Detalhe da pesquisa
1.
A PEGylated analog of the gut hormone oxyntomodulin with long-lasting antihyperglycemic, insulinotropic and anorexigenic activity.
Bioorg Med Chem
; 21(22): 7064-73, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24094437
2.
Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine.
Bioorg Med Chem Lett
; 22(4): 1774-8, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22248857
3.
Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors.
Bioorg Med Chem Lett
; 22(4): 1550-6, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22264488
4.
Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors.
Bioorg Med Chem Lett
; 22(4): 1727-30, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22290078
5.
Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors.
Bioorg Med Chem Lett
; 21(5): 1299-305, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21315588
6.
DPP-IV-resistant, long-acting oxyntomodulin derivatives.
J Pept Sci
; 17(4): 270-80, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21294225
7.
Expression, purification and crystallization of human prolylcarboxypeptidase.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 66(Pt 6): 702-5, 2010 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20516604
8.
A Long-Acting PYY3-36 Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates.
Cell Metab
; 29(4): 837-843.e5, 2019 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30773465
9.
A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice.
Endocrinol Diabetes Metab
; 1(1): e00002, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-30815539
10.
The glucagon receptor is involved in mediating the body weight-lowering effects of oxyntomodulin.
Obesity (Silver Spring)
; 20(8): 1566-71, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22421924
11.
Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents.
Biopolymers
; 98(5): 443-50, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23203689
12.
Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice.
Diabetes
; 58(10): 2258-66, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19602537