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1.
Gan To Kagaku Ryoho ; 51(3): 343-345, 2024 Mar.
Artigo em Japonês | MEDLINE | ID: mdl-38494826

RESUMO

Immune checkpoint inhibitors are known to produce immune-related adverse events(irAE)that require medical management. Herein, we report a case of a patient treated with pembrolizumab who experienced a Grade 3 interrupted skin disorder. The patient is a 67-year-old female diagnosed with right maxillary gingival squamous cell carcinoma(cT4aN0M0, Stage ⅣA)and underwent partial right maxillectomy, right extended supra-omohyoid neck dissection, and maxillary reconstruction using a forearm flap. Six months postoperatively, late lymph node metastases with extracapsular spread was found in the right buccal lymph node and the left neck, and the patient underwent right buccal lymphadenectomy and left modified radical neck dissection. After postoperative combined chemoradiotherapy(cisplatin plus IMRT)followed by 13 courses of cetuximab plus paclitaxel, a recurrent lesion was found in the right buccal region. After 8 courses of pembrolizumab, a skin rash appeared on the forearm, chest, and back, which was diagnosed as Grade 3 irAE, requiring hospitalization. The patient was re-instituted after waiting for improvement of the skin disorder. The pembrolizumab at 75% reduction dose was re-administrated, and the patient has been followed up so far.


Assuntos
Neoplasias Gengivais , Neoplasias de Cabeça e Pescoço , Idoso , Feminino , Humanos , Anticorpos Monoclonais Humanizados/efeitos adversos , Cetuximab , Neoplasias de Cabeça e Pescoço/tratamento farmacológico , Paclitaxel
2.
Dysphagia ; 38(4): 1096-1105, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-36243794

RESUMO

Patients with oral cancer have poor nutritional status before treatment. However, there have been no reports of the detailed evaluation of preoperative oral function in patients with oral squamous cell carcinoma (OSCC). Therefore, this study aimed to evaluate the preoperative oral function of patients with OSCC and examine the relationship with nutritional status. Oral function measurements (microorganisms, oral dryness, occlusal force, tongue pressure, masticatory function, Eating Assessment Tool, and Postoperative Oral Dysfunction Scale) and Mini Nutritional Assessment-Short Form (MNA-SF) data were collected from 51 patients with OSCC (men: 37, women: 14, mean age: 72.1 years) who visited the Shimane University Hospital, Department of Oral and Maxillofacial Surgery, from September 2019 to September 2021. The tongue was the most prevalent primary gingiva site [22 patients (43.1%)], and 36 patients (70.6%) had advanced cancer. Comparisons between nutritional status and each related factor revealed significant differences in the number of individuals in the household, cancer stage, presence of pulmonary disease, number of teeth, microorganisms (grade), and masticatory function (mg/dL) (p < 0.05). Multiple regression analysis using the total MNA-SF score as the dependent variable with adjustment for confounding factors showed significant association between oral dryness and tongue pressure (p < 0.05). No significant association was found for the Eating Assessment Tool or Postoperative Oral Dysfunction scale. Patients with OSCC may have decreased oral function because of the tumor at the time of diagnosis, which causes a decline in nutritional status. Preoperative interventions are necessary to improve nutrition based on the state of oral function.


Assuntos
Carcinoma de Células Escamosas , Desnutrição , Neoplasias Bucais , Masculino , Humanos , Feminino , Idoso , Estudos Transversais , Língua/fisiologia , Neoplasias Bucais/complicações , Neoplasias Bucais/cirurgia , Pressão , Estado Nutricional , Avaliação Nutricional
3.
Gan To Kagaku Ryoho ; 50(13): 1485-1488, 2023 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-38303316

