Contrast-enhanced ultrasound (CEUS) for the evaluation of focal liver lesions - a prospective multicenter study of its usefulness in clinical practice.

PURPOSE: To assess the value of contrast-enhanced ultrasound (CEUS) for differentiating malignant from benign focal liver lesions (FLLs) and for diagnosing different FLL types. MATERIAL AND METHODS: CEUS performed in 14 Romanian centers was prospectively collected between February 2011 and June 2012. The inclusion criteria were: age > 18 years; patients diagnosed with 1 - 3 de novo FLLs on B-mode ultrasound; reference method (computed tomography (CT), magnetic resonance imaging (MRI) or biopsy) available; patient's informed consent. FLL lesions were characterized during CEUS according to the European Federation of Societies for Ultrasound in Medicine and Biology guidelines. For statistical analysis, indeterminate FLLs at CEUS were rated as false classifications. RESULTS: A total number of 536 cases were included in the final analysis, 344 malignant lesions (64.2 %) and 192 benign lesions (35.8 %). The reference method was: CT/MRI - 379 cases (70.7 %), pathological exam - 150 cases (27.9 %) and aspiration of liver abscesses - 7 cases (1.4 %). CEUS was conclusive in 89.3 % and inconclusive in 10.7 % of cases. To differentiate between malignant and benign FLLs, CEUS had 85.7 % sensitivity, 85.9 % specificity, 91.6 % positive predictive value, 77.1 % negative predictive value and 85.8 % accuracy. The CEUS accuracy for differentiation between malignant and benign liver lesions was similar in tumors with diameter ≤ 2 cm and those with diameter > 2 cm. CONCLUSION: CEUS represents a useful method in clinical practice for differentiating between malignant and benign FLLs detected on standard ultrasonography, and the results of this study are in concordance with previous multicenter studies: DEGUM (Germany) and STIC (France).

The combined role of intravenous contrast enhanced ultrasound (CEUS) and computed tomography (CT) in liver abscess diagnosis.

BACKGROUND AND AIMS: Through this study, we intend to review the main aspects regarding the contrast enhanced ultrasound evaluation of liver abscesses, pursuing a comparative analysis between the medical literature and our own experience. MATERIAL AND METHODS: From June 2008 until December 2010 we have evaluated in our department a consecutive series of 11 patients with liver abscesses (7 males, 63.63%) all between the ages of 45 and 74. All the patients displayed a clinical and biological picture leading to an inflammatory process. The imaging diagnosis was made after confronting the results of the contrast enhanced ultrasound with those of the computed tomography. RESULTS: In 10 out of 11 patients that were part of the study, we have assessed 14 liver abscesses. A single patient showed spread lesions inside both liver lobes, and they were assessed as hepatic micro abscesses. Three of the patients showed multiple right lobe lesions, 7 patients showed single lesions and one patient showed disseminated lesions within both lobes. We examined six mature lesions, 4 lesions with incomplete necrosis and 4 immature lesions, with no necrosis. The particular aspect of mycotic microabscesses is mentioned at the conventional ultrasound and at the CEUS as well. CONCLUSION: Various types of hepatic abscesses have different imaging findings, and typical CT and CEUS findings can suggest the diagnosis.

Experimental Model of Mixed Intestinal Infarction in Rabbit.

The article presents an experimental model of the mixed intestinal infarction obtained by ligaturing of the cranial mesenteric artery (CMA) and of the cranial mesenteric vein (CMV) in rabbit.