Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Detection of a 7SL RNA-derived small non-coding RNA using Molecular Beacons in vitro and in cells.

Weigert, Nina; Schweiger, Anna-Lena; Gross, Jonas; Matthes, Marie; Corbacioglu, Selim; Sommer, Gunhild; Heise, Tilman.

Biol Chem ; 404(11-12): 1123-1136, 2023 10 26.

Artigo em Inglês | MEDLINE | ID: mdl-37632732

2.

Role of the RNA-binding protein La in cancer pathobiology.

Sommer, Gunhild; Heise, Tilman.

RNA Biol ; 18(2): 218-236, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-32687431

3.

Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells.

Waetzig, Rebecca; Matthes, Marie; Leister, Johannes; Penkivech, Gina; Heise, Tilman; Corbacioglu, Selim; Sommer, Gunhild.

Int J Med Sci ; 18(1): 137-149, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33390782

4.

Novel RNA chaperone domain of RNA-binding protein La is regulated by AKT phosphorylation.

Kuehnert, Julia; Sommer, Gunhild; Zierk, Avery W; Fedarovich, Alena; Brock, Alexander; Fedarovich, Dzmitry; Heise, Tilman.

Nucleic Acids Res ; 43(1): 581-94, 2015 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-25520193

5.

Imatinib resistance and microcytic erythrocytosis in a KitV558Δ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor.

Bosbach, Benedikt; Deshpande, Shayu; Rossi, Ferdinand; Shieh, Jae-Hung; Sommer, Gunhild; de Stanchina, Elisa; Veach, Darren R; Scandura, Joseph M; Manova-Todorova, Katia; Moore, Malcolm A S; Antonescu, Cristina R; Besmer, Peter.

Proc Natl Acad Sci U S A ; 109(34): E2276-83, 2012 Aug 21.

Artigo em Inglês | MEDLINE | ID: mdl-22652566

6.

Evaluating the RIST Molecular-Targeted Regimen in a Three-Dimensional Neuroblastoma Spheroid Cell Culture Model.

Kaess, Carina; Matthes, Marie; Gross, Jonas; Waetzig, Rebecca; Heise, Tilman; Corbacioglu, Selim; Sommer, Gunhild.

Cancers (Basel) ; 15(6)2023 Mar 14.

Artigo em Inglês | MEDLINE | ID: mdl-36980635

7.

Heparanase wildtype is associated with a reduced incidence of transplant-associated systemic vasculopathies.

Mueckenhausen, Raphaela; Föll, Jürgen; Kleinschmidt, Katharina; Tröger, Anja; Malaisé, Muriel; Wolff, Daniel; Holler, Ernst; Matthes, Marie; Heise, Tilman; Sommer, Gunhild; Corbacioglu, Selim.

Hematol Oncol Stem Cell Ther ; 16(3): 217-229, 2023 Apr 04.

Artigo em Inglês | MEDLINE | ID: mdl-34848216

8.

RNA-Binding Protein La Mediates TGFß-Induced Epithelial to Mesenchymal Transition and Cancer Stem Cell Properties.

Heise, Tilman; Sommer, Gunhild.

Cancers (Basel) ; 13(2)2021 Jan 19.

Artigo em Inglês | MEDLINE | ID: mdl-33477794

9.

Critical role for Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development.

Agosti, Valter; Corbacioglu, Selim; Ehlers, Imke; Waskow, Claudia; Sommer, Gunhild; Berrozpe, Georgina; Kissel, Holger; Tucker, Christine M; Manova, Katia; Moore, Malcolm A S; Rodewald, Hans-Reimer; Besmer, Peter.

J Exp Med ; 199(6): 867-78, 2004 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-15024050

10.

Salt-Dependent Modulation of the RNA Chaperone Activity of RNA-Binding Protein La.

Sommer, Gunhild; Sendlmeier, Christina; Heise, Tilman.

Methods Mol Biol ; 2106: 121-136, 2020.

