Detalhe da pesquisa
1.
Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1.
Immunity
; 54(9): 1948-1960.e5, 2021 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34343497
2.
Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response.
Proc Natl Acad Sci U S A
; 121(14): e2320013121, 2024 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38547060
3.
GDF15 is a dynamic biomarker of the integrated stress response in the central nervous system.
CNS Neurosci Ther
; 30(2): e14600, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38357857
4.
Sugar phosphate activation of the stress sensor eIF2B.
Nat Commun
; 12(1): 3440, 2021 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34103529
5.
eIF2B activator prevents neurological defects caused by a chronic integrated stress response.
Elife
; 82019 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30624206
6.
The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.
Elife
; 72018 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29489452
7.
Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine.
Elife
; 52016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26928234
8.
Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response.
ChemMedChem
; 11(8): 870-80, 2016 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26789650
9.
Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α.
Elife
; 52016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26928076
10.
The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly.
Elife
; 42015 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25719440
11.
Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic.
Elife
; 42015 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25986605
12.
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.
Elife
; 4: e07314, 2015 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25875391
13.
Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α.
Nat Neurosci
; 17(8): 1073-82, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24974795
14.
Pharmacological brake-release of mRNA translation enhances cognitive memory.
Elife
; 2: e00498, 2013 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23741617