Detalhe da pesquisa
1.
Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain.
Bioorg Med Chem Lett
; 51: 128354, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34506932
2.
Development of WEE2 kinase inhibitors as novel non-hormonal female contraceptives that target meiosis.
Biol Reprod
; 103(2): 368-377, 2020 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32667031
3.
Development of potent and selective ULK1/2 inhibitors based on 7-azaindole scaffold with favorable in vivo properties.
Eur J Med Chem
; 266: 116101, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38232465
4.
Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target.
ACS Chem Biol
; 18(2): 251-264, 2023 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36630201
5.
Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice.
J Med Chem
; 66(3): 1928-1940, 2023 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36701569
6.
Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding.
Nat Commun
; 14(1): 3213, 2023 06 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37270540
7.
Structural Insight into BLM Recognition by TopBP1.
Structure
; 25(10): 1582-1588.e3, 2017 10 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28919440
8.
Antitumor Activity of Lankacidin Group Antibiotics Is Due to Microtubule Stabilization via a Paclitaxel-like Mechanism.
J Med Chem
; 59(20): 9532-9540, 2016 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27718573
9.
Peptide library approach to uncover phosphomimetic inhibitors of the BRCA1 C-terminal domain.
ACS Chem Biol
; 10(5): 1198-208, 2015 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25654734
10.
Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control.
Structure
; 21(8): 1450-9, 2013 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23891287