Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis.

Rashidieh, Behnam; Shohayeb, Belal; Bain, Amanda Louise; Fortuna, Patrick R J; Sinha, Debottam; Burgess, Andrew; Mills, Richard; Adams, Rachael C; Lopez, J Alejandro; Blumbergs, Peter; Finnie, John; Kalimutho, Murugan; Piper, Michael; Hudson, James Edward; Ng, Dominic C H; Khanna, Kum Kum.

PLoS Genet ; 17(10): e1009334, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-34710087

2.

Pretransplant Cytomegalovirus-Specific Cellular Immunity and Risk of Viral Reactivation Following Lung Transplantation: A Prospective Cohort Study.

Altaf, Mohammed; Lineburg, Katie E; Crooks, Pauline; Rehan, Sweera; Matthews, Katherine K; Neller, Michelle A; Ambalathingal, George R; Sinha, Debottam; Grant, Michelle; Hopkins, Peter M A; Chambers, Daniel; Khanna, Rajiv; Smith, Corey.

J Infect Dis ; 224(2): 312-317, 2021 07 15.

Artigo em Inglês | MEDLINE | ID: mdl-33274385

3.

Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti-PD-L1 antibody for treatment of triple-negative breast cancer.

Raninga, Prahlad V; Lee, Andy C; Sinha, Debottam; Shih, Yu-Yin; Mittal, Deepak; Makhale, Ashwini; Bain, Amanda L; Nanayakarra, Devathri; Tonissen, Kathryn F; Kalimutho, Murugan; Khanna, Kum Kum.

Int J Cancer ; 146(1): 123-136, 2020 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-31090219

4.

Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling.

Sinha, Debottam; Kalimutho, Murugan; Bowles, Josephine; Chan, Ai-Leen; Merriner, D Jo; Bain, Amanda L; Simmons, Jacinta L; Freire, Raimundo; Lopez, J Alejandro; Hobbs, Robin M; O'Bryan, Moira K; Khanna, Kum Kum.

FASEB J ; 32(9): 4984-4999, 2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-29683733

5.

EBV and myeloid-derived suppressor cells.

Sinha, Debottam; Khanna, Rajiv.

Blood ; 137(2): 148-150, 2021 01 14.

Artigo em Inglês | MEDLINE | ID: mdl-33443554

6.

Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicity.

Wright, Quentin G; Sinha, Debottam; Wells, James W; Frazer, Ian H; Gonzalez Cruz, Jazmina L; Leggatt, Graham Robert.

J Immunother Cancer ; 12(1)2024 01 31.

Artigo em Inglês | MEDLINE | ID: mdl-38296598

7.

Characterization of the skin microbiome in normal and cutaneous squamous cell carcinoma affected cats and dogs.

Bromfield, Jacoba I; Zaugg, Julian; Straw, Rodney C; Cathie, Julia; Krueger, Annika; Sinha, Debottam; Chandra, Janin; Hugenholtz, Philip; Frazer, Ian H.

mSphere ; 9(4): e0055523, 2024 Apr 23.

Artigo em Inglês | MEDLINE | ID: mdl-38530017

8.

Molecular mechanisms augmenting resistance to current therapies in clinics among cervical cancer patients.

Das, Soumik; Babu, Achsha; Medha, Tamma; Ramanathan, Gnanasambandan; Mukherjee, Anirban Goutam; Wanjari, Uddesh Ramesh; Murali, Reshma; Kannampuzha, Sandra; Gopalakrishnan, Abilash Valsala; Renu, Kaviyarasi; Sinha, Debottam; George Priya Doss, C.

Med Oncol ; 40(5): 149, 2023 Apr 15.

Artigo em Inglês | MEDLINE | ID: mdl-37060468

9.

Repurposing of Commercially Existing Molecular Target Therapies to Boost the Clinical Efficacy of Immune Checkpoint Blockade.

Sinha, Debottam; Moseley, Philip; Lu, Xuehan; Wright, Quentin; Gabrielli, Brian; Frazer, Ian H; Cruz, Jazmina L G.

Cancers (Basel) ; 14(24)2022 Dec 13.

Artigo em Inglês | MEDLINE | ID: mdl-36551637

10.

Joining Forces: Improving Clinical Response to Cellular Immunotherapies with Small-Molecule Inhibitors.

Sinha, Debottam; Smith, Corey; Khanna, Rajiv.

Trends Mol Med ; 27(1): 75-90, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-33011081

11.

