Curettage combined with decompression for the treatment of ameloblastoma in children: report of two cases.

BACKGROUND: Ameloblastoma (AM) is the most common benign odontogenic tumor, which is more often detected in the mandible than maxilla, especially the mandibular body and mandibular angle. Pediatric AM is a rare disease, especially in patients aged 10 and younger. Compared with the mainstream osteotomy and reconstructive surgery for adult ameloblastoma, there is more room for discussion in the treatment of pediatric ameloblastoma. The postoperative functional and psychological influence can not be ignored. Especially for children in the period of growth and development, an osteotomy is often challenging to be accepted by their parents. We report two patients with ameloblastoma under 10 years old who are treated with curettage and fenestration, which is a beneficial method for children with ameloblastoma. CASE PRESENTATION: We present two cases of classic ameloblastoma in children. We describe in detail the patients' characteristics, treatment processes, and follow-up result. The bone formation and reconstruction in the lesion area after fenestration decompression and curettage are recorded at every clinic review. The surgical details and principles of curettage and decompression are also described and discussed. The two patients have good bone shape recovery and no recurrence. CONCLUSIONS: Children are in the growth and development period and possess an extremely strong ability of bone formation and reconstruction. Based on the principles of minimally invasive and functional preservation, we believe that curettage combined with decompression can be the first choice for treating AM in children, especially for mandibular lesions.

Rare Occipital Artery Pseudoaneurysm After Radical Neck Dissection.

Pseudoaneurysm formation in the occipital artery, post radical neck dissection, leading to a bulging mass, is a rare but potentially fatal occurrence. The authors treated a patient with pseudoaneurysm of occipital artery, post radical neck dissection, presenting with pain and swelling after 17 days of surgery. A pseudoaneurysm involving occipital artery was revealed by digital subtraction angiography and treated by endovascular micro-coil embolization.

An Immunosensor Using Electroactive COF as Signal Probe for Electrochemical Detection of Carcinoembryonic Antigen.

Two kinds of two-dimensional (2D) covalent-organic frameworks (COF) were used to construct a sandwich-type electrochemical immunosensor for a proof-of-concept study. Vinyl-functionalized COFTab-Dva could be linked with Ab1 by the thiol-ene "click" reaction. Electroactive COFTFPB-Thi was modified with gold nanoparticles (AuNPs) to ensure the successful connection with Ab2 through Au-S bond. Meanwhile, electroactive COFTFPB-Thi was used to as signal probe to realize both the detection of carcinoembryonic antigen (CEA) and the amplification of detection signal. In detection process of the sandwich-type electrochemical immunosensor, glassy carbon electrode (GCE) was modified with 2D COFTab-Dva first then connected with Ab1 by the thiol-ene "click" reaction, next quantitative CEA was captured, followed by specificially capturing signal probe of Ab2/AuNPs/COFTFPB-Thi where AuNPs acted as nanocarriers of Ab2 and COFTFPB-Thi served as the signal producers. As the amount of CEA was increased, the amount of signal probe captured to the electrode was also increased, and the peak signal intensity of the redox reaction of COFTFPB-Thi was enhanced accordingly. Thus, the quantitative detection of CEA could be realized according to the peak signal intensity of electroactive COFTFPB-Thi. The electrochemical immunosensor owned wide detection range of 0.11 ng/mL-80 ng/mL, low detection limit of 0.034 ng/mL and good practicability. This study opens up a new revelation for quantitative detection of CEA using electroactive COF as enhanced signal probe.

Preparation of co-Co3 O4 /carbon nanotube/carbon foam for glucose sensor.

Co-Co3 O4 /carbon nanotube/carbon foam (Co-Co3 O4 /CNT/CF) nanocomposites were prepared by soaking melamine foam into a solution of Co(NO3 )2 ·6H2 O, followed by calcination in N2 and air in sequence. The obtained Co-Co3 O4 /CNT/CF nanocomposites were characterized with scanning electron microscopy and cyclic voltammetry. It was found that Co3 O4 nanoparticles were grown on the external of CF successfully, while CNTs were grown on the surfaces of CF in a large amount, which further improved the electrical conductivity of the. The prepared Co-Co3 O4 /CNT/CF nanocomposites were then used to construct nonenzymatic sensor to detect glucose in alkaline solution. The sensor showed detection range from 1.2 µM to 2.29 mM with a detection limit of 0.4 µM (S/N =3) and a high sensitivity of 637.5 µA-1 cm-2 . The developed sensor also showed an instant response, favorable reproducibility, and high selectivity. The results attest that Co-Co3 O4 /CNT/CF composites have great potential in the development of nonenzymatic sensors for glucose.