RESUMO

In Japan, the incidence of double cancers is increasing due to the rise in cancer prevalence in the super-aging society, and the frequency is particularly high among patients with head and neck cancer. To the best of our knowledge, there has been only 1 reported case of metachronous double cancer with parotid gland cancer and tongue squamous cell carcinoma, and herein we report the outline of this case. The patient was a 70-year-old male with a smoking history. In 2017, a total parotidectomy and neck dissection for adenocarcinoma of the right parotid gland were performed at the otolaryngology department, followed by concurrent chemoradiotherapy as postoperative therapy. Pathological examination revealed adenocarcinoma NOS(pT4aN2bM0, Stage ⅣA). There was no recurrence or metastasis, and the patient was recovering well. However, in October 2022, the patient presented to the hospital with a chief complaint of pain at the right margin of the tongue. At the initial consultation, an ulcerative lesion with a slightly unclear boundary and maximum diameter of approximately 15 mm was observed on the right margin of the tongue. Since epithelialization was observed in some regions, it was diagnosed as intractable stomatitis and the patient was put under observation for the time being. With no signs of healing during the follow- up examination a month later and considering the possibility of malignant tumors, a total excision of tongue lesion was performed. Pathological examination revealed well-differentiated squamous cell carcinoma(pT1N0M0, Stage Ⅰ). Going forward, we plan to conduct careful follow-up observations with the possibility of further metachronous double cancer occurrences in mind.


Assuntos
Adenocarcinoma , Carcinoma de Células Escamosas , Neoplasias Parotídeas , Neoplasias da Língua , Masculino , Humanos , Idoso , Carcinoma de Células Escamosas/cirurgia , Carcinoma de Células Escamosas/patologia , Glândula Parótida/patologia , Glândula Parótida/cirurgia , Neoplasias da Língua/cirurgia , Neoplasias da Língua/patologia , Neoplasias Parotídeas/patologia , Neoplasias Parotídeas/secundário , Neoplasias Parotídeas/cirurgia , Adenocarcinoma/patologia
4.
Gan To Kagaku Ryoho ; 50(3): 346-350, 2023 Mar.
Artigo em Japonês | MEDLINE | ID: mdl-36927905

RESUMO

Multidisciplinary treatment, combining ablative surgery and reconstruction, radiotherapy, and chemotherapy, is used to treat advanced oral cancers. In this study, we report a case of extensive osteoradionecrosis of the mandible following multidisciplinary treatment for tongue cancer, in which a computer-assisted, patient-specific custom-made cutting guide and reconstruction plate(TruMatch® )were used to improve the patient's facial morphology and oral-maxillofacial functioning. A 70-year-old man received multidisciplinary treatment for squamous cell carcinoma of the left side of the tongue (cT3N2bM0, cStage ⅣA)at a previous hospital. Seven years postoperatively, bilateral osteoradionecrosis of the mandible developed, and the patient was referred to our department for further treatment. Since the lesions were extensive, we planned reconstructive surgery using the TruMatch® system in collaboration with the plastic surgery department of our hospital. Surgery was performed precisely and accurately according to the preoperative simulation. Postoperatively, the patient's recovery was uneventful. The TruMatch® system enables us to achieve good morphological and comprehensive functional oral-maxillofacial reconstruction.


Assuntos
Carcinoma de Células Escamosas , Reconstrução Mandibular , Osteorradionecrose , Procedimentos de Cirurgia Plástica , Masculino , Humanos , Idoso , Osteorradionecrose/etiologia , Osteorradionecrose/cirurgia , Osteorradionecrose/patologia , Mandíbula/cirurgia , Mandíbula/patologia , Carcinoma de Células Escamosas/cirurgia , Carcinoma de Células Escamosas/patologia
5.
Gan To Kagaku Ryoho ; 50(13): 1595-1599, 2023 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-38303353

RESUMO

Radical tumor resection for oral cancer can cause morphological and esthetic disorders and oral and maxillofacial dysfunction and maintaining a social life could become challenging, especially in the adolescents and young adults(AYA)generation. Conversely, chemoradiotherapy for young patients may cause adverse reactions such as impaired fertility and late side effects of radiation. Therefore, treatment should be performed cautiously. We report a case of AYA generation patient who underwent salvage surgery and maxillofacial reconstruction for recurrent tongue cancer after super-selective intra-arterial chemoradiotherapy. The patient was a 30-year-old woman who was 20 weeks pregnant. She was diagnosed with Stage Ⅲ squamous cell carcinoma of the right tongue, cT3N0M0. After abortion, the patient underwent super-selective intra-arterial chemoradiotherapy and achieved a complete response. However, 13 years later, a recurrence of Stage ⅣA tongue cancer, r- cT4aN2bM0, was reported. Additionally, the patient had osteoradionecrosis. We performed radical tumor resection(bilateral neck dissection plus subtotal glossectomy plus segmental mandibulectomy)and maxillofacial reconstruction with a fibula flap. Subsequently, we performed occlusal reconstruction treatment using dental implants. Three years postoperatively, no tumor recurrence was observed, and the patient was satisfied with the restored morpho-aesthetic and maxillo-oral functions.


