RESUMO
Palhinosides A-H (1-8), new flavone glucosidic truxinate esters, including ß-truxinate and µ-truxinate forms, were isolated from Palhinhaea cernua. Their structures were elucidated by extensive spectroscopic methods and chemical analyses. The flavone glucoside cyclodimers possess a unique cyclobutane ring in their carbon scaffolds. Compounds 2-7 represent three pairs of stereoisomers (2/3, 4/5, 6/7). The protective effects of 1-8 against the damage of HT-22 cells induced by l-glutamate were evaluated, and compounds 4 and 5 showed better neuroprotective effects than the positive control, Trolox.
Assuntos
Flavonas/isolamento & purificação , Lycopodiaceae/química , Triterpenos/isolamento & purificação , Ésteres , Flavonas/química , Glucosídeos , Estrutura Molecular , Fármacos Neuroprotetores , Triterpenos/químicaRESUMO
A new cyclic diarylheptanoid (1) and a new flavone glucoside (2), along with seven known compounds, were isolated from the green peel of Juglans mandshurica. Their structures were elucidated based on extensive spectroscopic analyses. Moreover, the cytotoxicity against NCI-H460, A549, and K562 cancer cells of compounds 1-6 was evaluated. The results showed that compound 3 exhibited moderate inhibitory potency against the growth of three cell lines.
Assuntos
Antineoplásicos Fitogênicos/isolamento & purificação , Diarileptanoides/isolamento & purificação , Medicamentos de Ervas Chinesas/isolamento & purificação , Flavonas/isolamento & purificação , Glucosídeos/isolamento & purificação , Juglans/química , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/farmacologia , Diarileptanoides/química , Diarileptanoides/farmacologia , Ensaios de Seleção de Medicamentos Antitumorais , Medicamentos de Ervas Chinesas/química , Medicamentos de Ervas Chinesas/farmacologia , Flavonas/química , Flavonas/farmacologia , Glucosídeos/química , Glucosídeos/farmacologia , Células Hep G2 , Humanos , Células K562 , Estrutura Molecular , Extratos Vegetais/químicaRESUMO
Two new selaginellin derivatives selaginellin P (1) and selaginellin Q (2) were isolated from Selaginella tamariscina. The structures of 1 and 2 were established as 2,4'-dihydroxy-4-methyl-3-[(4-hydroxyphenyl)ethynyl]biphene (1) and 2,4'-dihydroxy-3-[(4-hydroxyphenyl)ethynyl]biphene (2) on the basis of spectroscopic means including HR-ESI-MS, 1D, and 2D NMR experiments.
Assuntos
Compostos de Bifenilo/isolamento & purificação , Medicamentos de Ervas Chinesas/isolamento & purificação , Selaginellaceae/química , Compostos de Bifenilo/química , Medicamentos de Ervas Chinesas/química , Estrutura Molecular , Ressonância Magnética Nuclear BiomolecularRESUMO
A chalcone-flavonone type biflavonoid, trichocladabiflavone A (1), along with eight known biflavonoids (2-9) were isolated from the 70% EtOH extract of Selaginella trichoclada. Their structures were elucidated by extensive spectroscopic analyses. Compound 1 was the first chalcone-flavonone type biflavonoid reported in the genus Selaginella. Moreover, compound 1 exhibited moderate cytotoxicity against DU145, MCF-7 and PC3 human cancer cell lines.
Assuntos
Biflavonoides , Chalcona , Chalconas , Selaginellaceae , Biflavonoides/química , Biflavonoides/farmacologia , Chalcona/química , Humanos , Estrutura Molecular , Extratos Vegetais/química , Selaginellaceae/químicaRESUMO
Three new neolignans, lycocernuasides B-D (1-3), three new serratane triterpenoids, lycernuic ketones D (8) and E (9), and lycernuic A (10), together with six known compounds, were isolated from the 75% aqueous EtOH extract of Palhinhaea cernua. Their structures and absolute configurations were established primarily by NMR, HRESIMS and circular dichroism (CD). All compounds were evaluated the inhibitory activities of xanthine oxidase. Compounds 1-3 displayed moderate inhibitory effects on xanthine oxidase with IC50 values of 30.36µM, 42.65µM and 35.33µM, respectively.
Assuntos
Lignanas/química , Lycopodiaceae/química , Triterpenos/química , Xantina Oxidase/antagonistas & inibidores , Animais , Bovinos , Inibidores Enzimáticos/química , Inibidores Enzimáticos/isolamento & purificação , Lignanas/isolamento & purificação , Estrutura Molecular , Triterpenos/isolamento & purificaçãoRESUMO
Six new flavonoids, unciflavones A-F (1-6), have been isolated from medicinal plant Selaginella uncinata (Desv.) Spring. Their structures were established on the basis of extensive NMR analysis including 1D NMR ((1)H, (13)C and DEPT) and 2D NMR (COSY, HSQC, HMBC) experiments as well as HRESIMS analysis. All compounds possess exceptional structural features with an aryl substituent at the C-8 position, which are uncommonly encountered in natural resources and firstly reported in genus Selaginella.