Ratiometric fluorescent detection of Cu2+ based on dual-emission ZIF-8@rhodamine-B nanocomposites.

Zeolitic imidazolate framework-8 (ZIF-8) loading rhodamine-B (ZIF-8@rhodamine-B) nanocomposites was proposed and used as ratiometric fluorescent sensor to detect copper(II) ion (Cu2+ ). Scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray powder diffraction, nitrogen adsorption/desorption isotherms and fluorescence emission spectroscopy were employed to characterize the ZIF-8@rhodamine-B nanocomposites. The results showed the rhodamine-B was successfully assembled on ZIF-8 based on the π-π interaction and the hydrogen bond between the nitrogen atom of ZIF-8 and -COOH of rhodamine-B. The as-obtained ZIF-8@rhodamine-B nanocomposites were octahedron with size about 150-200 nm, had good water dispersion, and exhibited the characteristic fluorescence emission of ZIF-8 at 335 nm and rhodamine-B at 575 nm. The Cu2+ could quench fluorescence of ZIF-8 rather than rhodamine-B. The ZIF-8 not only acted as the template to assemble rhodamine-B, but also was employed as the signal fluorescence together with the fluorescence of rhodamine-B as the reference to construct a novel ratiometric fluorescent sensor to detect Cu2+ . The resulted ZIF-8@rhodamine-B nanocomposite fluorescence probe showed good linear range (68.4 nM to 125 µM) with a low detection limit (22.8 nM) for Cu2+ combined with good sensitivity and selectivity. The work also provides a better way to design ratiometric fluorescent sensors from ZIF-8 and other fluorescent molecules.

Ratiometric fluorescence detection of superoxide anion based on AuNPs-BSA@Tb/GMP nanoscale coordination polymers.

A novel ratiometric fluorescence nanosensor for superoxide anion (O2•- ) detection was designed with gold nanoparticles-bovine serum albumin (AuNPs-BSA)@terbium/guanosine monophosphate disodium (Tb/GMP) nanoscale coordination polymers (NCPs) (AuNPs-BSA@Tb/GMP NCPs). The abundant hydroxyl and amino groups of AuNPs-BSA acted as binding points for the self-assembly of Tb3+ and GMP to form core-shell AuNPs-BSA@Tb/GMP NCP nanosensors. The obtained probe exhibited the characteristic fluorescence emission of both AuNPs-BSA and Tb/GMP NCPs. The AuNPs-BSA not only acted as a template to accelerate the growth of Tb/GMP NCPs, but also could be used as the reference fluorescence for the detection of O2•- . The resulting AuNPs-BSA@Tb/GMP NCP ratiometric fluorescence nanosensor for the detection of O2•- demonstrated high sensitivity and selectivity with a wide linear response range (14 nM-10 µM) and a low detection limit (4.7 nM).

BSA-AuNPs@Tb-AMP metal-organic frameworks for ratiometric fluorescence detection of DPA and Hg2.

An easy and effective strategy for synthesizing a ratiometric fluorescent nanosensor has been demonstrated in this work. Novel fluorescent BSA-AuNPs@Tb-AMP (BSA, bovine serum albumin; AMP, adenosine 5'-monophosphate; AuNPs, Au nanoparticles) metal-organic framework (MOF) nanostructures were synthesized by encapsulating BSA-AuNPs into Tb-AMP MOFs for the detection of 2,6-pyridinedicarboxylic acid (DPA) and Hg2+ . DPA could strongly co-ordinate with Tb3+ to replace water molecules from the Tb3+ center and accordingly enhanced the fluorescence of Tb-AMP MOFs. The fluorescence of BSA-AuNPs at 405 nm remained constant. While the fluorescence of BSA-AuNPs at 635 nm was quenched after Hg2+ was added, the fluorescence of Tb-AMP MOFs remained constant. Accordingly, a ratiometric fluorescence nanosensor was constructed for detection of DPA and Hg2+ . The ratiometric nanosensor exhibited good selectivity to DPA over other substances. The F545 /F405 linearly increased with increase of DPA concentration in the range of 50 nM to 10 µM with a detection limit as low as 17.4 nM. F635 /F405 increased linearly with increase of Hg2+ concentration ranging from 50 nM to 1 µM with a detection limit as low as 20.9 nM. Additionally, the nanosensor could be successfully applied for the determination of DPA and Hg2+ in running water.

