Detalhe da pesquisa
1.
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain.
Acta Pharmacol Sin
; 43(8): 2147-2155, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34907358
2.
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma.
Acta Pharmacol Sin
; 43(4): 1091-1099, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-34341512
3.
Curcusone D, a novel ubiquitin-proteasome pathway inhibitor via ROS-induced DUB inhibition, is synergistic with bortezomib against multiple myeloma cell growth.
Biochim Biophys Acta
; 1840(6): 2004-13, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24534329
4.
Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice.
Toxicol Appl Pharmacol
; 273(2): 325-34, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24055643
5.
Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.
EMBO Rep
; 12(3): 238-43, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21331099
6.
Synthesis and biological evaluation of piperamide analogues as HDAC inhibitors.
Bioorg Med Chem Lett
; 21(16): 4844-6, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21745740
7.
Synthesis and in Vitro and in Vivo Biological Evaluation of Tissue-Specific Bisthiazole Histone Deacetylase (HDAC) Inhibitors.
J Med Chem
; 63(2): 804-815, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31855601
8.
Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo.
J Med Chem
; 63(8): 4388-4407, 2020 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32216342
9.
Novel spirocyclic tranylcypromine derivatives as lysine-specific demethylase 1 (LSD1) inhibitors.
RSC Adv
; 8(3): 1666-1676, 2018 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35540911
10.
Tying up tranylcypromine: Novel selective histone lysine specific demethylase 1 (LSD1) inhibitors.
Eur J Med Chem
; 141: 101-112, 2017 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29031059
11.
Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy.
Eur J Med Chem
; 112: 81-90, 2016 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26890114
12.
Potent and orally efficacious bisthiazole-based histone deacetylase inhibitors.
ACS Med Chem Lett
; 5(6): 628-33, 2014 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24944733
13.
Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators.
ACS Med Chem Lett
; 4(5): 475-80, 2013 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900695
14.
Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells.
J Biol Chem
; 283(23): 16051-60, 2008 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-18321858