Detalhe da pesquisa
1.
Emergence of resistance to tyrosine kinase inhibitors in non-small-cell lung cancer can be delayed by an upfront combination with the HSP90 inhibitor onalespib.
Br J Cancer
; 115(9): 1069-1077, 2016 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27673365
2.
Epigenetic Priming by Hypomethylation Enhances the Immunogenic Potential of Tolinapant in T-cell Lymphoma.
Cancer Res Commun
; 4(6): 1441-1453, 2024 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38727208
3.
Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2).
J Med Chem
; 67(6): 4655-4675, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38462716
4.
A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation.
Mol Cancer
; 12(1): 128, 2013 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24156782
5.
The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non-small cell lung cancer.
Cancer Sci
; 103(3): 522-7, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22181674
6.
Activity of the multitargeted kinase inhibitor, AT9283, in imatinib-resistant BCR-ABL-positive leukemic cells.
Blood
; 116(12): 2089-95, 2010 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20548094
7.
Antagonism of inhibitors of apoptosis proteins reveals a novel, immune response-based therapeutic approach for T-cell lymphoma.
Blood Adv
; 5(20): 4003-4016, 2021 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34474469
8.
Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer.
Mol Cancer Ther
; 20(9): 1627-1639, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34389694
9.
Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance.
Nat Commun
; 12(1): 3364, 2021 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34099649
10.
AT9283, a potent inhibitor of the Aurora kinases and Jak2, has therapeutic potential in myeloproliferative disorders.
Br J Haematol
; 150(1): 46-57, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20507304
11.
Elucidation of the MD-2/TLR4 interface required for signaling by lipid IVa.
J Immunol
; 181(2): 1245-54, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18606678
12.
Phase 1 study of the HSP90 inhibitor onalespib in combination with AT7519, a pan-CDK inhibitor, in patients with advanced solid tumors.
Cancer Chemother Pharmacol
; 86(6): 815-827, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33095286
13.
Dexamethasone modulates Salmonella enterica serovar Typhimurium infection in vivo independently of the glucocorticoid-inducible protein annexin-A1.
FEMS Immunol Med Microbiol
; 54(3): 339-48, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19049646
14.
ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth.
Mol Cancer Ther
; 17(7): 1381-1391, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29695633
15.
A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660).
J Med Chem
; 61(16): 7314-7329, 2018 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30091600
16.
Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells.
Cancer Res
; 76(9): 2731-42, 2016 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27197266
17.
Inhibition of HSP90 by AT13387 delays the emergence of resistance to BRAF inhibitors and overcomes resistance to dual BRAF and MEK inhibition in melanoma models.
Mol Cancer Ther
; 13(12): 2793-2804, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25349308
18.
The HSP90 inhibitor, AT13387, is effective against imatinib-sensitive and -resistant gastrointestinal stromal tumor models.
Mol Cancer Ther
; 11(8): 1799-808, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22714264
19.
Differential modulatory effects of annexin 1 on nitric oxide synthase induction by lipopolysaccharide in macrophages.
Immunology
; 117(3): 340-9, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16476053