Artigo em Inglês | MEDLINE | ID: mdl-31889254

11.

Posttranscriptional control of HBV gene expression.

Sommer, Gunhild; Heise, Tilman.

Front Biosci ; 13: 5533-47, 2008 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-18508603

12.

The hepatitis B virus PRE contains a splicing regulatory element.

Heise, Tilman; Sommer, Gunhild; Reumann, Kerstin; Meyer, Imke; Will, Hans; Schaal, Heiner.

Nucleic Acids Res ; 34(1): 353-63, 2006.

Artigo em Inglês | MEDLINE | ID: mdl-16410615

13.

SUMO Modification of the RNA-Binding Protein La Regulates Cell Proliferation and STAT3 Protein Stability.

Kota, Venkatesh; Sommer, Gunhild; Hazard, E Starr; Hardiman, Gary; Twiss, Jeffery L; Heise, Tilman.

Mol Cell Biol ; 38(2)2018 01 15.

Artigo em Inglês | MEDLINE | ID: mdl-29084811

14.

Applying a high-throughput fluorescence polarization assay for the discovery of chemical probes blocking La:RNA interactions in vitro and in cells.

Sommer, Gunhild; Fedarovich, Alena; Kota, Venkatesh; Rodriguez, Reycel; Smith, Charles D; Heise, Tilman.

PLoS One ; 12(3): e0173246, 2017.

Artigo em Inglês | MEDLINE | ID: mdl-28291789

15.

SUMO-Modification of the La Protein Facilitates Binding to mRNA In Vitro and in Cells.

Kota, Venkatesh; Sommer, Gunhild; Durette, Chantal; Thibault, Pierre; van Niekerk, Erna A; Twiss, Jeffery L; Heise, Tilman.

PLoS One ; 11(5): e0156365, 2016.

Artigo em Inglês | MEDLINE | ID: mdl-27224031

16.

The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2.

Heise, Tilman; Kota, Venkatesh; Brock, Alexander; Morris, Amanda B; Rodriguez, Reycel M; Zierk, Avery W; Howe, Philip H; Sommer, Gunhild.

Oncotarget ; 7(20): 29664-76, 2016 May 17.

Artigo em Inglês | MEDLINE | ID: mdl-27105491

17.

Pleomorphic characteristics of a germ-line KIT mutation in a large kindred with gastrointestinal stromal tumors, hyperpigmentation, and dysphagia.

Robson, Mark E; Glogowski, Emily; Sommer, Gunhild; Antonescu, Cristina R; Nafa, Khedoudja; Maki, Robert G; Ellis, Nathan; Besmer, Peter; Brennan, Murray; Offit, Kenneth.

Clin Cancer Res ; 10(4): 1250-4, 2004 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-14977822

18.

Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior: KIT mutation analysis and clinical correlates of 120 gastrointestinal stromal tumors.

Antonescu, Cristina R; Sommer, Gunhild; Sarran, Lisa; Tschernyavsky, Sylvia J; Riedel, Elyn; Woodruff, James M; Robson, Mark; Maki, Robert; Brennan, Murray F; Ladanyi, Marc; DeMatteo, Ronald P; Besmer, Peter.

Clin Cancer Res ; 9(9): 3329-37, 2003 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-12960119

19.

Loss of expression and function of SOCS3 is an early event in HNSCC: altered subcellular localization as a possible mechanism involved in proliferation, migration and invasion.

Rossa, Carlos; Sommer, Gunhild; Spolidorio, Luis C; Rosenzweig, Steven A; Watson, Dennis K; Kirkwood, Keith L.

PLoS One ; 7(9): e45197, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-23028842

20.

Implication of RNA-binding protein La in proliferation, migration and invasion of lymph node-metastasized hypopharyngeal SCC cells.

Sommer, Gunhild; Rossa, Carlos; Chi, Angela C; Neville, Brad W; Heise, Tilman.

PLoS One ; 6(10): e25402, 2011.

Artigo em Inglês | MEDLINE | ID: mdl-22016766

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