RESUMO
Transmetalation is a key step in traditional coupling reactions. Herein we discuss the most recent progress in the metal-metal relay catalysis based on a transmetalation strategy. An efficient synthetic strategy for the formation of polysubstituted furan derivatives from cyclopropenes based on the tandem metal relay catalysis (TMRC reaction) is summarized.
RESUMO
A modular synthesis of tetrasubstituted furan carboxylates using a tandem cycloisomerization/oxidative carbonylation sequence of cyclopropenes has been successfully developed. The Tandem Metal Relay Catalysis (TMRC) pathway accounted for the high efficiency of this transformation.
Assuntos
Alcenos/química , Furanos/síntese química , Monóxido de Carbono/química , Catálise , Cobre/química , Ciclização , Estrutura Molecular , Oxirredução , Paládio/químicaRESUMO
A Cu/Pd-catalyzed, three-component click reaction of azide, alkyne, and aryl halide has been developed. By using this Cu/Pd transmetalation relay catalysis, a variety of 1,4,5-trisubstituted 1,2,3-triazoles were quickly assembled in one step in high yields with complete regioselectivity, just like assembling Lego bricks. Notably, different from the well-established CuAAC click reactions only working on terminal alkynes, this reaction offers an alternative solution for the problem of the click reaction of internal alkynes.
Assuntos
Alcinos/química , Azidas/química , Hidrocarbonetos Halogenados/química , Triazóis/síntese química , Catálise , Química Click , Cobre , Estrutura Molecular , Paládio , Triazóis/químicaRESUMO
An efficient synthesis of bifurans via dimerization of cyclopropenes has been successfully developed using a copper-promoted cycloisomerization and palladium-catalyzed dimerization cascade. These novel bifuran structures possess interesting optoelectronic properties.