Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Transcriptome dynamics of CD4⁺ T cells during malaria maps gradual transit from effector to memory.

Soon, Megan S F; Lee, Hyun Jae; Engel, Jessica A; Straube, Jasmin; Thomas, Bryce S; Pernold, Clara P S; Clarke, Lachlan S; Laohamonthonkul, Pawat; Haldar, Rohit N; Williams, Cameron G; Lansink, Lianne I M; Moreira, Marcela L; Bramhall, Michael; Koufariotis, Lambros T; Wood, Scott; Chen, Xi; James, Kylie R; Lönnberg, Tapio; Lane, Steven W; Belz, Gabrielle T; Engwerda, Christian R; Khoury, David S; Davenport, Miles P; Svensson, Valentine; Teichmann, Sarah A; Haque, Ashraful.

Nat Immunol ; 21(12): 1597-1610, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-33046889

2.

The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation.

Ng, Susanna S; De Labastida Rivera, Fabian; Yan, Juming; Corvino, Dillon; Das, Indrajit; Zhang, Ping; Kuns, Rachel; Chauhan, Shashi Bhushan; Hou, Jiajie; Li, Xian-Yang; Frame, Teija C M; McEnroe, Benjamin A; Moore, Eilish; Na, Jinrui; Engel, Jessica A; Soon, Megan S F; Singh, Bhawana; Kueh, Andrew J; Herold, Marco J; Montes de Oca, Marcela; Singh, Siddharth Sankar; Bunn, Patrick T; Aguilera, Amy Roman; Casey, Mika; Braun, Matthias; Ghazanfari, Nazanin; Wani, Shivangi; Wang, Yulin; Amante, Fiona H; Edwards, Chelsea L; Haque, Ashraful; Dougall, William C; Singh, Om Prakash; Baxter, Alan G; Teng, Michele W L; Loukas, Alex; Daly, Norelle L; Cloonan, Nicole; Degli-Esposti, Mariapia A; Uzonna, Jude; Heath, William R; Bald, Tobias; Tey, Siok-Keen; Nakamura, Kyohei; Hill, Geoffrey R; Kumar, Rajiv; Sundar, Shyam; Smyth, Mark J; Engwerda, Christian R.

Nat Immunol ; 21(10): 1205-1218, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32839608

3.

Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation.

Ng, Susanna S; De Labastida Rivera, Fabian; Yan, Juming; Corvino, Dillon; Das, Indrajit; Zhang, Ping; Kuns, Rachel; Chauhan, Shashi Bhushan; Hou, Jiajie; Li, Xian-Yang; Frame, Teija C M; McEnroe, Benjamin A; Moore, Eilish; Na, Jinrui; Engel, Jessica A; Soon, Megan S F; Singh, Bhawana; Kueh, Andrew J; Herold, Marco J; Montes de Oca, Marcela; Singh, Siddharth Sankar; Bunn, Patrick T; Aguilera, Amy Roman; Casey, Mika; Braun, Matthias; Ghazanfari, Nazanin; Wani, Shivangi; Wang, Yulin; Amante, Fiona H; Edwards, Chelsea L; Haque, Ashraful; Dougall, William C; Singh, Om Prakash; Baxter, Alan G; Teng, Michele W L; Loukas, Alex; Daly, Norelle L; Cloonan, Nicole; Degli-Esposti, Mariapia A; Uzonna, Jude; Heath, William R; Bald, Tobias; Tey, Siok-Keen; Nakamura, Kyohei; Hill, Geoffrey R; Kumar, Rajiv; Sundar, Shyam; Smyth, Mark J; Engwerda, Christian R.

Nat Immunol ; 25(4): 716, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38360937

4.

Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells.

Akter, Jasmin; Khoury, David S; Aogo, Rosemary; Lansink, Lianne I M; SheelaNair, Arya; Thomas, Bryce S; Laohamonthonkul, Pawat; Pernold, Clara P S; Dixon, Matthew W A; Soon, Megan S F; Fogg, Lily G; Engel, Jessica A; Elliott, Trish; Sebina, Ismail; James, Kylie R; Cromer, Deborah; Davenport, Miles P; Haque, Ashraful.