Assuntos
Neoplasias Bucais , Neoplasias da Língua , Adulto , Feminino , Humanos , Quimiorradioterapia , Retalhos Cirúrgicos/patologia , Língua/patologia , Neoplasias da Língua/cirurgia , Neoplasias da Língua/patologia , Gravidez
6.
Gan To Kagaku Ryoho ; 50(13): 1938-1943, 2023 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-38303258

RESUMO

The treatment of advanced lower gingival carcinoma requires postoperative chemoradiotherapy; therefore, simultaneous hard-tissue reconstruction may not be indicated. In these cases, mandibular reconstruction is performed using a temporal reconstruction plate and various skin flaps. Herein, we reported 2 cases of advanced lower gingival carcinoma treated with a novel computer-assisted patient-specific, fully custom-made mandibular reconstruction plate system(Cosmofix®)in combination with a pedicle/free flap. In case 1, an 80-year-old female patient was diagnosed with right lower gingival carcinoma( cT4aN3bM0, Stage ⅣB). Under general anesthesia, she underwent tracheostomy, bilateral neck dissection, segmental mandibulectomy, and mandibular reconstruction using Cosmofix® in combination with an ulnar forearm free flap. In case 2, an 81-year-old male patient was diagnosed with right lower gingival carcinoma(cT4aN2bM0, Stage ⅣA). The patient underwent maintenance dialysis and required minimally invasive surgery using a pedicle flap. Under general anesthesia, the patient underwent tracheostomy, right modified radical neck dissection, segmental mandibulectomy, and mandibular reconstruction using Cosmofix® in combination with a pectoralis major myocutaneous flap. Postoperative facial morphology, occlusion, eating, swallowing, articulation, and other dysfunctions were minimal in both the cases. Adjuvant chemoradiotherapy was recommended. In conclusion, the utilization of the Cosmofix® system enabled both esthetic and functional reconstruction following segmental mandibulectomy for advanced lower gingival carcinoma.


Assuntos
Carcinoma , Neoplasias Gengivais , Reconstrução Mandibular , Procedimentos de Cirurgia Plástica , Masculino , Feminino , Humanos , Idoso de 80 Anos ou mais , Neoplasias Gengivais/cirurgia , Retalhos Cirúrgicos/cirurgia , Carcinoma/cirurgia
7.
Gan To Kagaku Ryoho ; 50(13): 1934-1937, 2023 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-38303257

RESUMO

Dysphagia is a major postoperative complication in patients with locally advanced oral cancer. In this case report, we describe the effect of the hyoid bone suspension technique on the preservation of swallowing function after total glossectomy and pectoralis major musculocutaneous flap reconstruction for locally advanced tongue cancer. Case: A 72-year-old Japanese male was diagnosed with advanced squamous cell carcinoma on the left side of his tongue(cT4aN2cM0, cStage ⅣA). Under general anesthesia, the patient underwent a tracheotomy, bilateral modified radical neck dissection type Ⅲ, total glossectomy, and reconstruction with a left pectoralis major musculocutaneous flap(PMMC flap). Intraoperatively, the PMMC flap was designed to have a heart shape of 11×6 cm and was elevated. Subsequently, holes were made at the lower edge of the mandible, and the hyoid bone was suspended and fixed to the mandibular border using 2-0 nylon sutures. The postoperative course was uneventful; the flap was completely engrafted and was in good condition. The hyoid bone suspension technique can reproduce the pharyngeal phase of swallowing, and the palatal augmentation prosthesis helps to improve food mass feeding and preserve the swallowing function.


