Detalhe da pesquisa
1.
S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy.
Mol Cell
; 83(19): 3485-3501.e11, 2023 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37802024
2.
Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Mol Cell
; 81(24): 5025-5038.e10, 2021 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34890564
3.
Inhibition of vaccinia virus L1 N-myristoylation by the host N-myristoyltransferase inhibitor IMP-1088 generates non-infectious virions defective in cell entry.
PLoS Pathog
; 18(10): e1010662, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36215331
4.
Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion.
PLoS Biol
; 19(10): e3001408, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34695132
5.
XerC Is Required for the Repair of Antibiotic- and Immune-Mediated DNA Damage in Staphylococcus aureus.
Antimicrob Agents Chemother
; 67(3): e0120622, 2023 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36802166
6.
Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1.
Nat Chem Biol
; 17(7): 776-783, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33859413
7.
Discovery of a Potent Deubiquitinase (DUB) Small-Molecule Activity-Based Probe Enables Broad Spectrum DUB Activity Profiling in Living Cells.
Angew Chem Int Ed Engl
; 62(47): e202311190, 2023 11 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37779326
8.
A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion.
J Am Chem Soc
; 144(49): 22493-22504, 2022 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36413626
9.
UCHL1 as a novel target in breast cancer: emerging insights from cell and chemical biology.
Br J Cancer
; 126(1): 24-33, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34497382
10.
D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition.
Nat Chem Biol
; 16(6): 686-694, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32203411
11.
How Structures of Complement Complexes Guide Therapeutic Design.
Subcell Biochem
; 96: 273-295, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33252733
12.
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis.
Proc Natl Acad Sci U S A
; 116(4): 1414-1419, 2019 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30617067
13.
Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets.
Trends Biochem Sci
; 42(7): 566-581, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28602500
14.
A Suite of Activity-Based Probes To Dissect the KLK Activome in Drug-Resistant Prostate Cancer.
J Am Chem Soc
; 143(23): 8911-8924, 2021 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34085829
15.
Analysis of a fully infectious bio-orthogonally modified human virus reveals novel features of virus cell entry.
PLoS Pathog
; 15(10): e1007956, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31589653
16.
Whole Proteome Profiling of N-Myristoyltransferase Activity and Inhibition Using Sortase A.
Mol Cell Proteomics
; 18(1): 115-126, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30341083
17.
Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)*.
Angew Chem Int Ed Engl
; 60(24): 13542-13547, 2021 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33768725
18.
Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity.
J Am Chem Soc
; 142(28): 12020-12026, 2020 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32579346
19.
Activity-Based Protein Profiling for the Study of Parasite Biology.
Curr Top Microbiol Immunol
; 420: 155-174, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30105424
20.
Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells.
Int J Mol Sci
; 21(21)2020 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33182425