Detalhe da pesquisa
1.
Synthesis and Evaluation of in Vivo Anti-hypothermic Effect of the N- and C-Terminus Modified Thyrotropin-Releasing Hormone Mimetic: [(4S,5S)-(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-[3-(thiazol-4-yl)-L-alanyl]-L-prolinamide.
Chem Pharm Bull (Tokyo)
; 69(4): 314-324, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33790077
2.
Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives.
Bioorg Med Chem Lett
; 30(24): 127636, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33132115
3.
Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compounds.
Bioorg Med Chem Lett
; 29(5): 688-693, 2019 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30728111
4.
Synthesis and evaluation of in vivo anti-hypothermic effect of all stereoisomers of the thyrotropin-releasing hormone mimetic: Rovatirelin Hydrate.
J Pept Sci
; 25(12): e3228, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31713944
5.
Influence of cognitive function on quality of life in anorexia nervosa patients.
Psychiatry Clin Neurosci
; 71(5): 328-335, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-27973723
6.
A phase 3 randomized controlled trial of a COVID-19 recombinant vaccine S-268019-b versus ChAdOx1 nCoV-19 in Japanese adults.
Sci Rep
; 14(1): 9830, 2024 04 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38684712
7.
A SARS-CoV-2 recombinant spike protein vaccine (S-268019-b) for COVID-19 prevention during the Omicron-dominant period: A phase 3, randomised, placebo-controlled clinical trial.
Vaccine
; 42(17): 3699-3709, 2024 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38734495
8.
Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists.
Bioorg Med Chem
; 21(7): 2045-55, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23395112
9.
Selective CB2 agonists with anti-pruritic activity: discovery of potent and orally available bicyclic 2-pyridones.
Bioorg Med Chem
; 21(11): 3154-63, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23623258
10.
Results from a preclinical study in rodents and a Phase 1/2, randomized, double-blind, placebo-controlled, parallel-group study of COVID-19 vaccine S-268019-a in Japanese adults.
Vaccine
; 41(11): 1834-1847, 2023 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36572603
11.
Psychiatric disorders in cancer patients at a university hospital in Japan: descriptive analysis of 765 psychiatric referrals.
Jpn J Clin Oncol
; 42(3): 183-8, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22259217
12.
Dissociative stupor mimicking consciousness disorder in an advanced lung cancer patient.
Jpn J Clin Oncol
; 42(6): 548-51, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22504782
13.
Psychological distress of the bereaved seeking medical counseling at a cancer center.
Jpn J Clin Oncol
; 42(6): 506-12, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22561513
14.
Psychiatric disorders in patients who lost family members to cancer and asked for medical help: descriptive analysis of outpatient services for bereaved families at Japanese cancer center hospital.
Jpn J Clin Oncol
; 41(3): 380-5, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21109510
15.
Drug-induced akathisia as a cause of distress in spouse caregivers of cancer patients.
Palliat Support Care
; 9(2): 209-12, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24468489
16.
Clinical Drug-Drug Interaction Studies to Evaluate the Effects of a P-Glycoprotein Inhibitor, CYP3A Inhibitors, and a CYP3A Inducer on the Pharmacokinetics of Naldemedine in Healthy Subjects.
Clin Drug Investig
; 40(6): 529-540, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-32323104
17.
Naldemedine in Japanese patients with opioid-induced constipation and chronic noncancer pain: open-label Phase III studies.
J Pain Res
; 12: 127-138, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613161
18.
Safety and efficacy of naldemedine in cancer patients with opioid-induced constipation: a pooled, subgroup analysis of two randomised controlled studies.
ESMO Open
; 4(4): e000527, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31423335
19.
Correction to Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1-{N-[(4S,5S)-(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)-l-alanyl}-(2R)-2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate).
ACS Omega
; 4(4): 6977-6978, 2019 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31459810
20.
Rational design and development of near-infrared-emitting firefly luciferins available in vivo.
Angew Chem Int Ed Engl
; 52(4): 1175-9, 2013 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23212783