RESUMO
7-Arylamino-5,8-dioxo-5,8-dihydroisoquinoline-4-carboxylates were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Most of tested compounds showed good antifungal activity. The results suggest that those 5,8-dioxo-5,8-dihydroisoquinolines would be potent antifungal agents.
Assuntos
Antifúngicos/farmacologia , Aspergillus/efeitos dos fármacos , Candida/efeitos dos fármacos , Ácidos Carboxílicos/farmacologia , Cryptococcus neoformans/efeitos dos fármacos , Isoquinolinas/farmacologia , Antifúngicos/síntese química , Antifúngicos/química , Candida/classificação , Ácidos Carboxílicos/síntese química , Ácidos Carboxílicos/química , Relação Dose-Resposta a Droga , Isoquinolinas/síntese química , Isoquinolinas/química , Testes de Sensibilidade Microbiana , Estrutura Molecular , Relação Estrutura-AtividadeRESUMO
Pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones would be potent antifungal agents.
Assuntos
Antifúngicos/farmacologia , Carbolinas/síntese química , Química Farmacêutica/métodos , Aspergillus flavus/metabolismo , Aspergillus niger/metabolismo , Candida albicans/metabolismo , Carbolinas/farmacologia , Desenho de Fármacos , Fungos/efeitos dos fármacos , Indóis/química , Testes de Sensibilidade Microbiana , Modelos Químicos , Saccharomyces cerevisiae/metabolismo , Fatores de TempoRESUMO
Benzofuran-5-ol derivatives were synthesized and tested for in vitro antifungal activity against Candida, Aspergillus species, and Cryptococcus neoformans. Among them tested, many benzofuran-5-ols showed good antifungal activity. The results suggest that benzofuran-5-ols would be promising antifungal agents.
Assuntos
Antifúngicos/síntese química , Antifúngicos/farmacologia , Benzofuranos/síntese química , Benzofuranos/farmacologia , Aspergillus/efeitos dos fármacos , Candida/efeitos dos fármacos , Cryptococcus neoformans/efeitos dos fármacos , Testes de Sensibilidade MicrobianaRESUMO
Benzo[d]oxazole-4,7-diones were synthesized and tested for in vitro antifungal activity against fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that benzo[d]oxazole-4,7-diones would be potent antifungal agents.