Assuntos
Retalho Miocutâneo , Procedimentos de Cirurgia Plástica , Neoplasias da Língua , Humanos , Masculino , Idoso , Glossectomia/métodos , Neoplasias da Língua/cirurgia , Neoplasias da Língua/patologia , Retalho Miocutâneo/cirurgia , Retalho Miocutâneo/transplante , Osso Hioide/cirurgia , Osso Hioide/patologia , Músculos Peitorais/cirurgia , Músculos Peitorais/transplante , Deglutição , Língua/patologia , Língua/cirurgia
8.
Gan To Kagaku Ryoho ; 49(13): 1534-1537, 2022 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-36733126

RESUMO

Many patients with mental retardation have a limited awareness of abnormalities in the oral cavity, making early detection of oral cancer difficult. Moreover, during examination and treatment, these patients may not understand well-intentioned verbal explanations and may express their anxiety through nonverbal communication. Herein we discuss a case in which favorable results were obtained when surgical treatment was performed on a maxillary gingival carcinoma patient with mental retardation. The patient was a 61-year-old man who was admitted to our hospital with maxillary gingival pain. A biopsy revealed well-differentiated oral squamous cell carcinoma(cT4aN0M0, Stage ⅣA). Hemi-maxillectomy was performed and postoperative recovery was uneventful. A maxillary prosthesis was provided for oral rehabilitation. At the 5-year follow-up, there were no signs of recurrence or metastasis. This case illustrates the importance of collaboration between oral maxillofacial surgeons and specialists from related departments for the comprehensive management of patients with mental retardation.


Assuntos
Neoplasias Ósseas , Carcinoma de Células Escamosas , Neoplasias Gengivais , Deficiência Intelectual , Neoplasias Maxilares , Neoplasias Bucais , Neoplasias Cutâneas , Masculino , Humanos , Pessoa de Meia-Idade , Neoplasias Gengivais/complicações , Neoplasias Gengivais/cirurgia , Carcinoma de Células Escamosas/complicações , Carcinoma de Células Escamosas/cirurgia , Carcinoma de Células Escamosas/patologia , Neoplasias Maxilares/complicações , Neoplasias Maxilares/cirurgia , Neoplasias Maxilares/patologia
9.
Gan To Kagaku Ryoho ; 49(13): 1754-1757, 2022 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-36732989

RESUMO

Recently, the number of survivors that had oral cancer has increased, but deterioration in the quality of life of patients concerning oral function and cosmetic appearance has become problematic. Prosthodontic dentures usefully treat jaw defects after maxillary resection for cancer, but advances in microsurgery have rendered the possibility to reconstruct maxillary defect and oral cavity using a microvascular flap. Here, we describe 2-stage treatment after 35 years postoperatively. We restored the maxillofacial function using microvascular flaps and partial denture. The patient was a 59-year-old woman who underwent left lateral maxillectomy 35 years previously to treat an advanced left maxilla gingival carcinoma. A maxillary prosthesis was applied, requiring repeated adjustments and refabrications. The patient visited to obtain improvements for oral and maxillofacial functions and long-term quality of life. The left maxillary bone defect was 45×50 mm in area. Collaborating with the Department of Plastic and Reconstructive Surgery, the patient underwent reconstructive treatment using a microvascular forearm flap and partial denture. The patient's progress was excellent; eating, swallowing, and articulation improved. For 1 year postoperatively, the patient was satisfied with the results.


Assuntos
Neoplasias Maxilares , Procedimentos de Cirurgia Plástica , Feminino , Humanos , Pessoa de Meia-Idade , Maxila/cirurgia , Maxila/patologia , Qualidade de Vida , Retalhos Cirúrgicos/irrigação sanguínea , Retalhos Cirúrgicos/patologia , Retalhos Cirúrgicos/cirurgia , Antebraço/patologia , Antebraço/cirurgia , Neoplasias Maxilares/cirurgia , Neoplasias Maxilares/patologia
10.
Gan To Kagaku Ryoho ; 49(13): 1758-1761, 2022 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-36732990

