Detalhe da pesquisa
1.
HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice.
Hepatology
; 78(3): 929-942, 2023 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36896966
2.
Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics.
PLoS Comput Biol
; 19(8): e1011309, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37535676
3.
Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocytes accumulating hepatitis B surface antigen.
PLoS Pathog
; 17(5): e1009228, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33979382
4.
A novel cDNA-uPA/SCID/Rag2-/- /Jak3-/- mouse model for hepatitis virus infection and reconstruction of human immune system.
J Viral Hepat
; 30(3): 262-272, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36575861
5.
Understanding Hepatitis B Virus Dynamics and the Antiviral Effect of Interferon Alpha Treatment in Humanized Chimeric Mice.
J Virol
; 95(14): e0049220, 2021 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33910953
6.
Novel drug resistance-associated substitutions against pibrentasvir emerged in genotype 1b hepatitis C virus-infected human hepatocyte transplanted mice.
Biochem Biophys Res Commun
; 559: 78-83, 2021 06 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33932902
7.
Humanized liver mouse model with transplanted human hepatocytes from patients with ornithine transcarbamylase deficiency.
J Inherit Metab Dis
; 44(3): 618-628, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33336822
8.
Loss of lysophosphatidic acid receptor 1 in hepatocytes reduces steatosis via down-regulation of CD36.
Prostaglandins Other Lipid Mediat
; 156: 106577, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34147666
9.
Transduction Properties of an Adenovirus Vector Containing Sequences Complementary to a Liver-Specific microRNA, miR-122a, in the 3'-Untranslated Region of the E4 Gene in Human Hepatocytes from Chimeric Mice with Humanized Liver.
Biol Pharm Bull
; 44(10): 1506-1513, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34602559
10.
Signal Activation of Hepatitis B Virus-Related Hepatocarcinogenesis by Up-regulation of SUV39h1.
J Infect Dis
; 222(12): 2061-2070, 2020 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32514521
11.
Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice.
Semin Liver Dis
; 40(2): 189-212, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32074631
12.
Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: integration with hepatic drug metabolism.
Xenobiotica
; 50(11): 1370-1379, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32401667
13.
Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice.
J Gen Virol
; 100(7): 1123-1131, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31199224
14.
Acute hepatitis B virus infection in humanized chimeric mice has multiphasic viral kinetics.
Hepatology
; 68(2): 473-484, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29572897
15.
Coordinated cytochrome P450 expression in mouse liver and intestine under different dietary conditions during liver regeneration after partial hepatectomy.
Toxicol Appl Pharmacol
; 370: 133-144, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30880217
16.
Prediction of Human Hepatic Clearance for Cytochrome P450 Substrates via a New Culture Method Using the Collagen Vitrigel Membrane Chamber and Fresh Hepatocytes Isolated from Liver Humanized Mice.
Biol Pharm Bull
; 42(3): 348-353, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30828066
17.
Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver.
Biol Pharm Bull
; 42(8): 1366-1375, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31366871
18.
The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice.
BMC Genomics
; 19(1): 443, 2018 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29879903
19.
Limitations of daclatasvir/asunaprevir plus beclabuvir treatment in cases of NS5A inhibitor treatment failure.
J Gen Virol
; 99(8): 1058-1065, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29916799
20.
Prevalence of NS5A resistance associated variants in NS5A inhibitor treatment failures and an effective treatment for NS5A-P32 deleted hepatitis C virus in humanized mice.
Biochem Biophys Res Commun
; 500(2): 152-157, 2018 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29621544