Detalhe da pesquisa
1.
Synthesis and evaluation of highly potent HBV capsid assembly modulators (CAMs).
Bioorg Chem
; 141: 106923, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37871391
2.
Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models.
Int J Mol Sci
; 24(22)2023 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38003463
3.
Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate.
PLoS Pathog
; 11(6): e1004995, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26098424
4.
Intramolecular Hydrogen-Bonding Effects on the Fluorescence of PRODAN Derivatives.
J Phys Chem A
; 120(20): 3518-23, 2016 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27127907
5.
The anaerobic co-digestion of fruit and vegetable waste and horse manure mixtures in a bench-scale, two-phase anaerobic digestion system.
Environ Technol
; 35(5-8): 859-67, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24645468
6.
An in vivo duck hepatitis B virus model recapitulates key aspects of nucleic acid polymer treatment outcomes in chronic hepatitis B patients.
Antiviral Res
; 224: 105835, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38401714
7.
Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir.
Antimicrob Agents Chemother
; 56(2): 830-7, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22143520
8.
Discovery of 4'-azido-2'-deoxy-2'-C-methyl cytidine and prodrugs thereof: a potent inhibitor of Hepatitis C virus replication.
Bioorg Med Chem Lett
; 22(9): 3265-8, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22472694
9.
Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules.
Mol Ther Nucleic Acids
; 27: 335-348, 2022 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35024245
10.
Learning and generalization of within-category representations in a rule-based category structure.
Atten Percept Psychophys
; 82(5): 2448-2462, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-32333374
11.
A modern reassessment of glycoprotein-specific direct platelet autoantibody testing in immune thrombocytopenia.
Blood Adv
; 4(1): 9-18, 2020 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31891657
12.
Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C.
J Med Chem
; 63(18): 10380-10395, 2020 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32816483
13.
Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer.
N Engl J Med
; 355(1): 11-20, 2006 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16822992
14.
The application of the phosphoramidate ProTide approach confers micromolar potency against hepatitis C virus on inactive agent 4'-azidoinosine: kinase bypass on a dual base/sugar modified nucleoside.
Bioorg Med Chem Lett
; 19(11): 3122-4, 2009 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19398331
15.
The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4'-azidocytidine (R1479).
Bioorg Med Chem Lett
; 19(15): 4250-4, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19505826
16.
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides.
Bioorg Med Chem Lett
; 19(19): 5652-6, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19709881
17.
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones.
Bioorg Med Chem Lett
; 19(13): 3642-6, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19457662
18.
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids.
Bioorg Med Chem Lett
; 19(19): 5648-51, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19700319
19.
Synthesis and Anti-HCV Activities of 4'-Fluoro-2'-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4'-Fluoro-2'- C-methyluridine 5'-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection.
J Med Chem
; 62(9): 4555-4570, 2019 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30951311
20.
Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): a randomised controlled trial.
Lancet
; 370(9582): 143-152, 2007 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17630037