1.
J Org Chem
; 78(17): 8847-52, 2013 Sep 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23895439
RESUMO
Azomethine imines can be accessed upon heating appropriate alkynylhydrazide precursors. This simple thermal hydroamination approach allows the formation of five- and six-membered dipoles in modest to excellent yields. The structure of the acyl group is important to minimize side reactions and allow the isolation of the azomethine imines by column chromatography.