Nitrogen-Doped Carbon Nanotubes Supported by Macroporous Carbon as an Efficient Enzymatic Biosensing Platform for Glucose.

Effective immobilization of enzymes/proteins on an electrode surface is very essential for biosensor development, but it still remains challenging because enzymes/proteins tend to form close-packed structures on the electrode surface. In this work, nitrogen-doped carbon nanotubes (NCNTs) supported by three-dimensional Kenaf Stem-derived porous carbon (3D-KSC) (denoted as 3D-KSC/NCNTs) nanocomposites were constructed as the supporting matrix to load glucose oxidase (GOD) for preparing integrated glucose biosensors. These NCNTs are vertically arrayed on the channel walls of the 3D-KSC via the chemical vapor deposition method, which could noticeably increase the effective surface area, mechanical stability, and active sites (originating from the doped nitrogen) of the nanocomposites. The integrated glucose biosensor exhibits some advantages over the traditional GOD electrodes in terms of the capability to promote the direct electron transfer of GOD, enhance the mechanical stability of the biosensor attributed to the strong interaction between NCNTs and GOD, and enlarge the specific surface area to efficiently load a large number of GODs. The as-prepared biosensor shows a good performance toward both oxygen reduction and glucose biosensing. This study essentially offers a novel approach for the development of biosensors with excellent analytical properties.

Fabrication of fluorescent SiO2@zeolitic imidazolate framework-8 nanosensor for Cu(2+) detection.

A simple strategy to fabricate a fluorescent SiO2@zeolitic imidazolate framework-8 (ZIF-8) core-shell nanosensor for Cu(2+) detection was demonstrated in this work. The nanosensor was synthesized using carboxyl-functionalized SiO2 nanoparticles (SiO2 NPs) as a template to induce the growth of ZIF-8 on its surface. The porous SiO2@ZIF-8 exhibited extremely good adsorption properties and a large specific surface area to accumulate Cu(2+), and the pyridyl nitrogen sites in imidazole played vital roles in the recognition of Cu(2+). The fluorescent intensity decreased linearly with the increasing of Cu(2+) concentration in the range of 10-500 nM and the detection limit was estimated to be 3.8 nM. The SiO2@ZIF-8 nanosensor could be further used to determine trace amounts of Cu(2+) in real water samples, while some previous sensors had to be dispersed in organic solution for use, such as DMSO and MeCN. The core-shell nanostructures of SiO2@ZIF-8 made it possible for it to be dispersed directly in aqueous solution and prevented ZIF-8 from aggregation, which enhanced the sensing performance of the SiO2@ZIF-8 nanosensor.

A glucose biosensor based on glucose oxidase immobilized on three-dimensional porous carbon electrodes.

A novel glucose biosensor was developed by immobilizing glucose oxidase (GOD) on a three-dimensional (3D) porous kenaf stem-derived carbon (3D-KSC) which was firstly proposed as a novel supporting material to load biomolecules for electrochemical biosensing. Here, an integrated 3D-KSC electrode was prepared by using a whole piece of 3D-KSC to load the GOD molecules for glucose biosensing. The morphologies of integrated 3D-KSC and 3D-KSC/GOD electrodes were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The SEM results revealed a 3D honeycomb macroporous structure of the integrated 3D-KSC electrode. The TEM results showed some microporosities and defects in the 3D-KSC electrode. The electrochemical behaviors and electrocatalytic performance of the integrated 3D-KSC/GOD electrode were evaluated by cyclic voltammetry and electrochemical impedance spectroscopy. The effects of pH and scan rates on the electrochemical response of the biosensor have been studied in detail. The glucose biosensor showed a wide linear range from 0.1 mM to 14.0 mM with a high sensitivity of 1.73 µA mM(-1) and a low detection limit of 50.75 µM. Furthermore, the glucose biosensor exhibited high selectivity, good repeatability and reproducibility, and good stability.

pH-switchable electrochemical sensing platform based on chitosan-reduced graphene oxide/concanavalin a layer for assay of glucose and urea.

