Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Mutational profile of the regenerative process and de novo genome assembly of the planarian Schmidtea polychroa.

Póti, Ádám; Szüts, Dávid; Vermezovic, Jelena.

Nucleic Acids Res ; 52(4): 1779-1792, 2024 Feb 28.

Artigo em Inglês | MEDLINE | ID: mdl-38180823

2.

Epistasis, aneuploidy, and functional mutations underlie evolution of resistance to induced microtubule depolymerization.

Pavani, Mattia; Bonaiuti, Paolo; Chiroli, Elena; Gross, Fridolin; Natali, Federica; Macaluso, Francesca; Póti, Ádám; Pasqualato, Sebastiano; Farkas, Zoltán; Pompei, Simone; Cosentino Lagomarsino, Marco; Rancati, Giulia; Szüts, Dávid; Ciliberto, Andrea.

EMBO J ; 40(22): e108225, 2021 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-34605051

3.

DNA mismatch repair protects the genome from oxygen-induced replicative mutagenesis.

Lózsa, Rita; Németh, Eszter; Gervai, Judit Z; Márkus, Bence G; Kollarics, Sándor; Gyüre, Zsolt; Tóth, Judit; Simon, Ferenc; Szüts, Dávid.

Nucleic Acids Res ; 51(20): 11040-11055, 2023 11 10.

Artigo em Inglês | MEDLINE | ID: mdl-37791890

4.

Characterisation of the spectrum and genetic dependence of collateral mutations induced by translesion DNA synthesis.

Póti, Ádám; Szikriszt, Bernadett; Gervai, Judit Zsuzsanna; Chen, Dan; Szüts, Dávid.

PLoS Genet ; 18(2): e1010051, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-35130276

5.

BRCA1/Trp53 heterozygosity and replication stress drive esophageal cancer development in a mouse model.

He, Ye; Rivera, Joshua; Diossy, Miklos; Duan, Haohui; Bowman-Colin, Christian; Reed, Rachel; Jennings, Rebecca; Novak, Jesse; Tran, Stevenson V; Cohen, Elizabeth F; Szuts, David; Giobbie-Hurder, Anita; Bronson, Roderick T; Bass, Adam J; Signoretti, Sabina; Szallasi, Zoltan; Livingston, David M; Pathania, Shailja.

Proc Natl Acad Sci U S A ; 118(41)2021 10 12.

Artigo em Inglês | MEDLINE | ID: mdl-34607954

6.

Potential Association of Cytochrome P450 Copy Number Alteration in Tumour with Chemotherapy Resistance in Lung Adenocarcinoma Patients.

Incze, Evelyn; Mangó, Katalin; Fekete, Ferenc; Kiss, Ádám Ferenc; Póti, Ádám; Harkó, Tünde; Moldvay, Judit; Szüts, Dávid; Monostory, Katalin.

Int J Mol Sci ; 24(17)2023 Aug 29.

Artigo em Inglês | MEDLINE | ID: mdl-37686184

7.

A comparative analysis of the mutagenicity of platinum-containing chemotherapeutic agents reveals direct and indirect mutagenic mechanisms.

Szikriszt, Bernadett; Póti, Ádám; Németh, Eszter; Kanu, Nnennaya; Swanton, Charles; Szüts, Dávid.

Mutagenesis ; 36(1): 75-86, 2021 04 28.

Artigo em Inglês | MEDLINE | ID: mdl-33502495

8.

Establishment and Characterization of a Brca1^-/-, p53^-/- Mouse Mammary Tumor Cell Line.

Hámori, Lilla; Kudlik, Gyöngyi; Szebényi, Kornélia; Kucsma, Nóra; Szeder, Bálint; Póti, Ádám; Uher, Ferenc; Várady, György; Szüts, Dávid; Tóvári, József; Füredi, András; Szakács, Gergely.

Int J Mol Sci ; 21(4)2020 Feb 11.

Artigo em Inglês | MEDLINE | ID: mdl-32053991

9.

The genomic imprint of cancer therapies helps timing the formation of metastases.

Németh, Eszter; Krzystanek, Marcin; Reiniger, Lilla; Ribli, Dezso; Pipek, Orsolya; Sztupinszki, Zsófia; Glasz, Tibor; Csabai, István; Moldvay, Judit; Szallasi, Zoltan; Szüts, Dávid.

Int J Cancer ; 145(3): 694-704, 2019 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-30694556

10.

Long-term treatment with the PARP inhibitor niraparib does not increase the mutation load in cell line models and tumour xenografts.

Póti, Ádám; Berta, Kinga; Xiao, Yonghong; Pipek, Orsolya; Klus, Gregory T; Ried, Thomas; Csabai, István; Wilcoxen, Keith; Mikule, Keith; Szallasi, Zoltan; Szüts, Dávid.

Br J Cancer ; 119(11): 1392-1400, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30425352

11.

