez, Jennifer; Li, Quan-Zhen; Yan, Mei; Zeng, Jialiu; Grinstaff, Mark W; Shirihai, Orian S; Taylor, Gregory A; Fessler, Michael B.

Nat Immunol ; 22(3): 312-321, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33510463

2.

Mitochondrial Networking in T Cell Memory.

Liesa, Marc; Shirihai, Orian S.

Cell ; 166(1): 9-10, 2016 Jun 30.

Artigo em Inglês | MEDLINE | ID: mdl-27368094

3.

Spatial mapping of mitochondrial networks and bioenergetics in lung cancer.

Han, Mingqi; Bushong, Eric A; Segawa, Mayuko; Tiard, Alexandre; Wong, Alex; Brady, Morgan R; Momcilovic, Milica; Wolf, Dane M; Zhang, Ralph; Petcherski, Anton; Madany, Matthew; Xu, Shili; Lee, Jason T; Poyurovsky, Masha V; Olszewski, Kellen; Holloway, Travis; Gomez, Adrian; John, Maie St; Dubinett, Steven M; Koehler, Carla M; Shirihai, Orian S; Stiles, Linsey; Lisberg, Aaron; Soatto, Stefano; Sadeghi, Saman; Ellisman, Mark H; Shackelford, David B.

Nature ; 615(7953): 712-719, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36922590

4.

Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies.

Acin-Perez, Rebeca; Benincá, Cristiane; Fernandez Del Rio, Lucia; Shu, Cynthia; Baghdasarian, Siyouneh; Zanette, Vanessa; Gerle, Christoph; Jiko, Chimari; Khairallah, Ramzi; Khan, Shaharyar; Rincon Fernandez Pacheco, David; Shabane, Byourak; Erion, Karel; Masand, Ruchi; Dugar, Sundeep; Ghenoiu, Cristina; Schreiner, George; Stiles, Linsey; Liesa, Marc; Shirihai, Orian S.

EMBO J ; 42(10): e111699, 2023 05 15.

Artigo em Inglês | MEDLINE | ID: mdl-36912136

5.

Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA.

Ngo, Jennifer; Choi, Dong Wook; Stanley, Illana A; Stiles, Linsey; Molina, Anthony J A; Chen, Pei-Hsuan; Lako, Ana; Sung, Isabelle Chiao Han; Goswami, Rishov; Kim, Min-Young; Miller, Nathanael; Baghdasarian, Siyouneh; Kim-Vasquez, Doyeon; Jones, Anthony E; Roach, Brett; Gutierrez, Vincent; Erion, Karel; Divakaruni, Ajit S; Liesa, Marc; Danial, Nika N; Shirihai, Orian S.

EMBO J ; 42(11): e111901, 2023 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-36917141

6.

Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer.

Hu, Jian; Hwang, Soyoon Sarah; Liesa, Marc; Gan, Boyi; Sahin, Ergun; Jaskelioff, Mariela; Ding, Zhihu; Ying, Haoqiang; Boutin, Adam T; Zhang, Hailei; Johnson, Shawn; Ivanova, Elena; Kost-Alimova, Maria; Protopopov, Alexei; Wang, Yaoqi Alan; Shirihai, Orian S; Chin, Lynda; DePinho, Ronald A.

Cell ; 148(4): 651-63, 2012 Feb 17.

Artigo em Inglês | MEDLINE | ID: mdl-22341440

7.

The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis.

Acevedo, Aracely; Jones, Anthony E; Danna, Bezawit T; Turner, Rory; Montales, Katrina P; Benincá, Cristiane; Reue, Karen; Shirihai, Orian S; Stiles, Linsey; Wallace, Martina; Wang, Yibin; Bertholet, Ambre M; Divakaruni, Ajit S.

J Biol Chem ; 300(3): 105702, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38301896

8.

Calculation of ATP production rates using the Seahorse XF Analyzer.

Desousa, Brandon R; Kim, Kristen Ko; Jones, Anthony E; Ball, Andréa B; Hsieh, Wei Y; Swain, Pamela; Morrow, Danielle H; Brownstein, Alexandra J; Ferrick, David A; Shirihai, Orian S; Neilson, Andrew; Nathanson, David A; Rogers, George W; Dranka, Brian P; Murphy, Anne N; Affourtit, Charles; Bensinger, Steven J; Stiles, Linsey; Romero, Natalia; Divakaruni, Ajit S.

EMBO Rep ; 24(10): e56380, 2023 10 09.

Artigo em Inglês | MEDLINE | ID: mdl-37548091

9.

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.

Zhong, Lei; D'Urso, Agustina; Toiber, Debra; Sebastian, Carlos; Henry, Ryan E; Vadysirisack, Douangsone D; Guimaraes, Alexander; Marinelli, Brett; Wikstrom, Jakob D; Nir, Tomer; Clish, Clary B; Vaitheesvaran, Bhavapriya; Iliopoulos, Othon; Kurland, Irwin; Dor, Yuval; Weissleder, Ralph; Shirihai, Orian S; Ellisen, Leif W; Espinosa, Joaquin M; Mostoslavsky, Raul.

Cell ; 140(2): 280-93, 2010 Jan 22.

Artigo em Inglês | MEDLINE | ID: mdl-20141841

10.

Author Correction: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.