PLoS Pathog ; 15(2): e1007599, 2019 02.

Artigo em Inglês | MEDLINE | ID: mdl-30811498

5.

Recent Insights into CD4⁺ Th Cell Differentiation in Malaria.

Soon, Megan S F; Haque, Ashraful.

J Immunol ; 200(6): 1965-1975, 2018 03 15.

Artigo em Inglês | MEDLINE | ID: mdl-29507121

6.

IFN Regulatory Factor 3 Balances Th1 and T Follicular Helper Immunity during Nonlethal Blood-Stage Plasmodium Infection.

James, Kylie R; Soon, Megan S F; Sebina, Ismail; Fernandez-Ruiz, Daniel; Davey, Gayle; Liligeto, Urijah N; Nair, Arya Sheela; Fogg, Lily G; Edwards, Chelsea L; Best, Shannon E; Lansink, Lianne I M; Schroder, Kate; Wilson, Jane A C; Austin, Rebecca; Suhrbier, Andreas; Lane, Steven W; Hill, Geoffrey R; Engwerda, Christian R; Heath, William R; Haque, Ashraful.

J Immunol ; 200(4): 1443-1456, 2018 02 15.

Artigo em Inglês | MEDLINE | ID: mdl-29321276

7.

Host-mediated impairment of parasite maturation during blood-stage Plasmodium infection.

Khoury, David S; Cromer, Deborah; Akter, Jasmin; Sebina, Ismail; Elliott, Trish; Thomas, Bryce S; Soon, Megan S F; James, Kylie R; Best, Shannon E; Haque, Ashraful; Davenport, Miles P.

Proc Natl Acad Sci U S A ; 114(29): 7701-7706, 2017 07 18.

Artigo em Inglês | MEDLINE | ID: mdl-28673996

8.

Development of a Novel CD4⁺ TCR Transgenic Line That Reveals a Dominant Role for CD8⁺ Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria.

Fernandez-Ruiz, Daniel; Lau, Lei Shong; Ghazanfari, Nazanin; Jones, Claerwen M; Ng, Wei Yi; Davey, Gayle M; Berthold, Dorothee; Holz, Lauren; Kato, Yu; Enders, Matthias H; Bayarsaikhan, Ganchimeg; Hendriks, Sanne H; Lansink, Lianne I M; Engel, Jessica A; Soon, Megan S F; James, Kylie R; Cozijnsen, Anton; Mollard, Vanessa; Uboldi, Alessandro D; Tonkin, Christopher J; de Koning-Ward, Tania F; Gilson, Paul R; Kaisho, Tsuneyasu; Haque, Ashraful; Crabb, Brendan S; Carbone, Francis R; McFadden, Geoffrey I; Heath, William R.

J Immunol ; 199(12): 4165-4179, 2017 12 15.

Artigo em Inglês | MEDLINE | ID: mdl-29084838

9.

IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection.

Sebina, Ismail; James, Kylie R; Soon, Megan S F; Fogg, Lily G; Best, Shannon E; Labastida Rivera, Fabian de; Montes de Oca, Marcela; Amante, Fiona H; Thomas, Bryce S; Beattie, Lynette; Souza-Fonseca-Guimaraes, Fernando; Smyth, Mark J; Hertzog, Paul J; Hill, Geoffrey R; Hutloff, Andreas; Engwerda, Christian R; Haque, Ashraful.

PLoS Pathog ; 12(11): e1005999, 2016 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-27812214

10.

Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsets.

Dooley, Nicholas L; Chabikwa, Tinashe G; Pava, Zuleima; Loughland, Jessica R; Hamelink, Julianne; Berry, Kiana; Andrew, Dean; Soon, Megan S F; SheelaNair, Arya; Piera, Kim A; William, Timothy; Barber, Bridget E; Grigg, Matthew J; Engwerda, Christian R; Lopez, J Alejandro; Anstey, Nicholas M; Boyle, Michelle J.

Nat Commun ; 14(1): 7387, 2023 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-37968278

11.

Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites.