The mutagenic consequences of defective DNA repair.

Németh, Eszter; Szüts, Dávid.

DNA Repair (Amst) ; 139: 103694, 2024 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-38788323

12.

Probing the biological consequences of a previously undescribed de novo mutation of ZMYND11 in a schizophrenia patient by CRISPR genome editing and induced pluripotent stem cell based in vitro disease-modeling.

Tordai, Csongor; Hathy, Edit; Gyergyák, Hella; Vincze, Katalin; Baradits, Máté; Koller, Júlia; Póti, Ádám; Jezsó, Bálint; Homolya, László; Molnár, Mária Judit; Nagy, László; Szüts, Dávid; Apáti, Ágota; Réthelyi, János M.

Schizophr Res ; 2024 Jan 29.

Artigo em Inglês | MEDLINE | ID: mdl-38290943

13.

Increased frequency of CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression without inducing homologous recombination deficiency.

Szallasi, Zoltan; Diossy, Miklos; Tisza, Viktoria; Li, Hua; Sahgal, Pranshu; Zhou, Jia; Sztupinszki, Zsofia; Young, Denise; Nuosome, Darryl; Kuo, Claire; Jiang, Jiji; Chen, Yongmei; Ebner, Reinhard; Sesterhenn, Isabell; Moncur, Joel; Chesnut, Gregory; Petrovics, Gyorgy; T Klus, Gregory; Valcz, Gábor; Nuzzo, Pier; Ribli, Dezso; Börcsök, Judit; Prósz, Aurél; Krzystanek, Marcin; Ried, Thomas; Szüts, Dávid; Rizwan, Kinza; Kaochar, Salma; Pathania, Shailja; D'Andrea, Alan; Csabai, István; Srivastava, Shib; Freedman, Matthew; Dobi, Albert; Spisak, Sandor.

Res Sq ; 2024 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-38645014

14.

Simultaneous disruption of two DNA polymerases, PolÎ· and PolÎ¶, in Avian DT40 cells unmasks the role of PolÎ· in cellular response to various DNA lesions.

Hirota, Kouji; Sonoda, Eiichiro; Kawamoto, Takuo; Motegi, Akira; Masutani, Chikahide; Hanaoka, Fumio; Szüts, Dávid; Iwai, Shigenori; Sale, Julian E; Lehmann, Alan; Takeda, Shunichi.

PLoS Genet ; 6(10)2010 Oct 07.

Artigo em Inglês | MEDLINE | ID: mdl-20949111

15.

Probing telomeric-like G4 structures with full or partial 2'-deoxy-5-hydroxyuridine substitutions.

Szeltner, Zoltán; Ferenc, Györgyi; Juhász, Tünde; Kupihár, Zoltán; Váradi, Zoltán; Szüts, Dávid; Kovács, Lajos.

Biochimie ; 214(Pt A): 33-44, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-36707016

16.

Spontaneous mutagenesis in human cells is controlled by REV1-Polymerase Î¶ and PRIMPOL.

Gyüre, Zsolt; Póti, Ádám; Németh, Eszter; Szikriszt, Bernadett; Lózsa, Rita; Krawczyk, Michal; Richardson, Andrea L; Szüts, Dávid.

Cell Rep ; 42(8): 112887, 2023 Aug 29.

Artigo em Inglês | MEDLINE | ID: mdl-37498746

17.

A fresh look at somatic mutations in cancer.

Szüts, Dávid.

Science ; 376(6591): 351-352, 2022 04 22.

Artigo em Inglês | MEDLINE | ID: mdl-35446665

18.

Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers.

DeWeerd, Rachel A; Németh, Eszter; Póti, Ádám; Petryk, Nataliya; Chen, Chun-Long; Hyrien, Olivier; Szüts, Dávid; Green, Abby M.

Cell Rep ; 38(12): 110555, 2022 03 22.

Artigo em Inglês | MEDLINE | ID: mdl-35320711

19.

BRCA1 deficiency specific base substitution mutagenesis is dependent on translesion synthesis and regulated by 53BP1.

Chen, Dan; Gervai, Judit Z; Póti, Ádám; Németh, Eszter; Szeltner, Zoltán; Szikriszt, Bernadett; Gyüre, Zsolt; Zámborszky, Judit; Ceccon, Marta; d'Adda di Fagagna, Fabrizio; Szallasi, Zoltan; Richardson, Andrea L; Szüts, Dávid.

Nat Commun ; 13(1): 226, 2022 01 11.

Artigo em Inglês | MEDLINE | ID: mdl-35017534

20.

Evaluation and modulation of DNA lesion bypass in an SV40 large T antigen-based in vitro replication system.

Szeltner, Zoltán; Póti, Ádám; Harami, Gábor M; Kovács, Mihály; Szüts, Dávid.

FEBS Open Bio ; 11(4): 1054-1075, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-33512058

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