RESUMO
Recent animal studies consistently confirm the involvement of brain-derived neurotrophic factor (BDNF) in the regulation of anxiety-related behaviours. The role of BDNF in human anxiety has been less investigated. The aim of our study was to examine the association between serum BDNF levels and panic/anxiety responses to cholecystokinin-tetrapeptide (CCK-4) challenge in healthy subjects. BDNF concentrations were detected in serum samples of 37 male and female volunteers before and 120 min after CCK-4 injection. The baseline levels of serum BDNF did not predict the occurrence of CCK-4-induced panic attacks or intensity of panic symptoms and did not significantly change 2 h after the challenge. BDNF serum concentrations 120 min after provocation did not differentiate panickers from non-panickers; however, the subjects reporting stronger anxiety response showed higher levels of BDNF than those with mild anxiety. The anxiety net increase on the Visual Analogue Scale, but not severity of panic symptoms, significantly and positively correlated with the change in BDNF concentration from baseline values. This is the first challenge study to demonstrate a possible impact of BDNF on human anxiety. Our findings suggest a general involvement of BDNF in the regulation of anxiety rather than a specific role of BDNF in disposition to panic attacks.
Assuntos
Ansiedade/induzido quimicamente , Ansiedade/metabolismo , Fator Neurotrófico Derivado do Encéfalo/sangue , Pânico/fisiologia , Tetragastrina/farmacologia , Adolescente , Adulto , Feminino , Humanos , Masculino , Pânico/efeitos dos fármacos , Transtorno de Pânico/induzido quimicamente , Transtorno de Pânico/metabolismoRESUMO
The purpose of this case-control genetic association study was to explore potential relationships between polymorphisms in the limbic system-associated membrane protein (LSAMP) gene and mood and anxiety disorders. A total of 21 single-nucleotide polymorphisms (SNPs) from the LSAMP gene were analyzed in 591 unrelated patients with the diagnoses of major depressive disorder (MDD) or panic disorder (PD) and in 384 healthy control subjects. The results showed a strong association between LSAMP SNPs and MDD, and a suggestive association between LSAMP SNPs and PD. This is the first evidence of a possible role of LSAMP gene in mood and anxiety disorders in humans.
Assuntos
Moléculas de Adesão Celular Neuronais/genética , Transtorno Depressivo Maior/genética , Transtorno de Pânico/genética , Adolescente , Adulto , Idoso , Alelos , Estudos de Casos e Controles , Moléculas de Adesão Celular Neuronais/sangue , Estônia , Feminino , Proteínas Ligadas por GPI/sangue , Proteínas Ligadas por GPI/genética , Predisposição Genética para Doença , Estudo de Associação Genômica Ampla , Genótipo , Haplótipos , Humanos , Masculino , Pessoa de Meia-Idade , Polimorfismo de Nucleotídeo Único , Fatores SexuaisRESUMO
The bone mineral density (BMD) and Z score in distal 1/3 radius were measured with dual energy X-ray absorptiometry (DEXA) in 185 hemodialysis (HD) patients, meanwhile serum parathyroid hormone (PTH), alkaline phosphatase (ALP) and hand X-rays were detected. Results showed that BMD in HD patients was significantly lower than that in control group(P < 0.05), and decreased with dialysis duration increasing. BMD in HD patients was negatively related with PTH, ALP and rate of subperiosteal erosions. By using Z score to diagnose hyperparathyroidism bone disease, receiver operating characteristic (ROC) curve was worked out. If Z score < or = -2.02, the sensitivity was 79.41% and specificity was 78.15%. In conclusion the measurement of BMD is a useful tool for the detection of hyperparathyroid bone disease.