Detalhe da pesquisa
1.
TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation.
Mol Cell
; 41(4): 458-70, 2011 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21329883
2.
Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties.
J Biol Chem
; 290(26): 16330-42, 2015 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25953898
3.
Patient-Specific Vascularized Tumor Model: Blocking TAM Recruitment with Multispecific Antibodies Targeting CCR2 and CSF-1R.
bioRxiv
; 2023 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38076998
4.
BCA101 Is a Tumor-Targeted Bifunctional Fusion Antibody That Simultaneously Inhibits EGFR and TGFß Signaling to Durably Suppress Tumor Growth.
Cancer Res
; 83(11): 1883-1904, 2023 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37074042
5.
Inhibition of IRF5 cellular activity with cell-penetrating peptides that target homodimerization.
Sci Adv
; 6(20): eaay1057, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32440537
6.
When translation meets metabolism: multiple links to diabetes.
Endocr Rev
; 24(1): 91-101, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12588811
7.
Emerging host cell targets for hepatitis C therapy.
Drug Discov Today
; 12(5-6): 209-17, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17331885
8.
The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling.
Cell Signal
; 18(9): 1473-81, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16427251
9.
The very C-terminus of protein kinase Cepsilon is critical for the full catalytic competence but its hydrophobic motif is dispensable for the interaction with 3-phosphoinositide-dependent kinase-1.
Cell Signal
; 18(6): 807-18, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16137858
10.
Hepatitis C therapeutics: current status and emerging strategies.
Nat Rev Drug Discov
; 1(11): 867-81, 2002 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-12415247
11.
Cytokine-activated natural killer cells exert direct killing of hepatoma cells harboring hepatitis C virus replicons.
J Interferon Cytokine Res
; 26(12): 854-65, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17238828
12.
Selective role of PKCbeta enzymatic function in regulating cell survival mediated by B cell antigen receptor cross-linking.
Immunol Lett
; 105(1): 83-9, 2006 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16564096
13.
Data for the crystal structure of APRIL-BAFF-BAFF heterotrimer.
Data Brief
; 6: 438-44, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26870754
14.
Discovery of small-molecule inhibitors of HCV NS3-4A protease as potential therapeutic agents against HCV infection.
Curr Med Chem
; 12(20): 2317-42, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16181135
15.
Strategies for hepatitis C therapeutic intervention: now and next.
Curr Opin Pharmacol
; 4(5): 465-70, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15351350
16.
Emerging and diverse roles of protein kinase C in immune cell signalling.
Biochem J
; 376(Pt 3): 545-52, 2003 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14570590
17.
Tocilizumab, a humanized anti-IL-6R antibody, as an emerging therapeutic option for rheumatoid arthritis: molecular and cellular mechanistic insights.
Int Rev Immunol
; 34(3): 265-79, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25099958
18.
Combined inhibition of tumor necrosis factor α and interleukin-17 as a therapeutic opportunity in rheumatoid arthritis: development and characterization of a novel bispecific antibody.
Arthritis Rheumatol
; 67(1): 51-62, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25303306
19.
Synergistic antiviral activity of human interferon combinations in the hepatitis C virus replicon system.
J Interferon Cytokine Res
; 23(5): 247-57, 2003 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12804067
20.
Small-molecule inhibitors of spleen tyrosine kinase as therapeutic agents for immune disorders: will promise meet expectations?
Future Med Chem
; 6(16): 1811-27, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25407369