Detalhe da pesquisa
1.
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.
Nat Neurosci
; 3(6): 587-92, 2000 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-10816315
2.
Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives.
J Med Chem
; 35(2): 295-305, 1992 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-1732546
3.
Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors.
J Med Chem
; 36(11): 1529-38, 1993 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-8496922
4.
Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors.
J Med Chem
; 38(10): 1799-810, 1995 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-7752204
5.
Synthesis and serotonergic activity of 3-[2-(pyrrolidin-1-yl)ethyl]indoles: potent agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B receptor.
J Med Chem
; 42(4): 677-90, 1999 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-10052975
6.
Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.
J Med Chem
; 33(10): 2690-7, 1990 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-2213823
7.
3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents.
J Med Chem
; 42(4): 691-705, 1999 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-10052976
8.
L-694,247: a potent 5-HT1D receptor agonist.
Br J Pharmacol
; 110(3): 1196-200, 1993 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-8298808
9.
L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3 muscarinic receptors.
Br J Pharmacol
; 107(2): 494-501, 1992 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-1422595
10.
MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans.
J Psychopharmacol
; 25(3): 314-28, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20147571
11.
Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective partial agonist.
J Psychopharmacol
; 25(3): 329-44, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20156926
12.
3-[2-(Pyrrolidin-1-yl)ethyl]indoles and 3-[3-(piperidin-1-yl)propyl]indoles: agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B subtype.
J Med Chem
; 40(22): 3497-500, 1997 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-9357514
13.
Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents.
J Med Chem
; 40(22): 3501-3, 1997 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-9357515
14.
Approaches to rational drug development in Alzheimer's disease.
Drug Des Discov
; 9(3-4): 251-9, 1993.
Artigo
em Inglês
| MEDLINE | ID: mdl-8400006