'Off-the-shelf' allogeneic antigen-specific adoptive T-cell therapy for the treatment of multiple EBV-associated malignancies.

Sinha, Debottam; Srihari, Sriganesh; Beckett, Kirrliee; Le Texier, Laetitia; Solomon, Matthew; Panikkar, Archana; Ambalathingal, George R; Lekieffre, Lea; Crooks, Pauline; Rehan, Sweera; Neller, Michelle A; Smith, Corey; Khanna, Rajiv.

J Immunother Cancer ; 9(2)2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33589524

12.

Cep55 overexpression promotes genomic instability and tumorigenesis in mice.

Sinha, Debottam; Nag, Purba; Nanayakkara, Devathri; Duijf, Pascal H G; Burgess, Andrew; Raninga, Prahlad; Smits, Veronique A J; Bain, Amanda L; Subramanian, Goutham; Wall, Meaghan; Finnie, John W; Kalimutho, Murugan; Khanna, Kum Kum.

Commun Biol ; 3(1): 593, 2020 10 21.

Artigo em Inglês | MEDLINE | ID: mdl-33087841

13.

Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition.

Raninga, Prahlad V; Lee, Andy; Sinha, Debottam; Dong, Lan-Feng; Datta, Keshava K; Lu, Xue; Kalita-de Croft, Priyakshi; Dutt, Mriga; Hill, Michelle; Pouliot, Normand; Gowda, Harsha; Kalimutho, Murugan; Neuzil, Jiri; Khanna, Kum Kum.

Theranostics ; 10(12): 5259-5275, 2020.

Artigo em Inglês | MEDLINE | ID: mdl-32373211

14.

Mitotic slippage: an old tale with a new twist.

Sinha, Debottam; Duijf, Pascal H G; Khanna, Kum Kum.

Cell Cycle ; 18(1): 7-15, 2019 01.

Artigo em Inglês | MEDLINE | ID: mdl-30601084

15.

Prophylactic and therapeutic strategies for Epstein-Barr virus-associated diseases: emerging strategies for clinical development.

Dasari, Vijayendra; Sinha, Debottam; Neller, Michelle A; Smith, Corey; Khanna, Rajiv.

Expert Rev Vaccines ; 18(5): 457-474, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30987475

16.

Blockade of PDGFRß circumvents resistance to MEK-JAK inhibition via intratumoral CD8⁺ T-cells infiltration in triple-negative breast cancer.

Kalimutho, Murugan; Sinha, Debottam; Mittal, Deepak; Srihari, Sriganesh; Nanayakkara, Devathri; Shafique, Shagufta; Raninga, Prahlad; Nag, Purba; Parsons, Kate; Khanna, Kum Kum.

J Exp Clin Cancer Res ; 38(1): 85, 2019 Feb 18.

Artigo em Inglês | MEDLINE | ID: mdl-30777101

17.

CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer.

Kalimutho, Murugan; Sinha, Debottam; Jeffery, Jessie; Nones, Katia; Srihari, Sriganesh; Fernando, Winnie C; Duijf, Pascal Hg; Vennin, Claire; Raninga, Prahlad; Nanayakkara, Devathri; Mittal, Deepak; Saunus, Jodi M; Lakhani, Sunil R; López, J Alejandro; Spring, Kevin J; Timpson, Paul; Gabrielli, Brian; Waddell, Nicola; Khanna, Kum Kum.

EMBO Mol Med ; 10(9)2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-30108112

18.

Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae.

Kalimutho, Murugan; Bain, Amanda L; Mukherjee, Bipasha; Nag, Purba; Nanayakkara, Devathri M; Harten, Sarah K; Harris, Janelle L; Subramanian, Goutham N; Sinha, Debottam; Shirasawa, Senji; Srihari, Sriganesh; Burma, Sandeep; Khanna, Kum Kum.

Mol Oncol ; 11(5): 470-490, 2017 05.

Artigo em Inglês | MEDLINE | ID: mdl-28173629

19.

Adenosine 2B Receptor Expression on Cancer Cells Promotes Metastasis.

Mittal, Deepak; Sinha, Debottam; Barkauskas, Deborah; Young, Arabella; Kalimutho, Murugan; Stannard, Kimberley; Caramia, Franco; Haibe-Kains, Benjamin; Stagg, John; Khanna, Kum Kum; Loi, Sherene; Smyth, Mark J.

Cancer Res ; 76(15): 4372-82, 2016 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-27221704

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