A facile and effective electrochemical sensing platform for the detection of glucose and urea in one sample without separation was developed using chitosan-reduced graphene oxide (CS-rGO)/concanavalin A (Con A) as a sensing layer. The CS-rGO/Con A with pH-dependent surface net charges exhibited pH-switchable response to negatively charged Fe(CN)6(3-). The principle for glucose and urea detection was essentially based on in situ pH-switchable enzyme-catalyzed reaction in which the oxidation of glucose catalyzed by glucose oxidase or the hydrolyzation of urea catalyzed by urease resulted in a pH change of electrolyte solution to give different electrochemical responses toward Fe(CN)6(3-). It was verified by cyclic voltammograms, differential pulse voltammograms, and electrochemical impedance spectroscopy. The resistance to charge transfer or amperometric current changed proportionally toward glucose concentration from 1.0 to 10.0 mM and urea concentration from 1.0 to 7.0 mM. On the basis of human serum experiments, the sensing platform was proved to be suitable for simultaneous assay of glucose and urea in a practical biosystem. This work not only gives a way to detect glucose and urea in one sample without separation but also provides a potential strategy for the detection of nonelectroactive species based on the enzyme-catalyzed reaction and pH-switchable biosensor.

Electrochemical sensing and biosensing platform based on biomass-derived macroporous carbon materials.

A three-dimensional (3D) macroporous carbon (3D-KSCs) derived from kenaf stem (KS) is proposed as a novel supporting material for electrochemical sensing and a biosensing platform. A series of 3D-KSCs/inorganic nanocomposites such as Prussian blue (PB) nanoparticles (NPs)-carboxylic group-functionalized 3D-KSCs (PBNPs-3D-FKSCs), CuNiNPs-3D-KSCs, and CoNPs-3D-KSCs were prepared by a facile two-step route consisting of carbonization and subsequent chemical synthesis or one-step carbonization of KS-metal ion complex. The obtained 3D-KSCs/inorganic nanocomposites were characterized by X-ray diffraction, X-ray photoelectron spectroscopy, energy dispersive X-ray spectroscopy, scanning electron microscopy, and Fourier transform-infrared spectroscopy. A whole piece of 3D-KSCs/nanocomposites was used to prepare an integrated 3D-KSCs/nanocomposite electrode. Compared to the electrode modified by graphene, carbon nanotubes and their derivatives, which can form close-packed structure after assembled on electrode surface, the integrated 3D-KSCs/nanocomposite electrode shows a 3D honeycomb porous structure. Such structure provides a large specific surface area, effectively supports a large number of electro-active species, and greatly enhances the mass and electron transfer. The electrochemical behaviors and electrocatalytic performances of the integrated 3D-KSCs/inorganic nanocomposite electrode were evaluated by cyclic voltammetry and the amperometric method. The resulted PBNPs-3D-FKSCs, CuNiNPs-3D-KSCs, and CoNPs-3D-KSCs electrode show good electrocatalytic performances toward the reduction of H2O2, the oxidation of glucose and amino acid, respectively. Therefore, the low-cost, renewable, and environmentally friendly 3D-KSCs should be promising supporting materials for an electrochemical sensor and biosensor.

Metal-organic framework-derived copper nanoparticle@carbon nanocomposites as peroxidase mimics for colorimetric sensing of ascorbic acid.

Metal-organic frameworks (MOFs) have emerged as very fascinating functional materials due to their diversity nature. A nanocomposite consisting of copper nanoparticles dispersed within a carbon matrix (Cu NPs@C) is prepared through a one-pot thermolysis of copper-based metal-organic framework precursors. Cu NPs@C can catalyze the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) to form a colored product in the presence of H2 O2 . As a peroxidase mimic, Cu NPs@C not only has the advantages of low cost, high stability, and easy preparation, but also follows Michaelis-Menten behaviors and shows strong affinity to H2 O2 . As the Cu NPs' surfaces are free from stabilizing agent, Cu NPs@C exhibited a higher affinity to H2 O2 than horseradish peroxidase. On the basis of the inhibitory effect of ascorbic acid (AA) on oxidation of TMB, this system serves as a colorimetric method for the detection of AA, suggesting that the present work would expand the potential applications of MOF-derived nanocomposites in biomedical fields.

Functionalized lanthanide coordination polymer nanoparticles for selective sensing of hydrogen peroxide in biological fluids.