Lansink, Lianne I M; Skinner, Oliver P; Engel, Jessica A; Lee, Hyun Jae; Soon, Megan S F; Williams, Cameron G; SheelaNair, Arya; Pernold, Clara P S; Laohamonthonkul, Pawat; Akter, Jasmin; Stoll, Thomas; Hill, Michelle M; Talman, Arthur M; Russell, Andrew; Lawniczak, Mara; Jia, Xiaoxiao; Chua, Brendon; Anderson, Dovile; Creek, Darren J; Davenport, Miles P; Khoury, David S; Haque, Ashraful.

mBio ; 14(4): e0112923, 2023 08 31.

Artigo em Inglês | MEDLINE | ID: mdl-37449844

12.

Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children.

Oyong, Damian A; Loughland, Jessica R; Soon, Megan S F; Chan, Jo-Anne; Andrew, Dean; Wines, Bruce D; Hogarth, P Mark; Olver, Stuart D; Collinge, Alika D; Varelias, Antiopi; Beeson, James G; Kenangalem, Enny; Price, Ric N; Anstey, Nicholas M; Minigo, Gabriela; Boyle, Michelle J.

EBioMedicine ; 75: 103784, 2022 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-34968760

13.

T-follicular helper cells in malaria infection and roles in antibody induction.

Soon, Megan S F; Nalubega, Mayimuna; Boyle, Michelle J.

Oxf Open Immunol ; 2(1): iqab008, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-36845571

14.

Therapeutic vaccination with 4-1BB co-stimulation eradicates mouse acute myeloid leukemia.

Kerage, Daniel; Soon, Megan S F; Doff, Brianna L; Kobayashi, Takumi; Nissen, Michael D; Lam, Pui Yeng; Leggatt, Graham R; Mattarollo, Stephen R.

Oncoimmunology ; 7(10): e1486952, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-30288351

15.

Quantification of host-mediated parasite clearance during blood-stage Plasmodium infection and anti-malarial drug treatment in mice.

Aogo, Rosemary A; Khoury, David S; Cromer, Deborah; Elliott, Trish; Akter, Jasmin; Fogg, Lily G; Nair, Arya Sheela; Liligeto, Urijah N; Soon, Megan S F; Thomas, Bryce S; Pernold, Clara P S; Romanczuk, Aleksandra S; Laohamonthonkul, Pawat; Haque, Ashraful; Davenport, Miles P.

Int J Parasitol ; 48(12): 903-913, 2018 10.

Artigo em Inglês | MEDLINE | ID: mdl-30176235

16.

Therapeutic Efficacy of 4-1BB Costimulation Is Abrogated by PD-1 Blockade in a Model of Spontaneous B-cell Lymphoma.

McKee, Sara J; Doff, Brianna L; Soon, Megan S F; Mattarollo, Stephen R.

Cancer Immunol Res ; 5(3): 191-197, 2017 03.

Artigo em Inglês | MEDLINE | ID: mdl-28115358

17.

Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo.

Khoury, David S; Cromer, Deborah; Elliott, Trish; Soon, Megan S F; Thomas, Bryce S; James, Kylie R; Best, Shannon E; Aogo, Rosemary A; Engel, Jessica A; Gartlan, Kate H; Akter, Jasmin; Sebina, Ismail; Haque, Ashraful; Davenport, Miles P.

Int J Parasitol ; 47(14): 913-922, 2017 12.

Artigo em Inglês | MEDLINE | ID: mdl-28864033

18.

Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves Th1/Tfh fate bifurcation in malaria.

Lönnberg, Tapio; Svensson, Valentine; James, Kylie R; Fernandez-Ruiz, Daniel; Sebina, Ismail; Montandon, Ruddy; Soon, Megan S F; Fogg, Lily G; Nair, Arya Sheela; Liligeto, Urijah; Stubbington, Michael J T; Ly, Lam-Ha; Bagger, Frederik Otzen; Zwiessele, Max; Lawrence, Neil D; Souza-Fonseca-Guimaraes, Fernando; Bunn, Patrick T; Engwerda, Christian R; Heath, William R; Billker, Oliver; Stegle, Oliver; Haque, Ashraful; Teichmann, Sarah A.

Sci Immunol ; 2(9)2017 Mar 03.

Artigo em Inglês | MEDLINE | ID: mdl-28345074

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