Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.

Mitroulis, Ioannis; Ruppova, Klara; Wang, Baomei; Chen, Lan-Sun; Grzybek, Michal; Grinenko, Tatyana; Eugster, Anne; Troullinaki, Maria; Palladini, Alessandra; Kourtzelis, Ioannis; Chatzigeorgiou, Antonios; Schlitzer, Andreas; Beyer, Marc; Joosten, Leo A B; Isermann, Berend; Lesche, Mathias; Petzold, Andreas; Simons, Kai; Henry, Ian; Dahl, Andreas; Schultze, Joachim L; Wielockx, Ben; Zamboni, Nicola; Mirtschink, Peter; Coskun, Ünal; Hajishengallis, George; Netea, Mihai G; Chavakis, Triantafyllos.

Cell ; 172(1-2): 147-161.e12, 2018 01 11.

Artigo em Inglês | MEDLINE | ID: mdl-29328910

2.

Constitutive formation of caveolae in a bacterium.

Walser, Piers J; Ariotti, Nicholas; Howes, Mark; Ferguson, Charles; Webb, Richard; Schwudke, Dominik; Leneva, Natalya; Cho, Kwang-Jin; Cooper, Leanne; Rae, James; Floetenmeyer, Matthias; Oorschot, Viola M J; Skoglund, Ulf; Simons, Kai; Hancock, John F; Parton, Robert G.

Cell ; 150(4): 752-63, 2012 Aug 17.

Artigo em Inglês | MEDLINE | ID: mdl-22901807

3.

Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders.

Fraldi, Alessandro; Annunziata, Fabio; Lombardi, Alessia; Kaiser, Hermann-Josef; Luis Medina, Diego; Spampanato, Carmine; Olind Fedele, Anthony; Polishchuk, Roman; Sorrentino, Nicolina Cristina; Simons, Kai; Ballabio, Andrea.

EMBO J ; 41(23): e112402, 2022 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-36321514

4.

Lipidomic risk scores are independent of polygenic risk scores and can predict incidence of diabetes and cardiovascular disease in a large population cohort.

Lauber, Chris; Gerl, Mathias J; Klose, Christian; Ottosson, Filip; Melander, Olle; Simons, Kai.

PLoS Biol ; 20(3): e3001561, 2022 03.

Artigo em Inglês | MEDLINE | ID: mdl-35239643

5.

Coming to grips with cell surface polarity.

Simons, Kai.

Nat Rev Mol Cell Biol ; 18(5): 278, 2017 05.

Artigo em Inglês | MEDLINE | ID: mdl-28356572

6.

Cholesteryl hemiazelate identified in CVD patients causes in vitro and in vivo inflammation.

Domingues, Neuza; Gaifem, Joana; Matthiesen, Rune; Saraiva, Diana P; Bento, Luís; Marques, André R A; Soares, Maria I L; Sampaio, Julio; Klose, Christian; Surma, Michal A; Almeida, Manuel S; Rodrigues, Gustavo; Gonçalves, Pedro Araújo; Ferreira, Jorge; E Melo, Ryan Gouveia; Pedro, Luís Mendes; Simons, Kai; Pinho E Melo, Teresa M V D; Cabral, M Guadalupe; Jacinto, Antonio; Silvestre, Ricardo; Vaz, Winchil; Vieira, Otília V.

J Lipid Res ; 64(9): 100419, 2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37482218

7.

Machine learning of human plasma lipidomes for obesity estimation in a large population cohort.

Gerl, Mathias J; Klose, Christian; Surma, Michal A; Fernandez, Celine; Melander, Olle; Männistö, Satu; Borodulin, Katja; Havulinna, Aki S; Salomaa, Veikko; Ikonen, Elina; Cannistraci, Carlo V; Simons, Kai.

PLoS Biol ; 17(10): e3000443, 2019 10.

Artigo em Inglês | MEDLINE | ID: mdl-31626640

8.

Lipidomics: coming to grips with lipid diversity.

Shevchenko, Andrej; Simons, Kai.

Nat Rev Mol Cell Biol ; 11(8): 593-8, 2010 08.

Artigo em Inglês | MEDLINE | ID: mdl-20606693

9.

Revitalizing membrane rafts: new tools and insights.

Simons, Kai; Gerl, Mathias J.

Nat Rev Mol Cell Biol ; 11(10): 688-99, 2010 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-20861879

10.

Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study.

Slieker, Roderick C; Donnelly, Louise A; Fitipaldi, Hugo; Bouland, Gerard A; Giordano, Giuseppe N; Åkerlund, Mikael; Gerl, Mathias J; Ahlqvist, Emma; Ali, Ashfaq; Dragan, Iulian; Festa, Andreas; Hansen, Michael K; Mansour Aly, Dina; Kim, Min; Kuznetsov, Dmitry; Mehl, Florence; Klose, Christian; Simons, Kai; Pavo, Imre; Pullen, Timothy J; Suvitaival, Tommi; Wretlind, Asger; Rossing, Peter; Lyssenko, Valeriya; Legido-Quigley, Cristina; Groop, Leif; Thorens, Bernard; Franks, Paul W; Ibberson, Mark; Rutter, Guy A; Beulens, Joline W J; 't Hart, Leen M; Pearson, Ewan R.

