Detalhe da pesquisa
1.
Tapcin, an In Vivo Active Dual Topoisomerase I/II Inhibitor Discovered by Synthetic Bioinformatic Natural Product (Syn-BNP)-Coupled Metagenomics.
Angew Chem Int Ed Engl
; 63(17): e202317187, 2024 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38231130
2.
Metagenome-Guided Analogue Synthesis Yields Improved Gram-Negative-Active Albicidin- and Cystobactamid-Type Antibiotics.
Angew Chem Int Ed Engl
; 60(41): 22172-22177, 2021 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34355488
3.
Synthetic-Bioinformatic Natural Product Antibiotics with Diverse Modes of Action.
J Am Chem Soc
; 142(33): 14158-14168, 2020 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32697091
4.
Cadasides, Calcium-Dependent Acidic Lipopeptides from the Soil Metagenome That Are Active against Multidrug-Resistant Bacteria.
J Am Chem Soc
; 141(9): 3910-3919, 2019 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30735616
5.
Urban park soil microbiomes are a rich reservoir of natural product biosynthetic diversity.
Proc Natl Acad Sci U S A
; 113(51): 14811-14816, 2016 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27911822
6.
Discovery of MRSA active antibiotics using primary sequence from the human microbiome.
Nat Chem Biol
; 12(12): 1004-1006, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27748750
7.
Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist.
Proc Natl Acad Sci U S A
; 112(35): E4825-34, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26283367
8.
Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors.
Proc Natl Acad Sci U S A
; 112(14): 4221-6, 2015 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25831524
9.
Antimicrobials Inspired by Nonribosomal Peptide Synthetase Gene Clusters.
J Am Chem Soc
; 139(4): 1404-1407, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28055186
10.
Chemical-biogeographic survey of secondary metabolism in soil.
Proc Natl Acad Sci U S A
; 111(10): 3757-62, 2014 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24550451
11.
Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products.
Proc Natl Acad Sci U S A
; 110(29): 11797-802, 2013 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23824289
12.
Targeted metagenomics: finding rare tryptophan dimer natural products in the environment.
J Am Chem Soc
; 137(18): 6044-52, 2015 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25872030
13.
The chemical arsenal of Burkholderia pseudomallei is essential for pathogenicity.
J Am Chem Soc
; 136(26): 9484-90, 2014 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-24884988
14.
Discovery and synthetic refactoring of tryptophan dimer gene clusters from the environment.
J Am Chem Soc
; 135(47): 17906-12, 2013 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24171465
15.
High-throughput retrieval of target sequences from complex clone libraries using CRISPRi.
Nat Biotechnol
; 41(5): 626-630, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36411313
16.
Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens.
J Am Chem Soc
; 134(32): 13192-5, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22765305
17.
Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis.
Nat Commun
; 13(1): 842, 2022 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35149673
18.
Identification of structurally diverse menaquinone-binding antibiotics with in vivo activity against multidrug-resistant pathogens.
Nat Microbiol
; 7(1): 120-131, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34949828
19.
Multiplexed mobilization and expression of biosynthetic gene clusters.
Nat Commun
; 13(1): 5256, 2022 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36068239
20.
Atolypenes, Tricyclic Bacterial Sesterterpenes Discovered Using a Multiplexed In Vitro Cas9-TAR Gene Cluster Refactoring Approach.
ACS Synth Biol
; 8(1): 109-118, 2019 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30575381