RESUMO
Cannabis is widely smoked in Europe and its increasing use is becoming a major public health problem. Adulterating cannabis with glass beads or sand is a new trick used by dealers to increase the weight and boost profits. These recent practices are not without danger. We report two cases of respiratory symptoms related to the use of this kind of adulterated cannabis. The first case is a 33 year-old patient admitted for an acute inhalation pneumonitis secondary to smoking cannabis adulterated with grit sand. The CT scan showed patchy ground-glass opacities, mainly in the upper lobes. A broncho-alveolar lavage, examined under polarized light, revealed birefringent intracellular particles, identified as silica, in alveolar macrophages. Spontaneously clinical and radiological improvements were observed after stopping the use of contaminated cannabis. The second patient, who smoked cannabis mixed with glass beads, described epistaxis, mouth ulcers, sore throats and cough. CT scan and BAL were normal. Adulteration of cannabis with microscopic glass beads, alone or mixed with sand, is a recent and widespread practice in Europe. These anecdotal reports prompted the French Department of Health to advise cannabis smokers of the harmfulness of these contaminants.
Assuntos
Cannabis/efeitos adversos , Contaminação de Medicamentos , Inalação , Pneumonia/induzido quimicamente , Pneumonia/diagnóstico por imagem , Adulto , Tosse/induzido quimicamente , Epistaxe/induzido quimicamente , França , Humanos , Masculino , Úlceras Orais/induzido quimicamente , Faringite/induzido quimicamente , Pneumonia/diagnóstico , RadiografiaAssuntos
Antimaláricos/efeitos adversos , Toxidermias/patologia , Proguanil/efeitos adversos , Eosinofilia Pulmonar/patologia , Adulto , Antimaláricos/uso terapêutico , Líquido da Lavagem Broncoalveolar , Toxidermias/etiologia , Exantema/etiologia , Exantema/patologia , Feminino , Humanos , Malária/tratamento farmacológico , Testes do Emplastro , Proguanil/uso terapêutico , Eosinofilia Pulmonar/etiologia , Índice de Gravidade de Doença , Resultado do TratamentoRESUMO
INTRODUCTION: Lung cancer continues to have a poor prognosis despite some therapeutic advances. BACKGROUND: The last fifteen years has seen a dramatic increase in the incidence of lung cancer in women and an increased proportion of adenocarcinomas in both sexes. A study of overall survival as a function of gender and other prognostic factors has been established using the cohort of patients from the study KBP-2000-CPHG. METHODS: KBP-2000-CPHG is an epidemiological study carried out throughout the year 2000 looking at histologically confirmed primary lung cancers managed in general hospitals. 5,667 patients have been included. The study of survival looks at 2 and 5-year outcomes. The date and cause of death are recorded for each patient. In the absence of these data the date of the last contact is noted. If this is less than 4 months the patient is considered to be alive. If more than four months have elapsed a graduated strategy for establishing vital status is pursued which involves reviewing records from various different sources. RESULTS AWAITED: A preliminary review of the data was undertaken between September 2004 and March 2005 which obtained data on 5 567 patients. The analysis of survival according to sex and other forecast prognostic factors is underway.
Assuntos
Neoplasias Pulmonares/mortalidade , Adenocarcinoma/mortalidade , Adenocarcinoma/patologia , Adulto , Distribuição por Idade , Idoso , Carcinoma de Células Grandes/mortalidade , Carcinoma de Células Grandes/patologia , Carcinoma Pulmonar de Células não Pequenas/mortalidade , Carcinoma Pulmonar de Células não Pequenas/patologia , Carcinoma de Células Pequenas/mortalidade , Carcinoma de Células Pequenas/patologia , Carcinoma de Células Escamosas/mortalidade , Carcinoma de Células Escamosas/patologia , Causas de Morte , Estudos de Coortes , Feminino , Seguimentos , França/epidemiologia , Hospitais Gerais/estatística & dados numéricos , Humanos , Neoplasias Pulmonares/patologia , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Prognóstico , Distribuição por Sexo , Fumar/efeitos adversos , Fumar/epidemiologia , Fatores Socioeconômicos , Análise de SobrevidaRESUMO
Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the accumulation of lipoproteinaceous material within the alveoli. Though many studies addressed biochemical data in bronchoalveolar lavage (BAL) effluent, poor attention was payed to cell profile in PAP. We report the case of a 40 year old woman, presenting with progressive respiratory failure and bilateral pulmonary infiltrates. BAL and transbronchial biopsy confirmed PAP. Therapeutic whole lung lavage led to full clinical and radiological remission. Sequential BAL follow-up was started over a 4-year period. As previously reported, lymphocytes were increased prior to whole lung lavage. This pattern subsequently remained, whereas recurrence or superinfections did not occur. The mechanism of this disorder is unclear and deserves further investigation.