Lanthanide coordination polymers have recently emerged as very fascinating sensing materials due to their tunable structures and unique optical properties. However, a major problem concerning the applications of lanthanide coordination polymers for fluorescent sensing is their unselective recognition to analytes. In this work, a direct post-modification strategy was employed to prepare functionalized lanthanide coordination polymer nanoparticles (Phe/Tb-CPBA CPNPs) with specific response ability to hydrogen peroxide (H2O2) by using phenylalanine (Phe) as bridging ligands, terbium ions (Tb(3+)) as metal nodes and carboxyphenylboronic acids (CPBAs) as guest ligands. Phe/Tb-CPBA CPNPs emit a strong green fluorescence due to the removal of coordinated water molecules and the sensitization effect of CPBA. Upon the addition of H2O2, however, the quenched fluorescence of Phe/Tb-CPBA CPNPs can be observed owing to an intramolecular charge transfer effect. This finding led to a method for the quantitation of H2O2 in the 6 µM to 1 mM concentration range and with a detection limit at 2 µM. Because of the chemoselective H2O2-mediated oxidative deboronation, Phe/Tb-CPBA CPNPs as fluorescent sensors exhibit excellent selectivity to H2O2. Furthermore, Phe/Tb-CPBA CPNPs were successfully used to measure the level of H2O2 in urine samples and showed satisfactory results. We envision that the presented strategy could be extended to design other functionalized coordination polymers with desired functions for various biomedical applications.

Binding characteristics and interactive region of 2-phenylpyrazolo[1,5-c]quinazoline with DNA.

The interaction between 2-phenylpyrazolo[1,5-c]quinazoline (PQ) and DNA under physiological conditions was investigated using multi-spectroscopic techniques, atomic force microscopy and gel electrophoresis. The thermodynamic parameters were estimated and were discussed in detail. The results of fluorescence-quenching experiments indicated that the main interactive force between PQ and DNA was a hydrophobic interaction and that it was a static quenching process. Potassium iodide and single-strand (ss)DNA quenching studies, together with circular dichroism spectra implied groove binding of PQ with DNA. Atomic force microscopy and gel electrophoresis experiments suggested that there were no major conformational changes in DNA upon interaction with PQ. In addition, UV/vis absorption titration of DNA bases confirmed that PQ bound with DNA mainly through a minor groove interaction and preferentially interacted with adenine and thymine. We anticipate that this work will provide useful information for the application of quinazoline derivatives in the fields of medicinal and pharmaceutical chemistry.

Yolk shell structured YS-Si@N-doped carbon derived from covalent organic frameworks for enhanced lithium storage.

Silicon (Si) has ultra-high theoretical capacity (4200 mAh g-1) and accordingly is widely studied as anode materials for lithium-ion batteries (LIBs). However, its huge volume expansion during charging/discharging is a fatal challenge. The preparation of Si-based composite materials with yolk shell structure is the key to solving the Si volume expansion. Here, N-doped carbon-coated Si nanoparticles (SiNPs) nanocomposites (YS-Si@NC-60) with yolk shell structure derived from covalent organic frameworks (COFs) was prepared. N-doped carbon shells derived from COFs not only maintain the well-ordered nanosized pores of COFs, which facilitates the transport of Li+ to contact with internal SiNPs, but also provide more extra active sites for Li+ storage. Most importantly, the internal void can effectively alleviate the damage effect of SiNPs volume expansion. The obtained YS-Si@NC-60 as a LIBs anode show high cyclic stability and Li+ storage performances. At 0.1 A g-1, the capacity is 1446 mAh g-1 after 110 cycles, and initial coulomb efficiency is as high as 82.2 %. The excellent performance can be attributed to the unique yolk shell structure. This simple and template-free strategy provides a new idea for preparing Si-C nanocomposites with yolk shell structure.

A "turn-on" fluorescent sensor based on three-component covalent organic framework for trace water detection.

Trace amount of H2O is difficult to eliminate in laboratory environments and chemical industries as impurities. In some chemical reactions, trace amount of H2O can alter final reaction products, yield, and selectivity. So, the detection of trace H2O is very important. Herein, a series of TFPT[X]-BMTH- covalent organic frameworks (COFs) (X = 0, 33, 50, 67, 100 %) with intramolecular charge transfer effect (ICT) and aggregate-induced emission (AIE) characteristics were synthesized by amino-aldehyde condensation reaction between 2,5-bis(2-methoxyethoxy)terephthalohydrazide (BMTH)/ 1,3,5-tris(p-formylphenyl)benzene (TFPB) and 4,4',4''-(1,3,5-triazine-2,4,6-triyl)tribenzaldehyde (TFPT). By changing TFPT' content in TFPT[X]-BMTH-COFs, the ICT and AIE of TFPT[X]-BMTH-COFs can be controlled, and accordingly the response to trace H2O can be adjusted. A H2O sensor based on TFPT[67]-BMTH-COF with a wide linear range from 0 wt% to 0.5 wt% was developed and the detection limit was 0.00007 wt%. In addition, a portable fluorescent test paper based on TFPT[67]-BMTH-COF for visual detection of trace H2O in honey samples and salt was constructed. This work has important guiding significance for the development of fluorescent probes for the visual detection of trace water.

