Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Epitopes in the Glycosylphosphatidylinositol Attachment Signal Peptide of Trypanosoma cruzi Mucin Proteins Generate Robust but Delayed and Nonprotective CD8+ T Cell Responses.

Bunkofske, Molly E; Perumal, Natasha; White, Brooke; Strauch, Eva-Maria; Tarleton, Rick.

J Immunol ; 210(4): 420-430, 2023 02 15.

Artigo em Inglês | MEDLINE | ID: mdl-36603035

2.

cGAS-STING Pathway Activation during Trypanosoma cruzi Infection Leads to Tissue-Dependent Parasite Control.

Perumal, Natasha; White, Brooke; Sanchez-Valdez, Fernando; Tarleton, Rick L.

J Immunol ; 211(7): 1123-1133, 2023 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-37603014

3.

Avoiding Clinical Trial Failures in Neglected Tropical Diseases: The Example of Chagas Disease.

Tarleton, Rick L.

Clin Infect Dis ; 76(8): 1516-1520, 2023 04 17.

Artigo em Inglês | MEDLINE | ID: mdl-36373213

4.

Frequency Variation and Dose Modification of Benznidazole Administration for the Treatment of Trypanosoma cruzi Infection in Mice, Dogs, and Nonhuman Primates.

Bustamante, Juan M; White, Brooke E; Wilkerson, Gregory K; Hodo, Carolyn L; Auckland, Lisa D; Wang, Wei; McCain, Stephanie; Hamer, Sarah A; Saunders, Ashley B; Tarleton, Rick L.

Antimicrob Agents Chemother ; 67(5): e0013223, 2023 05 17.

Artigo em Inglês | MEDLINE | ID: mdl-37039666

5.

Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease.

Wang, Wei; Peng, Duo; Baptista, Rodrigo P; Li, Yiran; Kissinger, Jessica C; Tarleton, Rick L.

PLoS Pathog ; 17(1): e1009254, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-33508020

6.

DIAGNOSIS AND TREATMENT OF A NATURAL INFECTION WITH TRYPANOSOMA CRUZI (CHAGAS DISEASE) IN A SYMPTOMATIC DE BRAZZA'S MONKEY (CERCOPITHECUS NEGLECTUS) IN ALABAMA.

McCain, Stephanie; Sim, Richard R; Weidner, Bridget; Rivas, Anne E; White, Brooke; Auckland, Lisa D; Tarleton, Rick L; Hamer, Sarah.

J Zoo Wildl Med ; 54(2): 412-416, 2023 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-37428708

7.

Cutting Edge: Augmenting Muscle MHC Expression Enhances Systemic Pathogen Control at the Expense of T Cell Exhaustion.

Pack, Angela D; Tarleton, Rick L.

J Immunol ; 205(3): 573-578, 2020 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-32591392

8.

Reduced Trypanosoma cruzi-specific humoral response and enhanced T cell immunity after treatment interruption with benznidazole in chronic Chagas disease.

Castro Eiro, Melisa D; Natale, María A; Alvarez, María G; Shen, Huifeng; Viotti, Rodolfo; Lococo, Bruno; Bua, Jacqueline; Nuñez, Myriam; Bertocchi, Graciela L; Albareda, María C; Cesar, Gonzalo; Tarleton, Rick L; Laucella, Susana A.

J Antimicrob Chemother ; 76(6): 1580-1592, 2021 05 12.

Artigo em Inglês | MEDLINE | ID: mdl-33693664

9.

New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma cruzi: Clinical, Parasitological, and Serological Assessment after Three Years of Follow-Up.

Álvarez, María Gabriela; Ramírez, Juan Carlos; Bertocchi, Graciela; Fernández, Marisa; Hernández, Yolanda; Lococo, Bruno; Lopez-Albizu, Constanza; Schijman, Alejandro; Cura, Carolina; Abril, Marcelo; Laucella, Susana; Tarleton, Rick L; Natale, María Ailen; Castro Eiro, Melisa; Sosa-Estani, Sergio; Viotti, Rodolfo.

Antimicrob Agents Chemother ; 64(9)2020 08 20.

Artigo em Inglês | MEDLINE | ID: mdl-32571827

10.

