Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

A multivalent mRNA monkeypox virus vaccine (BNT166) protects mice and macaques from orthopoxvirus disease.

Zuiani, Adam; Dulberger, Charles L; De Silva, Nilushi S; Marquette, Meghan; Lu, Yu-Jung; Palowitch, Gavin M; Dokic, Anja; Sanchez-Velazquez, Ricardo; Schlatterer, Katja; Sarkar, Sanjay; Kar, Swagata; Chawla, Bhavna; Galeev, Alibek; Lindemann, Claudia; Rothenberg, Daniel A; Diao, Huitian; Walls, Alexandra C; Addona, Theresa A; Mensa, Federico; Vogel, Annette B; Stuart, Lynda M; van der Most, Robbert; Srouji, John R; Türeci, Özlem; Gaynor, Richard B; Sahin, Ugur; Poran, Asaf.

Cell ; 187(6): 1363-1373.e12, 2024 Mar 14.

Artigo em Inglês | MEDLINE | ID: mdl-38366591

2.

TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.

Rathinam, Vijay A K; Vanaja, Sivapriya Kailasan; Waggoner, Lisa; Sokolovska, Anna; Becker, Christine; Stuart, Lynda M; Leong, John M; Fitzgerald, Katherine A.

Cell ; 150(3): 606-19, 2012 Aug 03.

Artigo em Inglês | MEDLINE | ID: mdl-22819539

3.

Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.

Sokolovska, Anna; Becker, Christine E; Ip, W K Eddie; Rathinam, Vijay A K; Brudner, Matthew; Paquette, Nicholas; Tanne, Antoine; Vanaja, Sivapriya K; Moore, Kathryn J; Fitzgerald, Katherine A; Lacy-Hulbert, Adam; Stuart, Lynda M.

Nat Immunol ; 14(6): 543-53, 2013 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-23644505

4.

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.

Sheedy, Frederick J; Grebe, Alena; Rayner, Katey J; Kalantari, Parisa; Ramkhelawon, Bhama; Carpenter, Susan B; Becker, Christine E; Ediriweera, Hasini N; Mullick, Adam E; Golenbock, Douglas T; Stuart, Lynda M; Latz, Eicke; Fitzgerald, Katherine A; Moore, Kathryn J.

Nat Immunol ; 14(8): 812-20, 2013 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-23812099

5.

The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques.

van Gils, Janine M; Derby, Merran C; Fernandes, Luciana R; Ramkhelawon, Bhama; Ray, Tathagat D; Rayner, Katey J; Parathath, Sajesh; Distel, Emilie; Feig, Jessica L; Alvarez-Leite, Jacqueline I; Rayner, Alistair J; McDonald, Thomas O; O'Brien, Kevin D; Stuart, Lynda M; Fisher, Edward A; Lacy-Hulbert, Adam; Moore, Kathryn J.

Nat Immunol ; 13(2): 136-43, 2012 Jan 08.

Artigo em Inglês | MEDLINE | ID: mdl-22231519

6.

Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.

Visvikis, Orane; Ihuegbu, Nnamdi; Labed, Sid A; Luhachack, Lyly G; Alves, Anna-Maria F; Wollenberg, Amanda C; Stuart, Lynda M; Stormo, Gary D; Irazoqui, Javier E.

Immunity ; 40(6): 896-909, 2014 Jun 19.

Artigo em Inglês | MEDLINE | ID: mdl-24882217

7.

De-Mst-ifying microbicidal killing.

Stuart, Lynda M; Lacy-Hulbert, Adam.

Nat Immunol ; 16(11): 1107-8, 2015 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-26482969

8.

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

Stewart, Cameron R; Stuart, Lynda M; Wilkinson, Kim; van Gils, Janine M; Deng, Jiusheng; Halle, Annett; Rayner, Katey J; Boyer, Laurent; Zhong, Ruiqin; Frazier, William A; Lacy-Hulbert, Adam; El Khoury, Joseph; Golenbock, Douglas T; Moore, Kathryn J.

Nat Immunol ; 11(2): 155-61, 2010 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-20037584

9.

B Cell αv Integrins Regulate TLR-Driven Autoimmunity.

Acharya, Mridu; Raso, Fiona; Sagadiev, Sara; Gilbertson, Emily; Kadavy, Lauren; Li, Quan Z; Yan, Mei; Stuart, Lynda M; Hamerman, Jessica A; Lacy-Hulbert, Adam.

J Immunol ; 205(7): 1810-1818, 2020 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-32859730

10.

