Detalhe da pesquisa
1.
The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist.
Acta Crystallogr D Biol Crystallogr
; 65(Pt 5): 449-61, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19390150
2.
Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases.
J Med Chem
; 50(10): 2301-9, 2007 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-17441703
3.
Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138.
FEBS J
; 273(16): 3850-60, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16911530
4.
Structure-activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitor.
J Med Chem
; 49(2): 727-39, 2006 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-16420058
5.
Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes.
J Med Chem
; 47(13): 3381-7, 2004 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-15189034
6.
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.
J Med Chem
; 47(24): 5923-36, 2004 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-15537347
7.
Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1.
J Med Chem
; 47(5): 1175-82, 2004 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-14971897
8.
Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.
J Med Chem
; 51(16): 5000-8, 2008 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18665583
9.
Anti-human immunodeficiency virus type 1 activity of the nonnucleoside reverse transcriptase inhibitor GW678248 in combination with other antiretrovirals against clinical isolate viruses and in vitro selection for resistance.
Antimicrob Agents Chemother
; 49(11): 4465-73, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16251284
10.
Antiviral activity of GW678248, a novel benzophenone nonnucleoside reverse transcriptase inhibitor.
Antimicrob Agents Chemother
; 49(10): 4046-51, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16189079
11.
Fourier transform ion cyclotron resonance MS reveals the presence of a water molecule in an enzyme transition-state analogue complex.
Proc Natl Acad Sci U S A
; 101(43): 15341-5, 2004 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-15494437