Detalhe da pesquisa
1.
Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease.
Bioorg Med Chem Lett
; 28(21): 3458-3462, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30249354
2.
CSAR 2014: A Benchmark Exercise Using Unpublished Data from Pharma.
J Chem Inf Model
; 56(6): 1063-77, 2016 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27149958
3.
Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Bioorg Med Chem Lett
; 21(20): 6188-94, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21903390
4.
Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode.
Bioorg Med Chem Lett
; 18(1): 318-23, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18006306
5.
Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening.
J Med Chem
; 59(6): 2452-67, 2016 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26938474
6.
Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors.
ACS Med Chem Lett
; 7(4): 379-84, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27096045
7.
Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
J Med Chem
; 59(11): 5356-67, 2016 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27167608
8.
The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits.
J Med Chem
; 58(18): 7140-63, 2015 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26090771
9.
Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 urea leads to potent intracellular inhibitors of hepatitis C virus NS3/4A protease.
Org Lett
; 5(24): 4627-30, 2003 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-14627400
10.
Pyrrolidine-5,5-trans-lactams. 2. The use of X-ray crystal structure data in the optimization of P3 and P4 substituents.
Org Lett
; 4(25): 4479-82, 2002 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-12465917
11.
Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy.
ACS Med Chem Lett
; 4(10): 948-52, 2013 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900590
12.
p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression.
J Med Chem
; 52(20): 6257-69, 2009 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19772287
13.
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3.
Bioorg Med Chem Lett
; 17(5): 1296-301, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17194588