Detalhe da pesquisa
1.
Engineering a monomeric Fc domain modality by N-glycosylation for the half-life extension of biotherapeutics.
J Biol Chem
; 288(23): 16529-16537, 2013 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23615911
2.
Atypical antigen recognition mode of a shark immunoglobulin new antigen receptor (IgNAR) variable domain characterized by humanization and structural analysis.
J Biol Chem
; 288(24): 17408-19, 2013 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23632026
3.
Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci
; 17(1): 16-21, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18042673
4.
A novel approach to identifying beta-secretase inhibitors: bis-statine peptide mimetics discovered using structure and spot synthesis.
Peptides
; 27(7): 1877-85, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16574278
5.
Understanding the selectivity of genistein for human estrogen receptor-beta using X-ray crystallography and computational methods.
Structure
; 12(12): 2197-207, 2004 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-15576033
6.
Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme.
Structure
; 11(6): 627-36, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12791252
7.
Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer.
Antibodies (Basel)
; 5(1)2016 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31557987
8.
Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites.
J Mol Biol
; 316(2): 277-89, 2002 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-11851338
9.
Use of structure-based drug design approaches to obtain novel anthranilic acid acyl carrier protein synthase inhibitors.
J Med Chem
; 48(25): 7960-9, 2005 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16335920
10.
Quinic acid derivatives as sialyl Lewis(x)-mimicking selectin inhibitors: design, synthesis, and crystal structure in complex with E-selectin.
J Med Chem
; 48(13): 4346-57, 2005 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15974587
11.
Faster in vivo clearance of human embryonic kidney than Chinese hamster ovary cell derived protein: Role of glycan mediated clearance.
J Biosci Bioeng
; 119(6): 657-60, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25575972
12.
Triad of polar residues implicated in pH specificity of acidic mammalian chitinase.
Protein Sci
; 18(3): 569-78, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19241384
13.
The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition.
J Biol Chem
; 281(47): 36378-90, 2006 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-17005555
14.
Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation.
Science
; 301(5630): 222-6, 2003 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-12855811
15.
Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutations.
J Biol Chem
; 279(22): 23327-34, 2004 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-15039442
16.
Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase.
J Biol Chem
; 277(5): 3698-707, 2002 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-11704676
17.
Catalytic domain crystal structure of protein kinase C-theta (PKCtheta).
J Biol Chem
; 279(48): 50401-9, 2004 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-15364937
18.
Structure-based design of estrogen receptor-beta selective ligands.
J Am Chem Soc
; 126(46): 15106-19, 2004 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15548008