Detalhe da pesquisa
1.
Tumor microenvironment and breast cancer survival: combined effects of breast fat, M2 macrophages and hyaluronan create a dismal prognosis.
Breast Cancer Res Treat
; 179(3): 565-575, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-31720917
2.
Peritumoral ADC values in breast cancer: region of interest selection, associations with hyaluronan intensity, and prognostic significance.
Eur Radiol
; 30(1): 38-46, 2020 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-31359124
3.
Extracellular ATP activates hyaluronan synthase 2 (HAS2) in epidermal keratinocytes via P2Y2, Ca2+ signaling, and MAPK pathways.
Biochem J
; 475(10): 1755-1772, 2018 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29626161
4.
Human Keratinocytes Respond to Extracellular UTP by Induction of Hyaluronan Synthase 2 Expression and Increased Hyaluronan Synthesis.
J Biol Chem
; 292(12): 4861-4872, 2017 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28188289
5.
UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression.
Cell Mol Life Sci
; 73(16): 3183-204, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26883802
6.
Interleukin-1ß-induced Reduction of CD44 Ser-325 Phosphorylation in Human Epidermal Keratinocytes Promotes CD44 Homomeric Complexes, Binding to Ezrin, and Extended, Monocyte-adhesive Hyaluronan Coats.
J Biol Chem
; 290(19): 12379-93, 2015 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25809479
7.
Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3.
J Biol Chem
; 290(18): 11479-90, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25795779
8.
Hexosamine biosynthesis in keratinocytes: roles of GFAT and GNPDA enzymes in the maintenance of UDP-GlcNAc content and hyaluronan synthesis.
Glycobiology
; 26(7): 710-22, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26887390
9.
High extent of O-GlcNAcylation in breast cancer cells correlates with the levels of HAS enzymes, accumulation of hyaluronan, and poor outcome.
Breast Cancer Res Treat
; 160(2): 237-247, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27683279
10.
Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion.
Exp Cell Res
; 337(1): 1-15, 2015 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26222208
11.
Extracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes.
J Biol Chem
; 289(26): 18569-81, 2014 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24847057
12.
Rab10-mediated endocytosis of the hyaluronan synthase HAS3 regulates hyaluronan synthesis and cell adhesion to collagen.
J Biol Chem
; 289(12): 8375-89, 2014 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24509846
13.
The reciprocal association between mammographic breast density, hyaluronan synthesis and patient outcome.
Breast Cancer Res Treat
; 153(3): 625-34, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26362804
14.
High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer.
Histopathology
; 66(6): 873-83, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25387851
15.
Decreased hyaluronidase 1 expression is associated with early disease recurrence in human endometrial cancer.
Gynecol Oncol
; 137(1): 152-9, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25584766
16.
Low dose ultraviolet B irradiation increases hyaluronan synthesis in epidermal keratinocytes via sequential induction of hyaluronan synthases Has1-3 mediated by p38 and Ca2+/calmodulin-dependent protein kinase II (CaMKII) signaling.
J Biol Chem
; 288(25): 17999-8012, 2013 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23645665
17.
Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.
J Biol Chem
; 288(8): 5973-83, 2013 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23303191
18.
Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival.
Breast Cancer Res Treat
; 143(2): 277-86, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24337597
19.
Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes.
Histochem Cell Biol
; 141(1): 17-31, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24057227
20.
Hyaluronan production enhances shedding of plasma membrane-derived microvesicles.
Exp Cell Res
; 319(13): 2006-2018, 2013 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23732660