Kottakis, Filippos; Nicolay, Brandon N; Roumane, Ahlima; Karnik, Rahul; Gu, Hongcang; Nagle, Julia M; Boukhali, Myriam; Hayward, Michele C; Li, Yvonne Y; Chen, Ting; Liesa, Marc; Hammerman, Peter S; Wong, Kwok Kin; Hayes, D Neil; Shirihai, Orian S; Dyson, Nicholas J; Haas, Wilhelm; Meissner, Alexander; Bardeesy, Nabeel.

Nature ; 575(7783): E5, 2019 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-31695192

11.

A novel approach to measure mitochondrial respiration in frozen biological samples.

Acin-Perez, Rebeca; Benador, Ilan Y; Petcherski, Anton; Veliova, Michaela; Benavides, Gloria A; Lagarrigue, Sylviane; Caudal, Arianne; Vergnes, Laurent; Murphy, Anne N; Karamanlidis, Georgios; Tian, Rong; Reue, Karen; Wanagat, Jonathan; Sacks, Harold; Amati, Francesca; Darley-Usmar, Victor M; Liesa, Marc; Divakaruni, Ajit S; Stiles, Linsey; Shirihai, Orian S.

EMBO J ; 39(13): e104073, 2020 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-32432379

12.

Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent.

Wolf, Dane M; Segawa, Mayuko; Kondadi, Arun Kumar; Anand, Ruchika; Bailey, Sean T; Reichert, Andreas S; van der Bliek, Alexander M; Shackelford, David B; Liesa, Marc; Shirihai, Orian S.

EMBO J ; 38(22): e101056, 2019 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-31609012

13.

The biology of lipid droplet-bound mitochondria.

Veliova, Michaela; Petcherski, Anton; Liesa, Marc; Shirihai, Orian S.

Semin Cell Dev Biol ; 108: 55-64, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-32446655

14.

ATP-consuming futile cycles as energy dissipating mechanisms to counteract obesity.

Brownstein, Alexandra J; Veliova, Michaela; Acin-Perez, Rebeca; Liesa, Marc; Shirihai, Orian S.

Rev Endocr Metab Disord ; 23(1): 121-131, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-34741717

15.

Cristae undergo continuous cycles of membrane remodelling in a MICOS-dependent manner.

Kondadi, Arun Kumar; Anand, Ruchika; Hänsch, Sebastian; Urbach, Jennifer; Zobel, Thomas; Wolf, Dane M; Segawa, Mayuko; Liesa, Marc; Shirihai, Orian S; Weidtkamp-Peters, Stefanie; Reichert, Andreas S.

EMBO Rep ; 21(3): e49776, 2020 03 04.

Artigo em Inglês | MEDLINE | ID: mdl-32067344

16.

Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling.

Veliova, Michaela; Ferreira, Caroline M; Benador, Ilan Y; Jones, Anthony E; Mahdaviani, Kiana; Brownstein, Alexandra J; Desousa, Brandon R; Acín-Pérez, Rebeca; Petcherski, Anton; Assali, Essam A; Stiles, Linsey; Divakaruni, Ajit S; Prentki, Marc; Corkey, Barbara E; Liesa, Marc; Oliveira, Marcus F; Shirihai, Orian S.

EMBO Rep ; 21(12): e49634, 2020 12 03.

Artigo em Inglês | MEDLINE | ID: mdl-33275313

17.

LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.

Kottakis, Filippos; Nicolay, Brandon N; Roumane, Ahlima; Karnik, Rahul; Gu, Hongcang; Nagle, Julia M; Boukhali, Myriam; Hayward, Michele C; Li, Yvonne Y; Chen, Ting; Liesa, Marc; Hammerman, Peter S; Wong, Kwok Kin; Hayes, D Neil; Shirihai, Orian S; Dyson, Nicholas J; Haas, Wilhelm; Meissner, Alexander; Bardeesy, Nabeel.

Nature ; 539(7629): 390-395, 2016 11 17.

Artigo em Inglês | MEDLINE | ID: mdl-27799657

18.

Forces, fluxes, and fuels: tracking mitochondrial metabolism by integrating measurements of membrane potential, respiration, and metabolites.

Jones, Anthony E; Sheng, Li; Acevedo, Aracely; Veliova, Michaela; Shirihai, Orian S; Stiles, Linsey; Divakaruni, Ajit S.

Am J Physiol Cell Physiol ; 320(1): C80-C91, 2021 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-33147057

19.

COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10.

Bradley, Michelle C; Yang, Krista; Fernández-Del-Río, Lucía; Ngo, Jennifer; Ayer, Anita; Tsui, Hui S; Novales, Noelle Alexa; Stocker, Roland; Shirihai, Orian S; Barros, Mario H; Clarke, Catherine F.

J Biol Chem ; 295(18): 6023-6042, 2020 05 01.

Artigo em Inglês | MEDLINE | ID: mdl-32205446

20.

MitoTimer-based high-content screen identifies two chemically-related benzothiophene derivatives that enhance basal mitophagy.

Cerqueira, Fernanda M; Kozer, Noga; Petcherski, Anton; Baranovski, Boris M; Wolf, Dane; Assali, Essam A; Roth, Yaelle; Gazit, Roi; Barr, Haim; Lewis, Eli C; Las, Guy; Shirihai, Orian S.

Biochem J ; 477(2): 461-475, 2020 01 31.

Artigo em Inglês | MEDLINE | ID: mdl-32003437

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