RESUMO

In April 2020, a state of emergency was declared because of the pandemic, and the public was instructed to refrain from leaving their homes. Consequently, this stirred up anxiety about visiting medical institutions. Here, we describe a case of tongue carcinoma that developed from an oral precancerous lesion into a malignant transformation owing to the effects of refraining from medical examinations caused by the pandemic. The patient was a 62-year-old woman. In March 2020, the patient became aware of a mass at the tongue's margin and was referred to our department. An excisional biopsy was performed, and a diagnosis of inflammatory change was made. The following month, a white ulcerative lesion was found, and another excisional biopsy was performed; therefore, a diagnosis of left tongue leukoplakia without epithelial dysplasia was made. The patient was scheduled for surgery; however, refused treatment and consultation because of the pandemic. In September 2021, the patient revisited our department on her own volition because an ulcerative lesion with indistinct borders and induration was found at the left lingual margin. Upon close examination, a diagnosis of left tongue squamous cell carcinoma(cT2N2bM0, Stage ⅣA)was made. In October 2021, radical tumor resection and reconstruction were performed. After 8 months postoperatively, the patient is currently well.


Assuntos
Carcinoma de Células Escamosas , Neoplasias da Língua , Humanos , Feminino , Pessoa de Meia-Idade , Neoplasias da Língua/cirurgia , Neoplasias da Língua/patologia , Carcinoma de Células Escamosas/cirurgia , Pandemias , Língua/patologia , Leucoplasia Oral
11.
Gan To Kagaku Ryoho ; 49(13): 1655-1658, 2022 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-36733166

RESUMO

We report a case of advanced lower gingival carcinoma treated with a computer-assisted custom-made surgical guide and reconstruction plate system(TruMatch®)in combination with a pectoralis major myocutaneous flap. In a 74-year-old male patient, a neoplastic lesion with a 30×30 mm periapical induration was observed around an extraction socket of left mandibular third molar. After various examinations, we diagnosed lower gingival carcinoma(cT4aN2bM0, Stage ⅣA). The patient was a paraplegic with a spinal cord injury, and reconstruction of mandible with free flap was not indicated, requiring minimally invasive surgery. Therefore, a surgical guide and reconstruction plate were prepared preoperatively using the Tru- Match® system. Under general anesthesia, the patient underwent tracheostomy, left modified radical neck dissection, segmental mandibulectomy, and reconstruction of the mandible using this system in combination with a pectoralis major myocutaneous flap. Postoperatively, the patient had minimal dysfunction. Currently, at 18 months follow up postoperatively, good prognosis was observed. In conclusion, this is a useful surgical system with accurate and less invasive surgery for segmental mandibulectomy of advanced lower gingival carcinoma.


Assuntos
Neoplasias Ósseas , Carcinoma , Neoplasias Gengivais , Reconstrução Mandibular , Procedimentos de Cirurgia Plástica , Masculino , Humanos , Idoso , Neoplasias Gengivais/cirurgia , Retalhos Cirúrgicos/cirurgia , Mandíbula/cirurgia , Carcinoma/cirurgia , Neoplasias Ósseas/cirurgia , Computadores
12.
Gan To Kagaku Ryoho ; 48(13): 1721-1724, 2021 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-35046309

RESUMO

We report a case of functional recovery following incisional cheiloplasty for the management of lower labial edema that developed after bilateral neck dissection with preservation of the one-side internal jugular vein and postoperative chemoradiotherapy. An 81-year-old woman underwent partial maxillectomy for the treatment of maxillary gingival cancer(squamous cell carcinoma, cT1N0M0, Stage Ⅰ)in April 2013. In July 2013, she underwent bilateral neck dissection(right, modified; left, radical)for bilateral cervical lymph node recurrence with an extra-nodal spread and received postoperative chemoradiotherapy( CDDP 75 mg/m2×3 course and total radiotherapy dosage of 66 Gy). Thereafter, the patient's condition progressed without recurrence or metastasis; however, the lower labium became edematous, and severe labial dysfunction was observed. Therefore, lower labial incisional cheiloplasty was performed under local anesthesia in October 2020. An excision area of 160×14 mm was determined on the inner side of the lower labium, and excision was performed with a steel blade scalpel. Lip closure became possible one week after the operation. Seven months after the operation, the patient recovered labial function and was satisfied with the outcome.