Assuntos
Líquido da Lavagem Broncoalveolar/citologia , Linfocitose/patologia , Proteinose Alveolar Pulmonar/patologia , Adulto , Feminino , Seguimentos , Humanos , Pulmão , Proteinose Alveolar Pulmonar/terapia , Irrigação TerapêuticaRESUMO
The authors present the case of three young female patients, of the same family, with all quickly fatal Primary Pulmonary Hypertension (PPH). Their clinical signs and paraclinical investigations were suggestive of a PPH and excluded all others causes of Pulmonary Hypertension. These observations recall the possible familial cases of this rare and very severe disease. It emphasizes as well the possible revelation of the disease during or after a pregnancy. So the members of this family, essentially first the young women who wish to have children, need a medical detection.
Assuntos
Hipertensão Pulmonar/genética , Complicações Cardiovasculares na Gravidez , Adulto , Feminino , Humanos , Hipertensão Pulmonar/diagnóstico , Hipertensão Pulmonar/mortalidade , Recém-Nascido , Linhagem , Gravidez , Radiografia TorácicaRESUMO
INTRODUCTION: Necrotising sarcoid granulomatosis is a rare clinical entity, characterised by the development of nodular pulmonary opacities, the diagnosis if which is based on the identification of characteristic pathological lesions. CASE REPORT: A 44-years-old male smoker presented with cough and fever. With the exception of a few basal crepitations clinical examination was normal. The chest x-ray showed multiple areas of alveolar consolidation scattered throughout both lung fields, some of which were cavitated. The thoracic CT scan confirmed the presence of cavitating nodules and hilar and mediastinal lymphadenopathy. Samples for mycobacteria were negative. A search for anti-neutrophil cytoplasmic antibodies was negative. Fibreoptic bronchoscopy was normal but transbronchial biopsies revealed giant cells. Lung biopsies taken by video thoracoscopy showed non-caseating granulomata with areas of fibrinoid necrosis and perivascular infiltration with lymphocytes, histology characteristic of necrotising sarcoid granulomatosis. Resolution occurred without treatment. The parenchymal lesions regressed leaving residual cavities. Four years later, following an episode of haemoptysis, the patient was found to have a squamous cell carcinoma (T1N0M0) and aspergillomas in the pulmonary cavities. CONCLUSIONS: Our observation demonstrates that the cavities of necrotising sarcoid granulomatosis may be complicated by aspergillomas.
Assuntos
Aspergilose/etiologia , Granuloma/complicações , Granuloma/patologia , Pneumopatias Fúngicas/etiologia , Pneumopatias/complicações , Pneumopatias/patologia , Pulmão/patologia , Adulto , Aspergilose/patologia , Biópsia , Carcinoma Pulmonar de Células não Pequenas/diagnóstico , Granuloma/diagnóstico , Humanos , Pneumopatias/diagnóstico , Pneumopatias Fúngicas/patologia , Neoplasias Pulmonares/diagnóstico , Masculino , NecroseRESUMO
The first step in the diagnosis of a pleural effusion is to determine the exudative or transudative nature of the fluid. The purpose of this work was to compare different biological criteria commonly used in clinical practice. Among 118 pleural effusion fluids studied, 24.6% were exudates and 75.6% were transudates. The different parameters studied were Light criteria, Costa criteria, protein content, cholesterol content, and lactate dehydrogenase activity in the pleural fluid. The results showed that the Light criteria enabled classing all the fluids as exudates or transudates. We were also able to demonstrate that simple assay of lactate dehydrogenase activity in the pleural fluid gave comparable results, avoiding the need for further blood samples.