A fluorescent covalent organic framework for visual detection of p-benzoquinone.

P-benzoquinone (PBQ) is toxic and harmful for health. The development of portable sensor to realize the detection of PBQ is of great significance. Herein, a novel covalent organic framework (COFML-TFPB) with intramolecular charge transfer and aggregation induced emission properties was proposed via condensation reaction of melem (ML) and 1,3,5-tris (4-formylphenyl) benzene (TFPB). COFML-TFPB shows strong fluorescence in both solution and solid state and can be used for the fluorescence detection of PBQ. Due to the internal filtration effect and photoinduced electron transfer effect, PBQ can quench the fluorescence of COFML-TFPB. The developed COFML-TFPB fluorescent sensor displayed a wide linear range for PBQ from 0.138 ng mL-1 - 35 µg mL-1, and the detection limit was 0.046 ng mL-1. In addition, fluorescent test paper for rapid and portable detection of PBQ was also developed by depositing COFML-TFPB on filter paper directly. It reduces the cost and time of detection and realizes the semiquantitative detection of PBQ. Moreover, the fluorescence color was converted into digital RGB value to calculate the concentration of PBQ accurately by a smartphone. This method realizes the portable qualitative and semiquantitative determination of PBQ.

Si@nitrogen-doped porous carbon derived from covalent organic framework for enhanced Li-storage.

Due to ultra-high theoretical capacity (4200 mAh g-1), silicon (Si) is an excellent candidate for the anode of lithium-ion batteries (LIBs). However, the application of Si is severely limited by its volume expansion of approximately 300% during the charge/discharge process. Herein, nitrogen-doped porous carbon (NC) capped nano-Si particles (Si@NC) composites with a core-shell structure were obtained by calcination of covalent organic frameworks (COFs) encapsulated nano-Si. COFs is a crystalline material with well-ordered structures, adjustable and ordered pores and abundant N atoms. After carbonization, the well-ordered pores and frameworks were kept well. Compared with other Si@NC composites, the well-ordered NC framework shell derived from COFs possesses high elasticity and well-ordered pores, which provides space for the volume expansion of nano-Si, and a channel to transfer Li+. The core-shell Si@NC composite exhibited good performances when applied as the anode of LIBs. At a current density of 100 mA g-1, it exhibited a discharge-specific capacity of 1534.8 mAh g-1 after 100 cycles with a first-coulomb efficiency of 69.7%. The combination of COFs with nano-Si is a better strategy for the preparation of anode materials of LIBs.

S,N-rich luminous covalent organic frameworks for Hg2+ detection and removal.

The challenge for simultaneous detection and removal of Hg2+ is the design of bifunctional materials bearing abundant accessible chelating sites with high affinity. Covalent-organic frameworks (COFs) are attracting more and more attention as potential bifunctional materials for Hg2+ detection due to their large specific surface area, ordered pores, and abundant chelating sites. Here, a new luminous S,N-rich COFBTT-AMPD based on hydrophilic block unit of 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AMPD) was constructed, which improved the solubility and affinity for Hg2+ greatly. Another S-rich fused-ring unit of benzotrithiophene tricarbalaldehyde (BTT) enhanced the conjugation of COFBTT-AMPD, and the methyl-rich chains block unit of AMPD effectively suppressed the aggregation-caused quenching. Thus, the COFBTT-AMPD emitted strong fluorescence at 546 nm in liquid and solid as well as different solvent with a wide pH range, which was used for the visual detection and removal of Hg2+ (detection limit: 2.6 nM, linear range: 8.6 × 10-3-20 µM, monolayer adsorption capacity: 476.19 mg g-1) successfully. COFBTT-AMPD-based fabric and light-emitting diode coatings were further constructed to realize the visual detection of Hg2+ vapor. The results reveal the potential of S,N-rich luminous COFBTT-AMPD for Hg2+ detection and remediation in the environment.