Detalhe da pesquisa
1.
Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.
Biochemistry
; 57(47): 6604-6614, 2018 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30365304
2.
Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis.
J Pharmacol Exp Ther
; 360(1): 1-13, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27754931
3.
Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors.
Bioorg Med Chem Lett
; 27(3): 413-419, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28041831
4.
Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors.
Bioorg Med Chem Lett
; 26(12): 2855-2860, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27146606
5.
Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.
Mol Pharmacol
; 88(6): 982-92, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26371182
6.
Structural basis of the substrate specificity of bifunctional isocitrate dehydrogenase kinase/phosphatase.
Biochemistry
; 50(38): 8103-6, 2011 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21870819
7.
Structural and biochemical basis for misfolded RNA recognition by the Ro autoantigen.
Nat Struct Mol Biol
; 13(11): 1002-9, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17041599
8.
Improved homology modeling of the human & rat EP4 prostanoid receptors.
BMC Mol Cell Biol
; 20(1): 37, 2019 08 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31455205
9.
Difluoromethylene at the γ-Lactam α-Position Improves 11-Deoxy-8-aza-PGE1 Series EP4 Receptor Binding and Activity: 11-Deoxy-10,10-difluoro-8-aza-PGE1 Analog (KMN-159) as a Potent EP4 Agonist.
J Med Chem
; 62(9): 4731-4741, 2019 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30964292
10.
Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.
ChemMedChem
; 14(16): 1560-1572, 2019 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31283109
11.
Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.
Sci Transl Med
; 10(431)2018 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29515000
12.
Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity.
Cell
; 121(4): 529-539, 2005 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15907467
13.
The crystal structure and mechanism of 1-L-myo-inositol- 1-phosphate synthase.
J Biol Chem
; 277(11): 9484-91, 2002 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-11779862