Assuntos
Derrame Pleural/etiologia , Idoso , Idoso de 80 Anos ou mais , Proteínas Sanguíneas/metabolismo , Colesterol/metabolismo , Diagnóstico Diferencial , Exsudatos e Transudatos/fisiologia , Feminino , Humanos , L-Lactato Desidrogenase/metabolismo , Masculino , Pessoa de Meia-Idade , Derrame Pleural/fisiopatologia , Derrame Pleural Maligno/diagnóstico , Derrame Pleural Maligno/etiologia , Derrame Pleural Maligno/fisiopatologiaRESUMO
The cell populations in the alveoli are exposed to the environment and react differently to each type of challenge (mineral particles, toxic gases, infections, antigenic substances. . .). Amongst the best studied of these irritant factors is tobacco smoke which in the long term leads to a number of changes both in the distribution of alveolar cells and also their function and morphology. Amongst acute and sub-acute pathogens, bacterial infections produce a rapid poly-morpho-nuclear neutrophilia and then a lymphocytosis; oxygen and oxidising agents in general lead to a neutrophilia which amplifies the pulmonary parenchymal changes related to the release of toxic metabolites of oxygen. The inhalation of antigenic substances also disturbs the behaviour of alveolar cells: activation of macrophages in the presence of allergy in those sensitized to IgE and immediate attraction of neutrophils preceding a T lymphocyte alveolitis in hypersensitivity pneumonia. It is possible to categorise several patterns of reaction in intra-pulmonary cells when challenged by some insult, a direct cytotoxic action, the accumulation of inflammatory cells and immunological competence corresponding to the concept of "a neutrophil alveolitis" or a "T cell alveolitis" with the development of emphysematous lesions. An understanding of the cellular make-up present in the alveoli when reacting to an external pathogen enables a better approach to the pathophysiological mechanisms in question.
Assuntos
Alveolite Alérgica Extrínseca/fisiopatologia , Macrófagos/fisiologia , Poluentes Atmosféricos/efeitos adversos , Animais , Humanos , Óxidos/efeitos adversos , Oxigênio/efeitos adversos , Alvéolos Pulmonares/citologia , Hipersensibilidade Respiratória/fisiopatologia , Infecções Respiratórias/fisiopatologia , FumarRESUMO
In 19 patients suffering from lobar pneumonia and treated with antibiotics, bronchoalveolar lavages were performed in attempt to follow the course of the biological disorders caused by the pulmonary bacterial infection. The cytologic study of the fluid harvested from 14 patients with normal immune reactivity showed, firstly, a polymorphonuclear leucocytosis and, after about ten days, a lymphocytosis, reaching 30 to 70% of the alveolar cell population. These cell disorders existed only in the lobe affected by the pneumonia process. In five alcoholics (one of them also splenectomized), the polymorphonuclear leucocytosis lasted 15 to 25 days and the lymphocytosis was delayed and moderate. We also searched for the pneumococcal antigen by counter-current immunoelectrophoresis using a polyvalent antiserum. We found it in 13 patients, 7 with a positive hemoculture for pneumococcus and 6 negatives. Clearance of this antigen was slow, non modified by alcoholism. We found this antigen in two patients later, between the 90th and 110th days, in the lavage fluid concentrated fifty times. The quantitative and qualitative study of the immunoglobulins revealed considerable individual variations, owing to the variable intensity of the local inflammation phenomenons and to the technical difficulties of their dosage in the lavage fluid.
Assuntos
Pneumonia Pneumocócica/imunologia , Alvéolos Pulmonares/citologia , Adolescente , Adulto , Idoso , Antígenos de Bactérias/isolamento & purificação , Líquidos Corporais/citologia , Contraimunoeletroforese , Feminino , Humanos , Imunoglobulinas/análise , Leucocitose , Masculino , Pessoa de Meia-Idade , Neutrófilos/imunologia , Streptococcus pneumoniae/imunologiaRESUMO
Among 189 patients treated for massive or repeated hemoptysis by transcatheter techniques between 1973 and 1983, a prospective study was attempted between 1979 and 1983 (72 patients) to search for bleeding of pulmonary arterial origin. Among these 72 patients, six were treated by surgical (one) or angiographic (five) occlusion of segmental pulmonary arteries. Pulmonary erosive pseudoaneurysms were seen in five cases (one with intracavitary aspergilloma, two with cavitary tuberculosis, and two with pyogenic abscesses). Among these six cases, one patient died from massive hemoptysis, one from unknown causes, and four are still alive. They are compared with five other patients who died from massive hemoptysis among 117 patients treated only by embolization of their systemic arteries between 1973 and 1979 (one with cavitary tuberculosis, two with intracavitary aspergillomas, one with an abscess of the lung, and one with a necrotic hilar cancer). A pulmonary arterial source of bleeding should be considered in addition to systemic arterial sources in the setting of destructive lung disease.