Assuntos
Linfonodos , Esvaziamento Cervical , Idoso de 80 Anos ou mais , Quimiorradioterapia , Edema/etiologia , Edema/terapia , Feminino , Humanos , Metástase Linfática , Recidiva Local de Neoplasia
13.
Gan To Kagaku Ryoho ; 48(13): 2094-2097, 2021 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-35045504

RESUMO

The Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, has been conducting mass screening of oral cancer using oral abrasion cytology by oral surgeons in eastern Shimane prefecture for public awareness and its early detection. As a result, 3(0.09%)cases of oral cancer were identified. Case 1: The patient was diagnosed with well-differentiated squamous cell carcinoma in the floor of the mouth(pT1N0M0, Stage Ⅰ)after undergoing Matsue city oral cancer screening in 2016. Case 2: The patient underwent oral cancer screening in Izumo city in 2018 and was diagnosed with verrucous carcinoma in the back of the tongue(pT1N0M0, Stage Ⅰ). Case 3: The patient was diagnosed with highly differentiated squamous cell carcinoma of the palate(pT1N0M0, Stage Ⅰ)after undergoing the Izumo city oral cancer screening in 2019. Awareness of oral cancer is important, and cancer screening by oral surgeons using cytology is highly useful and should be continued in the future.


Assuntos
Carcinoma de Células Escamosas , Carcinoma Verrucoso , Neoplasias Bucais , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/epidemiologia , Detecção Precoce de Câncer , Humanos , Programas de Rastreamento , Neoplasias Bucais/diagnóstico , Neoplasias Bucais/epidemiologia
14.
Gan To Kagaku Ryoho ; 48(13): 2098-2102, 2021 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-35045505

RESUMO

INTRODUCTION: Pedicled flaps are used in orofacial defect reconstruction in older patients and patients with underlying diseases. The submental island flap(SIF)is one type of cervical pedicled flap; however, the modified submental island flap (MSIF), which includes mylohyoid muscle, is a simpler and safer type. Here, we report a clinical study of orofacial defect reconstruction using the MSIF following oral cancer resection. PATIENTS AND METHODS: From January 2019 to December 2020, we retrospectively examined 10 cases of reconstruction using the MSIF following oral squamous cell carcinoma resection. RESULTS: The study population consisted of 7 men and 3 women with a mean age of 76.0(66-88)years. The primary sites were lower gingiva(n=5), tongue(n=3), and buccal mucosa in(n=2). Surgical procedures included marginal mandibulectomy( n=3), segmental mandibulectomy(n=1), partial glossectomy(n=2), hemiglossectomy(n=1), buccal mucosa resection(n=2), and combined partial glossectomy and segmental mandibulectomy(n=1). The average flap size was 61.4×36.0 mm. The average time of flap elevation was 32.4(23-50)minutes. During orofacial surgery using the MSIF, organs adjacent to the primary site could also be reconstructed. There were no complications in any patients. CONCLUSION: The MSIF is useful for orofacial defect reconstruction in older patients and patients with underlying diseases.


Assuntos
Carcinoma de Células Escamosas , Neoplasias Bucais , Procedimentos de Cirurgia Plástica , Idoso , Carcinoma de Células Escamosas/cirurgia , Feminino , Humanos , Masculino , Neoplasias Bucais/cirurgia , Estudos Retrospectivos , Retalhos Cirúrgicos , Resultado do Tratamento
15.
Gan To Kagaku Ryoho ; 48(13): 1582-1585, 2021 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-35046263

RESUMO

Radical excision, a common oral cancer treatment, produces variable postoperative results depending on the specialized tissues involved and the extent of the cancer. Furthermore, the material selected for reconstruction also influences functional outcomes. Oral dysfunction due to postoperative tissue loss is more common with advanced cancer; therefore, early detection and treatment are important. To improve oral cancer awareness and early detection, mass oral cancer screenings led by maxillofacial surgeons in cooperation with the Shimane prefecture and local dental associations were conducted. We describe the mass screening methods and describe a case of tongue cancer that was detected and treated as a result of our screening efforts.


