Detalhe da pesquisa
1.
Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon.
Arch Toxicol
; 95(5): 1573-1593, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33715020
2.
Defining in vivo dose-response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach.
J Appl Toxicol
; 40(12): 1647-1660, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33034907
3.
The role of metabolism in the developmental toxicity of polycyclic aromatic hydrocarbon-containing extracts of petroleum substances.
J Appl Toxicol
; 40(3): 330-341, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31808176
4.
Study on inter-ethnic human differences in bioactivation and detoxification of estragole using physiologically based kinetic modeling.
Arch Toxicol
; 91(9): 3093-3108, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28357488
5.
Integrating in vitro data and physiologically based kinetic (PBK) modelling to assess the in vivo potential developmental toxicity of a series of phenols.
Arch Toxicol
; 91(5): 2119-2133, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-27815601
6.
Evaluation of the interindividual human variation in bioactivation of methyleugenol using physiologically based kinetic modeling and Monte Carlo simulations.
Toxicol Appl Pharmacol
; 283(2): 117-26, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25549870
7.
Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose-response curves for developmental toxicity of phenol in rat and human.
Arch Toxicol
; 87(9): 1709-23, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23943240
8.
Physiologically based kinetic modeling of bioactivation and detoxification of the alkenylbenzene methyleugenol in human as compared with rat.
Toxicol Appl Pharmacol
; 260(3): 271-84, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22445790
9.
Physiologically based kinetic models for the alkenylbenzene elemicin in rat and human and possible implications for risk assessment.
Chem Res Toxicol
; 25(11): 2352-67, 2012 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-22992039
10.
In vivo validation of DNA adduct formation by estragole in rats predicted by physiologically based biodynamic modelling.
Mutagenesis
; 27(6): 653-63, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22844077
11.
Use of Physiologically Based Pharmacokinetic Modeling to Predict Human Gut Microbial Conversion of Daidzein to S-Equol.
J Agric Food Chem
; 70(1): 343-352, 2022 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34855380
12.
Use of Physiologically Based Kinetic Modeling to Predict Rat Gut Microbial Metabolism of the Isoflavone Daidzein to S-Equol and Its Consequences for ERα Activation.
Mol Nutr Food Res
; 64(6): e1900912, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32027771
13.
Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf.
BMC Complement Med Ther
; 20(1): 80, 2020 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32164648
14.
Microfluidic chip for culturing intestinal epithelial cell layers: Characterization and comparison of drug transport between dynamic and static models.
Toxicol In Vitro
; 65: 104815, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-32119998
15.
Effects of Maerua subcordata (Gilg) DeWolf on electrophile-responsive element (EpRE)-mediated gene expression in vitro.
PLoS One
; 14(4): e0215155, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30986264
16.
Hazard assessment of Maerua subcordata (Gilg) DeWolf. for selected endpoints using a battery of in vitro tests.
J Ethnopharmacol
; 241: 111978, 2019 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31150796
17.
Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Red Blood Cell Acetylcholinesterase Inhibition Following Exposure to Chlorpyrifos in the Caucasian and Chinese Population.
Toxicol Sci
; 171(1): 69-83, 2019 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31214721
18.
Quercetin increases the bioavailability of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats.
Food Chem Toxicol
; 46(11): 3422-8, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18783729
19.
Development of a Combined In Vitro Physiologically Based Kinetic (PBK) and Monte Carlo Modelling Approach to Predict Interindividual Human Variation in Phenol-Induced Developmental Toxicity.
Toxicol Sci
; 157(2): 365-376, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28498972
20.
The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids.
Environ Toxicol Pharmacol
; 11(3-4): 321-33, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21782615