RESUMO
Background: Impulsivity is implicated in the development and maintenance of Cocaine Use Disorder (CUD). Less work has examined impulsivity's role on interest in initiating treatment, treatment adherence, or treatment response. No pharmacotherapies are approved for CUD, so efforts to understand and bolster the effects of psychotherapy are important in guiding and refining treatment. The present study examined the impact of impulsivity on interest in treatment, treatment initiation, treatment adherence, and treatment outcomes in individuals with CUD. Methods: Following the completion of a larger study on impulsivity and CUD participants were offered 14 sessions of (12 weeks) Cognitive Behavioral Relapse Prevention (CBT-RP). Before starting treatment, participants completed seven self-report and four behavioral measures of impulsivity. Sixty-eight healthy adults (36% female) with CUD (aged 49.4 ± 7.9) expressed an interest in treatment. Results: Greater scores on several self-report measures of impulsivity, and fewer difficulties with delayed gratification were associated with increased interest in treatment in both males and females. 55 participants attended at least 1 treatment session, while 13 participants did attend a single session. Individuals who attended at least one treatment session scored lower on measures of lack of perseverance and procrastination. Still, measures of impulsivity did not reliably predict session attendance nor the frequency of cocaine-positive urine samples throughout treatment. Males attended nearly twice as many treatment sessions as females despite nonsignificant associations between impulsivity in males and the number of sessions attended. Conclusions: Greater impulsivity in individuals with CUD was associated with expressing an interest in treatment, but not treatment adherence or response.
Assuntos
Transtornos Relacionados ao Uso de Cocaína , Cocaína , Transtornos Relacionados ao Uso de Substâncias , Adulto , Masculino , Humanos , Feminino , Transtornos Relacionados ao Uso de Cocaína/psicologia , Resultado do Tratamento , Cocaína/uso terapêutico , Comportamento ImpulsivoAssuntos
Bromocriptina/farmacologia , Hipófise/metabolismo , Transcrição Gênica/efeitos dos fármacos , Animais , Eletroforese em Gel de Poliacrilamida , Feminino , Técnicas In Vitro , Leucina/metabolismo , Hipófise/efeitos dos fármacos , Poli A/metabolismo , Prolactina/biossíntese , Prolactina/metabolismo , RNA/biossíntese , RNA Mensageiro/metabolismo , RatosRESUMO
A patient is presented who developed acute life-threatening diarrhoea due to infestation with Giardia lamblia. We propose that the severity of the illness may have been related to hypochlorhydria following gastric surgery.
Assuntos
Acloridria/complicações , Giardíase/etiologia , Enteropatias Parasitárias/etiologia , Síndromes Pós-Gastrectomia/complicações , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
This report deals with a 25-year-old man with chronic active hepatitis and cirrhosis who developed the rare complication of pyoderma gangrenosum which improved rapidly following the commencement of prednisolone.