Assuntos
Carcinoma de Células Escamosas , Neoplasias Bucais , Neoplasias da Língua , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/cirurgia , Detecção Precoce de Câncer , Humanos , Programas de Rastreamento , Neoplasias Bucais/diagnóstico , Neoplasias Bucais/cirurgia , Língua , Neoplasias da Língua/diagnóstico , Neoplasias da Língua/tratamento farmacológico , Neoplasias da Língua/cirurgia
16.
Gan To Kagaku Ryoho ; 47(13): 1820-1823, 2020 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-33468840

RESUMO

Oral leukoplakia is the most common premalignant and potentially malignant lesion of the oral mucosa. Several studies have reported that the prevalence of oral cancer in young people is increasingly rapidly. The patient in this report was a 47- year-old man who complained of left tongue discomfort. At the first visit, the clinical diagnosis was oral leukoplakia, and a follow-up examination was planned with a view to partial resection. However, at the follow-up, biopsy revealed squamous cell carcinoma. He underwent partial resection. Two months after the surgery, metastasis to the lymph node was detected. The patient underwent radical neck dissection and concurrent chemoradiotherapy. At the 3-years follow-up, there was no sign of recurrence or metastasis.


Assuntos
Neoplasias Bucais , Recidiva Local de Neoplasia , Adolescente , Humanos , Leucoplasia Oral , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/cirurgia , Esvaziamento Cervical
17.
Gan To Kagaku Ryoho ; 46(13): 2185-2188, 2019 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-32156873

RESUMO

In recent years, the opportunity to treat oral cancer in elderly patients has been increasing because of the increased lifespan of individuals. Standard treatment for advanced tongue cancer involves reconstruction of the tongue with a free vascularized flap. However, this may not always be suitable for elderly patients because the procedure is lengthy and invasive and also because of their medical history. We report 2 cases of elderly patients undergone oral floor reconstruction with digastric muscle bipedicle flap for advanced tongue cancer. In case 1, an 86-year-old woman underwent pull-through ablation surgery with partial glossectomy and modified radical neck dissection for the treatment of left-sided tongue cancer(well-differentiated squamous cell carcinoma, cT3N2bM0, Stage ⅣA). In case 2, a 93-year-old man underwent pull-through ablation surgery with hemiglossectomy and suprahyoid neck dissection for treatment of right-sided tongue cancer(verrucous carcinoma, cT3N0M0, Stage Ⅲ). In both patients, the flap was sutured to the mandibular border, mandibular periosteum and surrounding tissue, and the intraoral mucosa and neck were isolated. Compared to the reconstruction of the tongue with a free vascularized flap, the procedure used in these 2 cases was shorter and caused less bleeding. Moreover, the patients exhibited no postoperative dysfunction, and clinical outcome remained favorable. We believe that oral floor reconstruction with digastric muscle bipedicle flap at the bottom of the mouth was effective in reducing surgical stress and restoring oral function in very elderly patients.


Assuntos
Procedimentos de Cirurgia Plástica , Neoplasias da Língua , Idoso , Idoso de 80 Anos ou mais , Feminino , Glossectomia , Humanos , Masculino , Esvaziamento Cervical , Retalhos Cirúrgicos , Neoplasias da Língua/cirurgia
18.
Gan To Kagaku Ryoho ; 45(13): 1910-1914, 2018 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-30692395

RESUMO

The pedicled pectoralis major myocutaneous(PMMC)flap, used for the reconstruction of surgical defects in advanced oral cancer resection, is versatile and can be obtained without a highly-invasive procedure. However, flap utility is limited by an unstable blood supply and the relatively high rate of partial necrosis of the skin island. Thus, the use of microvascularized free flaps has become more common in patients requiring oral-maxillofacial reconstruction. Detailed angiographic studies revealed the 3-dimensional vascular anatomy of the PMMC flap. This allowed us to obtain a modified, heart-shaped flap with a skin island that includes the intramuscular vascular networks between the pectoral branches of the thoracoacromial vessels and the intercostal perforators of the internal mammary vessels, thus ensuring a sufficient blood supply and stable survival of the flap. We have used this technique since 2015 to treat 7 patients with locally advanced or recurrent(salvage)oralcancer. None developed critical flap problems, and survival of the total skin island was successfully obtained in all cases. Transfer of the heart-shaped PMMC, including the multiple intercostal perforators from the internal mammary vessels, may contribute to a stable blood supply of the skin island and therefore can be effective for advanced oral cancer reconstruction.


