1.
Chem Commun (Camb)
; 55(86): 12932-12935, 2019 Oct 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31599282
RESUMO
Here, we report the development of novel PET radiotracer ([11C]CW22) of BET proteins. In vivo imaging results in rodents and nonhuman primates (NHP) demonstrate that [11C]CW22 has excellent brain uptake, good specificity, good selectivity, suitable metabolism, appropriate kinetics and distribution in the brain. Our studies demonstrated that [11C]CW22 exhibits ideal properties as a PET imaging probe of BET proteins for further validation.