Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Silicon switches of marketed drugs.

Pooni, P K; Showell, G A.

Mini Rev Med Chem ; 6(10): 1169-77, 2006 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-17073717

2.

Design strategies for building drug-like chemical libraries.

Mitchell, T; Showell, G A.

Curr Opin Drug Discov Devel ; 4(3): 314-8, 2001 May.

Artigo em Inglês | MEDLINE | ID: mdl-11560064

3.

2-Methyl-1,3-dioxaazaspiro[4.5]decanes as novel muscarinic cholinergic agonists.

Saunders, J; Showell, G A; Snow, R J; Baker, R; Harley, E A; Freedman, S B.

J Med Chem ; 31(2): 486-91, 1988 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-3339620

4.

Synthesis and antihypertensive activity of 6,7-disubstituted trans-4-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ols.

Evans, J M; Fake, C S; Hamilton, T C; Poyser, R H; Showell, G A.

J Med Chem ; 27(9): 1127-31, 1984 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-6471067

5.

Tetrahydropyridyloxadiazoles: semirigid muscarinic ligands.

Showell, G A; Gibbons, T L; Kneen, C O; MacLeod, A M; Merchant, K; Saunders, J; Freedman, S B; Patel, S; Baker, R.

J Med Chem ; 34(3): 1086-94, 1991 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-2002451

6.

Synthesis and characterization of all four isomers of the muscarinic agonist 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane].

Saunders, J; Showell, G A; Baker, R; Freedman, S B; Hill, D; McKnight, A; Newberry, N; Salamone, J D; Hirshfield, J; Springer, J P.

J Med Chem ; 30(6): 969-75, 1987 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-3585909

7.

Thyroid hormone analogues. Synthesis of 3'-substituted 3,5-diiodo-L-thyronines and quantitative structure-activity studies of in vitro and in vivo thyromimetic activities in rat liver and heart.

Leeson, P D; Ellis, D; Emmett, J C; Shah, V P; Showell, G A; Underwood, A H.

J Med Chem ; 31(1): 37-54, 1988 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-3336030

8.

Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane.

Showell, G A; Baker, R; Davis, J; Hargreaves, R; Freedman, S B; Hoogsteen, K; Patel, S; Snow, R J.

J Med Chem ; 35(5): 911-6, 1992 Mar 06.

Artigo em Inglês | MEDLINE | ID: mdl-1548680

9.

Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.

Street, L J; Baker, R; Book, T; Kneen, C O; MacLeod, A M; Merchant, K J; Showell, G A; Saunders, J; Herbert, R H; Freedman, S B.

J Med Chem ; 33(10): 2690-7, 1990 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-2213823

10.

Selective thyromimetics. Cardiac-sparing thyroid hormone analogues containing 3'-arylmethyl substituents.

Leeson, P D; Emmett, J C; Shah, V P; Showell, G A; Novelli, R; Prain, H D; Benson, M G; Ellis, D; Pearce, N J; Underwood, A H.

J Med Chem ; 32(2): 320-36, 1989 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-2913295

11.

L-687,306: a functionally selective and potent muscarinic M1 receptor agonist.

Freedman, S B; Patel, S; Harley, E A; Iversen, L L; Baker, R; Showell, G A; Saunders, J; McKnight, A; Newberry, N; Scholey, K.

Eur J Pharmacol ; 215(1): 135-6, 1992 Apr 29.

Artigo em Inglês | MEDLINE | ID: mdl-1516645

12.

High-affinity and potent, water-soluble 5-amino-1,4-benzodiazepine CCKB/gastrin receptor antagonists containing a cationic solubilizing group.

Showell, G A; Bourrain, S; Neduvelil, J G; Fletcher, S R; Baker, R; Watt, A P; Fletcher, A E; Freedman, S B; Kemp, J A; Marshall, G R.

J Med Chem ; 37(6): 719-21, 1994 Mar 18.

Artigo em Inglês | MEDLINE | ID: mdl-8145219

13.

Binding of 2,4-disubstituted morpholines at human D4 dopamine receptors.

Showell, G A; Emms, F; Marwood, R; O'Connor, D; Patel, S; Leeson, P D.

Bioorg Med Chem ; 6(1): 1-8, 1998 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-9502100

14.

4-Hydroxy-1-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidines: selective h5-HT1D agonists for the treatment of migraine.

Bourrain, S; Neduvelil, J G; Beer, M S; Stanton, J A; Showell, G A; MacLeod, A M.

Bioorg Med Chem Lett ; 9(23): 3369-74, 1999 Dec 06.

Artigo em Inglês | MEDLINE | ID: mdl-10612601

15.

Substituted pyrazoles as novel selective ligands for the human dopamine D4 receptor.

Bourrain, S; Collins, I; Neduvelil, J G; Rowley, M; Leeson, P D; Patel, S; Patel, S; Emms, F; Marwood, R; Chapman, K L; Fletcher, A E; Showell, G A.

Bioorg Med Chem ; 6(10): 1731-43, 1998 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-9839003

16.

Approaches to rational drug development in Alzheimer's disease.

Iversen, L L; Iversen, S D; Freedman, S B; Dawson, G; Rupniak, N; Hargreaves, R J; Showell, G A; Street, L J; Baker, R.

Drug Des Discov ; 9(3-4): 251-9, 1993.

Artigo em Inglês | MEDLINE | ID: mdl-8400006

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