Assuntos
Neoplasias Bucais , Retalho Miocutâneo , Procedimentos de Cirurgia Plástica , Angiografia , Humanos , Neoplasias Bucais/cirurgia , Músculos Peitorais
19.
Gan To Kagaku Ryoho ; 45(13): 1970-1972, 2018 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-30692414

RESUMO

Oral leukoplakia is the most common premalignant or potentially malignant lesion in the oral mucosa. This retrospective study examined 67 lesions from 62 patients with clinical diagnoses of oral leukoplakia who underwent surgical excision in our department from 2015 to 2017. The patients comprised 22 men and 40 women. The most common location of the lesion was the lower gingiva, followed by the tongue, upper gingiva, buccal mucosa, palate, and lip. The most common clinical type was the white-spotted, followed by erythroleukoplakia, hillock, and verrucous types. Histopathologically, 16 lesions were oral intraepithelial neoplasia, whereas five were squamous cell carcinoma. The data identified several characteristics of oral leukoplakia that predict a high risk of malignant transformation and require aggressive surgical resection.


Assuntos
Carcinoma de Células Escamosas , Leucoplasia Oral , Neoplasias Bucais , Carcinoma de Células Escamosas/diagnóstico , Transformação Celular Neoplásica , Feminino , Humanos , Leucoplasia Oral/diagnóstico , Masculino , Mucosa Bucal , Neoplasias Bucais/diagnóstico , Estudos Retrospectivos
20.
J Oral Maxillofac Surg ; 74(10): 2019-32, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27318190

RESUMO

PURPOSE: The retromandibular transparotid approach (RMA) to condylar fractures of the mandible provides excellent access, but can increase the risk of complications. The aim of this study was to estimate the frequency of facial nerve paralysis (FNP) and associated postoperative complications after open reduction and rigid internal fixation (ORIF) of subcondylar fractures through the RMA. MATERIALS AND METHODS: This was a retrospective cohort study of patients with condylar fractures requiring ORIF through the RMA. The inclusion criteria were 1) a medical record of surgical treatment of a subcondylar fracture by RMA; 2) preoperative and postoperative radiographs; 3) mental status permitting an adequate neuromotor examination; 4) absence of a post-injury or pretreatment functional facial nerve deficit; and 5) regular postoperative follow-up longer than 6 months with documentation of complications, functional results, and fixation stability. The predictive variables were age, gender, fracture site, fracture pattern, concomitant fractures, etiology, and plate types. The outcome variable was FNP. Univariate, bivariate, and multiple logistic regression statistics were computed. RESULTS: Fifty patients with 55 displaced mandibular subcondylar fractures (35 men, 15 women; mean age, 44.5 yr; range, 17 to 87 yr) met the inclusion criteria. The condylar fracture involved the neck in 35 patients (63.6%) and the base in 20 patients (36.4%). The fracture pattern was deviation in 11 patients (20.0%), displacement in 23 (41.8%), and dislocation in 21 (38.2%). Precise ORIF with double-buttress fixation resulted in immediate functional recovery in all patients. Seven fractures (12.7%) were associated with FNP that resolved completely within 6 months. Further statistical analysis showed that dislocated and displaced condylar neck fractures were significant risk factors for postoperative FNP (P < .05). Other postoperative complications were minimal. CONCLUSION: The RMA for subcondylar fractures is feasible and safe. Dislocated condylar neck fractures are associated with a highly increased risk of temporary postoperative FNP as a surgical complication.


Assuntos
Traumatismos do Nervo Facial/etiologia , Fixação Interna de Fraturas/métodos , Fraturas Mandibulares/cirurgia , Procedimentos Cirúrgicos Bucais/métodos , Complicações Pós-Operatórias/etiologia , Adulto , Feminino , Humanos , Masculino , Côndilo Mandibular/cirurgia , Pessoa de Meia-Idade , Recuperação de Função Fisiológica , Estudos Retrospectivos
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