Detalhe da pesquisa
1.
Allele-Specific Silencing Ameliorates Restrictive Cardiomyopathy Attributable to a Human Myosin Regulatory Light Chain Mutation.
Circulation
; 140(9): 765-778, 2019 08 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31315475
2.
Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human ß-cardiac myosin.
J Exp Biol
; 219(Pt 2): 161-7, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26792326
3.
Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human ß-cardiac myosin motor function.
Proc Natl Acad Sci U S A
; 110(31): 12607-12, 2013 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-23798412
4.
Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin.
BMC Med Genet
; 16: 97, 2015 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-26498512
5.
Regional Variation in Cardiovascular Genes Enables a Tractable Genome Editing Strategy.
Circ Genom Precis Med
; 17(2): e004370, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38506054
6.
Epistasis regulates genetic control of cardiac hypertrophy.
Res Sq
; 2023 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38045390
7.
Epistasis regulates genetic control of cardiac hypertrophy.
medRxiv
; 2023 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37987017
8.
Deconvoluting complex correlates of COVID-19 severity with a multi-omic pandemic tracking strategy.
Nat Commun
; 13(1): 5107, 2022 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36042219
9.
Mono- and Biallelic Protein-Truncating Variants in Alpha-Actinin 2 Cause Cardiomyopathy Through Distinct Mechanisms.
Circ Genom Precis Med
; 14(6): e003419, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34802252
10.
High-throughput SARS-CoV-2 and host genome sequencing from single nasopharyngeal swabs.
medRxiv
; 2020 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32766602
11.
Genetic variation drives seasonal onset of hibernation in the 13-lined ground squirrel.
Commun Biol
; 2: 478, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31886416
12.
Dictyostelium myosin bipolar thick filament formation: importance of charge and specific domains of the myosin rod.
PLoS Biol
; 2(11): e356, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15492777
13.
Biophysical properties of human ß-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy.
Sci Adv
; 3(2): e1601959, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-28246639
14.
The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations.
Nat Struct Mol Biol
; 24(6): 525-533, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28481356
15.
Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector.
Cell Rep
; 11(6): 910-920, 2015 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25937279
16.
Contractility parameters of human ß-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function.
Sci Adv
; 1(9): e1500511, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26601291
17.
Harmonic force spectroscopy measures load-dependent kinetics of individual human ß-cardiac myosin molecules.
Nat Commun
; 6: 7931, 2015 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26239258
18.
Observation of correlated X-ray scattering at atomic resolution.
Philos Trans R Soc Lond B Biol Sci
; 369(1647): 20130315, 2014 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-24914148
19.
Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human ß-cardiac myosin.
PLoS One
; 8(12): e83403, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24367593
20.
EPR spectra and molecular dynamics agree that the nucleotide pocket of myosin V is closed and that it opens on binding actin.
J Mol Biol
; 411(1): 16-26, 2011 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-21640122