Diabetologia ; 64(9): 1982-1989, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34110439

11.

A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress.

Surma, Michal A; Klose, Christian; Peng, Debby; Shales, Michael; Mrejen, Caroline; Stefanko, Adam; Braberg, Hannes; Gordon, David E; Vorkel, Daniela; Ejsing, Christer S; Farese, Robert; Simons, Kai; Krogan, Nevan J; Ernst, Robert.

Mol Cell ; 51(4): 519-30, 2013 Aug 22.

Artigo em Inglês | MEDLINE | ID: mdl-23891562

12.

Integrative analysis of prognostic biomarkers derived from multiomics panels helps discrimination of chronic kidney disease trajectories in people with type 2 diabetes.

Kammer, Michael; Heinzel, Andreas; Willency, Jill A; Duffin, Kevin L; Mayer, Gert; Simons, Kai; Gerl, Mathias J; Klose, Christian; Heinze, Georg; Reindl-Schwaighofer, Roman; Hu, Karin; Perco, Paul; Eder, Susanne; Rosivall, Laszlo; Mark, Patrick B; Ju, Wenjun; Kretzler, Matthias; McCarthy, Mark I; Heerspink, Hiddo L; Wiecek, Andrzej; Gomez, Maria F; Oberbauer, Rainer.

Kidney Int ; 96(6): 1381-1388, 2019 12.

Artigo em Inglês | MEDLINE | ID: mdl-31679767

13.

How Can Omic Science be Improved?

Simons, Kai.

Proteomics ; 18(5-6): e1800039, 2018 03.

Artigo em Inglês | MEDLINE | ID: mdl-29417741

14.

N-Glycosylation as determinant of epidermal growth factor receptor conformation in membranes.

Kaszuba, Karol; Grzybek, Michal; Orlowski, Adam; Danne, Reinis; Róg, Tomasz; Simons, Kai; Coskun, Ünal; Vattulainen, Ilpo.

Proc Natl Acad Sci U S A ; 112(14): 4334-9, 2015 Apr 07.

Artigo em Inglês | MEDLINE | ID: mdl-25805821

15.

Hopanoids as functional analogues of cholesterol in bacterial membranes.

Sáenz, James P; Grosser, Daniel; Bradley, Alexander S; Lagny, Thibaut J; Lavrynenko, Oksana; Broda, Martyna; Simons, Kai.

Proc Natl Acad Sci U S A ; 112(38): 11971-6, 2015 Sep 22.

Artigo em Inglês | MEDLINE | ID: mdl-26351677

16.

Cell membranes: A subjective perspective.

Simons, Kai.

Biochim Biophys Acta ; 1858(10): 2569-2572, 2016 10.

Artigo em Inglês | MEDLINE | ID: mdl-26827711

17.

Glycosylphosphatidylinositol-anchored proteins: Membrane organization and transport.

Zurzolo, Chiara; Simons, Kai.

Biochim Biophys Acta ; 1858(4): 632-9, 2016 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-26706096

18.

Membrane raft association is a determinant of plasma membrane localization.

Diaz-Rohrer, Blanca B; Levental, Kandice R; Simons, Kai; Levental, Ilya.

Proc Natl Acad Sci U S A ; 111(23): 8500-5, 2014 Jun 10.

Artigo em Inglês | MEDLINE | ID: mdl-24912166

19.

Orm family proteins mediate sphingolipid homeostasis.

Breslow, David K; Collins, Sean R; Bodenmiller, Bernd; Aebersold, Ruedi; Simons, Kai; Shevchenko, Andrej; Ejsing, Christer S; Weissman, Jonathan S.

Nature ; 463(7284): 1048-53, 2010 Feb 25.

Artigo em Inglês | MEDLINE | ID: mdl-20182505

20.

Functional convergence of hopanoids and sterols in membrane ordering.

Sáenz, James Peter; Sezgin, Erdinc; Schwille, Petra; Simons, Kai.

Proc Natl Acad Sci U S A ; 109(35): 14236-40, 2012 Aug 28.

Artigo em Inglês | MEDLINE | ID: mdl-22893685

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Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.

Constitutive formation of caveolae in a bacterium.

Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders.

Lipidomic risk scores are independent of polygenic risk scores and can predict incidence of diabetes and cardiovascular disease in a large population cohort.

Coming to grips with cell surface polarity.

Cholesteryl hemiazelate identified in CVD patients causes in vitro and in vivo inflammation.

Machine learning of human plasma lipidomes for obesity estimation in a large population cohort.

Lipidomics: coming to grips with lipid diversity.

Revitalizing membrane rafts: new tools and insights.

Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study.

A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress.

Integrative analysis of prognostic biomarkers derived from multiomics panels helps discrimination of chronic kidney disease trajectories in people with type 2 diabetes.

How Can Omic Science be Improved?

N-Glycosylation as determinant of epidermal growth factor receptor conformation in membranes.

Hopanoids as functional analogues of cholesterol in bacterial membranes.

Cell membranes: A subjective perspective.

Glycosylphosphatidylinositol-anchored proteins: Membrane organization and transport.

Membrane raft association is a determinant of plasma membrane localization.

Orm family proteins mediate sphingolipid homeostasis.

Functional convergence of hopanoids and sterols in membrane ordering.