Highly competent, non-exhausted CD8+ T cells continue to tightly control pathogen load throughout chronic Trypanosoma cruzi infection.

Pack, Angela D; Collins, Matthew H; Rosenberg, Charles S; Tarleton, Rick L.

PLoS Pathog ; 14(11): e1007410, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30419010

11.

Perturbed T cell IL-7 receptor signaling in chronic Chagas disease.

Albareda, M Cecilia; Perez-Mazliah, Damián; Natale, M Ailén; Castro-Eiro, Melisa; Alvarez, María G; Viotti, Rodolfo; Bertocchi, Graciela; Lococo, Bruno; Tarleton, Rick L; Laucella, Susana A.

J Immunol ; 194(8): 3883-9, 2015 Apr 15.

Artigo em Inglês | MEDLINE | ID: mdl-25769928

12.

Long-Term Immunity to Trypanosoma cruzi in the Absence of Immunodominant trans-Sialidase-Specific CD8+ T Cells.

Rosenberg, Charles S; Zhang, Weibo; Bustamante, Juan M; Tarleton, Rick L.

Infect Immun ; 84(9): 2627-38, 2016 09.

Artigo em Inglês | MEDLINE | ID: mdl-27354447

13.

Recombination-driven generation of the largest pathogen repository of antigen variants in the protozoan Trypanosoma cruzi.

Weatherly, D Brent; Peng, Duo; Tarleton, Rick L.

BMC Genomics ; 17(1): 729, 2016 09 13.

Artigo em Inglês | MEDLINE | ID: mdl-27619017

14.

Reaching for the Holy Grail: insights from infection/cure models on the prospects for vaccines for Trypanosoma cruzi infection.

Bustamante, Juan; Tarleton, Rick.

Mem Inst Oswaldo Cruz ; 110(3): 445-51, 2015 May.

Artigo em Inglês | MEDLINE | ID: mdl-25946159

15.

New, combined, and reduced dosing treatment protocols cure Trypanosoma cruzi infection in mice.

Bustamante, Juan M; Craft, Julie M; Crowe, Byron D; Ketchie, Sarah A; Tarleton, Rick L.

J Infect Dis ; 209(1): 150-62, 2014 Jan 01.

Artigo em Inglês | MEDLINE | ID: mdl-23945371

16.

Evidence for the role of vacuolar soluble pyrophosphatase and inorganic polyphosphate in Trypanosoma cruzi persistence.

Galizzi, Melina; Bustamante, Juan M; Fang, Jianmin; Miranda, Kildare; Soares Medeiros, Lia C; Tarleton, Rick L; Docampo, Roberto.

Mol Microbiol ; 90(4): 699-715, 2013 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-24033456

17.

Frequency of IFNÎ³-producing T cells correlates with seroreactivity and activated T cells during canine Trypanosoma cruzi infection.

Hartley, Ashley N; Cooley, Gretchen; Gwyn, Sarah; Orozco, Marcela M; Tarleton, Rick L.

Vet Res ; 45: 6, 2014 Jan 23.

Artigo em Inglês | MEDLINE | ID: mdl-24456537

18.

Positive clinical outcome using a modified dosing regimen of benznidazole in dogs at high risk for infection or acutely infected with Trypanosoma cruzi.

Lim, Sukjung; Collins, Stephanie; Hamer, Sarah A; Tarleton, Rick L; Saunders, Ashley B.

J Vet Intern Med ; 38(3): 1725-1729, 2024.

Artigo em Inglês | MEDLINE | ID: mdl-38500407

19.

Effective drug discovery in Chagas disease.

Tarleton, Rick L.

Trends Parasitol ; 39(6): 423-431, 2023 06.

Artigo em Inglês | MEDLINE | ID: mdl-37024318

20.

Delayed Activation of T Cells at the Site of Infection Facilitates the Establishment of Trypanosoma cruzi in Both Naive and Immune Hosts.

Padilla, Angel M; Rosenberg, Charles; Cook, Peter; Sanchez-Valdez, Fernando; McElhannon, Caroline; Tarleton, Rick L.

mSphere ; 8(1): e0060122, 2023 02 21.

Artigo em Inglês | MEDLINE | ID: mdl-36695605

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