Penetration resistance: PKR's other talent.

Lacy-Hulbert, Adam; Stuart, Lynda M.

Immunity ; 36(5): 695-6, 2012 May 25.

Artigo em Inglês | MEDLINE | ID: mdl-22633454

11.

Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway.

Boyer, Laurent; Magoc, Lorin; Dejardin, Stephanie; Cappillino, Michael; Paquette, Nicholas; Hinault, Charlotte; Charriere, Guillaume M; Ip, W K Eddie; Fracchia, Shannon; Hennessy, Elizabeth; Erturk-Hasdemir, Deniz; Reichhart, Jean-Marc; Silverman, Neal; Lacy-Hulbert, Adam; Stuart, Lynda M.

Immunity ; 35(4): 536-49, 2011 Oct 28.

Artigo em Inglês | MEDLINE | ID: mdl-22018470

12.

In Gratitude for mRNA Vaccines.

Stuart, Lynda M.

N Engl J Med ; 385(15): 1436-1438, 2021 Oct 07.

Artigo em Inglês | MEDLINE | ID: mdl-34569728

13.

Tuberculosis vaccines: barriers and prospects on the quest for a transformative tool.

Karp, Christopher L; Wilson, Christopher B; Stuart, Lynda M.

Immunol Rev ; 264(1): 363-81, 2015 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-25703572

14.

ß8 Integrin Expression and Activation of TGF-ß by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage.

Boucard-Jourdin, Mathilde; Kugler, David; Endale Ahanda, Marie-Laure; This, Sébastien; De Calisto, Jaime; Zhang, Ailiang; Mora, J Rodrigo; Stuart, Lynda M; Savill, John; Lacy-Hulbert, Adam; Paidassi, Helena.

J Immunol ; 197(5): 1968-78, 2016 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-27481847

15.

Dectin-1-dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages.

Tam, Jenny M; Mansour, Michael K; Khan, Nida S; Seward, Michael; Puranam, Sravanthi; Tanne, Antoine; Sokolovska, Anna; Becker, Christine E; Acharya, Mridu; Baird, Michelle A; Choi, Augustine M K; Davidson, Michael W; Segal, Brahm H; Lacy-Hulbert, Adam; Stuart, Lynda M; Xavier, Ramnik J; Vyas, Jatin M.

J Infect Dis ; 210(11): 1844-54, 2014 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-24842831

16.

Dectin-1 activation controls maturation of ß-1,3-glucan-containing phagosomes.

Mansour, Michael K; Tam, Jenny M; Khan, Nida S; Seward, Michael; Davids, Peter J; Puranam, Sravanthi; Sokolovska, Anna; Sykes, David B; Dagher, Zeina; Becker, Christine; Tanne, Antoine; Reedy, Jennifer L; Stuart, Lynda M; Vyas, Jatin M.

J Biol Chem ; 288(22): 16043-54, 2013 May 31.

Artigo em Inglês | MEDLINE | ID: mdl-23609446

17.

EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways.

Luhachack, Lyly G; Visvikis, Orane; Wollenberg, Amanda C; Lacy-Hulbert, Adam; Stuart, Lynda M; Irazoqui, Javier E.

PLoS Pathog ; 8(7): e1002798, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-22792069

18.

LITAF protects against pore-forming protein-induced cell death by promoting membrane repair.

Stefani, Caroline; Bruchez, Anna M; Rosasco, Mario G; Yoshida, Anna E; Fasano, Kayla J; Levan, Paula F; Lorant, Alina; Hubbard, Nicholas W; Oberst, Andrew; Stuart, Lynda M; Lacy-Hulbert, Adam.

Sci Immunol ; 9(91): eabq6541, 2024 Jan 05.

Artigo em Inglês | MEDLINE | ID: mdl-38181093

19.

Apoptotic cells can deliver chemotherapeutics to engulfing macrophages and suppress inflammatory cytokine production.

Perez, Beatriz; Paquette, Nicholas; Païdassi, Helena; Zhai, Bo; White, Kristin; Skvirsky, Rachel; Lacy-Hulbert, Adam; Stuart, Lynda M.

J Biol Chem ; 287(19): 16029-36, 2012 May 04.

Artigo em Inglês | MEDLINE | ID: mdl-22433861

20.

Mannose-binding lectin and innate immunity.

Ip, W K Eddie; Takahashi, Kazue; Ezekowitz, R Alan; Stuart, Lynda M.

Immunol Rev ; 230(1): 9-21, 2009 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-19594626

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