Detalhe da pesquisa
1.
Systemic efficacy on Cryptosporidium parvum infection of aminoxanide (RM-5061), a new amino-acid ester thiazolide prodrug of tizoxanide.
Parasitology
; 148(8): 975-984, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33775260
2.
Kinetic modelling of acyl glucuronide and glucoside reactivity and development of structure-property relationships.
Org Biomol Chem
; 18(7): 1389-1401, 2020 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32002533
3.
Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients.
J Pharmacol Exp Ther
; 350(2): 387-402, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24902585
4.
Transacylation and hydrolysis of the acyl glucuronides of ibuprofen and its α-methyl-substituted analogues investigated by 1H NMR spectroscopy and computational chemistry: Implications for drug design.
J Pharm Biomed Anal
; 246: 116238, 2024 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38805849
5.
The generation, detection, and effects of reactive drug metabolites.
Med Res Rev
; 33(5): 985-1080, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23090860
6.
Glucuronides from metabolites to medicines: a survey of the in vivo generation, chemical synthesis and properties of glucuronides.
Nat Prod Rep
; 30(6): 806-48, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23648894
7.
Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles.
Org Biomol Chem
; 11(48): 8426-34, 2013 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24193242
8.
A host-gut microbial amino acid co-metabolite, p-cresol glucuronide, promotes blood-brain barrier integrity in vivo.
Tissue Barriers
; 11(1): 2073175, 2023 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35596559
9.
Thiazolide Prodrug Esters and Derived Peptides: Synthesis and Activity.
ACS Bio Med Chem Au
; 3(4): 327-334, 2023 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37599793
10.
Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients.
J Pharmacol Exp Ther
; 338(3): 841-9, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21680886
11.
Synthesis of a series of phenylacetic acid 1-ß-O-acyl glucosides and comparison of their acyl migration and hydrolysis kinetics with the corresponding acyl glucuronides.
Org Biomol Chem
; 9(3): 926-34, 2011 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21152488
12.
Synthesis and toxicity profile in 293 human embryonic kidney cells of the ß D-glucuronide derivatives of ortho-, meta- and para-cresol.
Carbohydr Res
; 499: 108225, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-33353664
13.
Synthesis, antiviral activity, preliminary pharmacokinetics and structural parameters of thiazolide amine salts.
Future Med Chem
; 13(20): 1731-1741, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34402654
14.
Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2?
ACS Infect Dis
; 7(6): 1317-1331, 2021 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33352056
15.
Discovery and Optimization of a 4-Aminopiperidine Scaffold for Inhibition of Hepatitis C Virus Assembly.
J Med Chem
; 64(13): 9431-9443, 2021 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34184537
16.
Structure-based mechanism of CMP-2-keto-3-deoxymanno-octulonic acid synthetase: convergent evolution of a sugar-activating enzyme with DNA/RNA polymerases.
J Biol Chem
; 284(51): 35514-23, 2009 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-19815542
17.
Evaluation of new thiazolide/thiadiazolide derivatives reveals nitro group-independent efficacy against in vitro development of Cryptosporidium parvum.
Antimicrob Agents Chemother
; 54(3): 1315-8, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20047919
18.
High-performance liquid chromatography/mass spectrometric and proton nuclear magnetic resonance spectroscopic studies of the transacylation and hydrolysis of the acyl glucuronides of a series of phenylacetic acids in buffer and human plasma.
Rapid Commun Mass Spectrom
; 24(20): 3043-51, 2010 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-20872637
19.
Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols.
Org Biomol Chem
; 8(9): 2068-77, 2010 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-20401383
20.
Acyl glucuronide reactivity in perspective.
Drug Discov Today
; 25(9): 1639-1650, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32681884