Susceptibility factors to ozone-related mortality: a population-based case-crossover analysis.

RATIONALE: Acute effects of ozone on mortality have been extensively documented in clinical and epidemiological research. However, only a few studies have focused on subgroups of the population especially vulnerable to these effects. OBJECTIVES: To estimate the association between exposure to ozone and cause-specific mortality, and to evaluate whether individual sociodemographic characteristics or chronic conditions confer greater susceptibility to the adverse effects of ozone. METHODS: A case-crossover analysis was conducted in 10 Italian cities. Data on mortality were collected for the period 2001 to 2005 (April-September) for 127,860 deceased subjects. Information was retrieved on cause of death, sociodemographic characteristics, chronic conditions from previous hospital admissions, and location of death. Daily ozone concentrations were collected from background fixed monitors. MEASUREMENTS AND MAIN RESULTS: We estimated a 1.5% (95% confidence interval [CI], 0.9-2.1) increase in total mortality for a 10 microg/m(3) increase in ozone (8-h, lag 0-5). The effect lasted several days for total, cardiac and respiratory mortality (lag 0-5), and it was delayed for cerebrovascular deaths (lag 3-5). In the subgroup analysis, the effect was more pronounced in people older than 85 years of age (3.5%; 95% CI, 2.4-4.6) than in 35- to 64-year-old subjects (0.8%; 95% CI, -0.8 to 2.5), in women (2.2%; 95% CI, 1.4-3.1) than in men (0.8%; 95% CI, -0.1 to 1.8), and for out-of-hospital deaths (2.1%; 95% CI, 1.0-3.2), especially among patients with diabetes (5.5%; 95% CI, 1.4-9.8). CONCLUSIONS: A greater vulnerability of elderly people and women was indicated; subjects who died at home and had diabetes emerged as especially affected.

Particulate matter and out-of-hospital coronary deaths in eight Italian cities.

OBJECTIVES: We evaluated the association between PM(10) concentration and out-of-hospital coronary deaths in eight Italian cities during 1997-2004. METHODS: 16 989 subjects aged >35 years who died out-of-hospital from coronary causes were studied and hospital admissions in the previous 2 years identified. We studied the effect of the mean of current and previous day PM(10) values (lag 0-1). A city-specific case-crossover analysis was applied using a time-stratified approach considering as confounders weather, holidays, influenza epidemics, and summer decrease in population. The pooled percentage increase (95% CI) in mortality per 10 microg/m(3) increase in PM(10) was estimated. RESULTS: A statistically significant increase in out-of-hospital coronary deaths was related to a 10 microg/m(3) increase in PM(10): 1.46% (95% CI 0.50 to 2.43). Although no statistically significant effect modification by age was found, the effect was stronger among subjects aged >65 years (1.60%, 0.59 to 2.63), particularly those aged 65-74 (3.01%, 0.74 to 5.34). People in the lowest socio-economic category (3.34%, 1.28 to 5.45) had a stronger effect than those in the highest category. No clear effect modification was seen for gender, season or any specific comorbidity. An indication of negative effect modification was seen for previous admission for cardiac dysrhythmias. Subjects without hospital admissions in the previous 2 years were slightly more affected by PM(10) effects (1.91%, 0.28 to 3.47) than those with at least one previous hospital admission (1.44%, 0.09 to 2.82). CONCLUSIONS: Our results show that short term exposure to PM(10) is associated with coronary mortality especially among the elderly and socio-economically disadvantaged. No clear effect modification by previous hospitalisations was detected except for cardiac dysrhythmias, possibly due to protective treatment.

[EpiAir health data]. / I dati sanitari nel Progetto EpiAir.

INTRODUCTION: the EpiAir (Air pollution and health: epidemiological surveillance and prevention) Project has been conducted in 10 Italian cities. In this paper we describe the health data used to detect adverse health effects associated with air pollution exposure (mortality and hospital discharge databases) and to identify comorbidities (based on hospital discharge databases) as susceptibility factors to the effects of air pollution. MATERIAL AND METHODS: for each city, we performed descriptive analyses of mortality data included in the study.We considered subjects aged 35+ years old, resident and deceased within the cities in the study period (2001-2005) for non-accidental causes. For each deceased subject, information were collected on hospital discharge diagnoses in the previous 2-year period. Urgent hospital admissions of subjects resident in nine cities and hospitalized within the city for specific diseases (including cardiac, cerebrovascular and respiratory conditions) were also included as endpoints. Annual mean raw death and hospitalization rates were calculated for each city. RESULTS: 276,205 deaths and 701,902 urgent hospital admissions have been included in the study. Annual mean crude death rates for non accidental causes in the population aged +35 yrs resident and deceased in the municipalities ranged from 12.1 and 15.7 per 1,000 residents.The percentage of deceased subjects with at least one of the selected comorbidities ranged from 32 to 48%. Annual mean crude urgent hospitalization rates in the resident population ranged from 5.5 to 11.7 per 1,000 residents for cardiac diseases; 1.7 to 3.7 per 1,000 residents for cerebrovascular diseases and 3.3 to 10.7 per 1,000 residents for respiratory diseases. Several factors can explain the between-cities differences observed, especially in the hospitalization rates, including availability and variability in the health care services utilization. CONCLUSION: an epidemiological surveillance system based on health databases has to take into account the observed differences.

[Air pollution and urgent hospital admissions in nine Italian cities. Results of the EpiAir Project]. / Inquinamento atmosferico e ricoveri ospedalieri urgenti in nine città italiane. Risultati del Progetto EpiAir.

INTRODUCTION: the relationship between air pollution and hospital admissions has been well studied. In this study, the results of the Italian EpiAir Project are reported on the effect of air pollution on hospital admissions in 9 Italian cities during 2001-2005. The association between particulate matter (PM10) and gases (NO2 and O3) and hospital admissions for cardiac, cerebrovascular, respiratory conditions, pulmonary embolism and diabetes has been evaluated. MATERIAL AND METHODS: The study population consists of 701,902 hospital admissions of subjects residents in nine Italian cities and hospitalized in the city in the period 2001- 2005. We used a case-crossover approach and the statistical analysis considered the relevant temporal and meteorological factors for confounding adjustment. The results for ozone refer to the warm semester. The analysis of the association between air pollution and admissions was conducted for each city, and the city-specific estimates were meta-analyzed to obtain pooled results. RESULTS: we found an immediate effect of PM10 and NO2 (lag 0) for cardiac diseases as a group and for specific conditions (coronary syndrome and heart failure). No effect of ozone was observed. For cerebrovascular diseases we did not observe a positive effect of the three pollutants. An effect of NO2 on pulmonary embolism was detected. The association between air pollutants and hospitalization for respiratory diseases (respiratory infections, COPD and asthma) showed different lags for the three pollutants: the effect of PM10 was immediate at lag 0-1 while the effects of NO2 and ozone were prolonged at lag 0-5. The strongest association was between NO2 and asthma admissions, especially in children. No effects on diabetes were found. CONCLUSIONS: the main results of the present study confirm the deleterious short term impact of air pollution on cardiovascular and respiratory morbidity in Italian cities.

[Environmental indicators in ten Italian cities (2001-2005): the air quality data for epidemiological surveillance]. / Indicatori ambientali in dieci città italiane (2001-2005): i dati di qualità dell'aria per la sorveglianza epidemiologica.

OBJECTIVE: to produce environmental indicators suitable for an epidemiological surveillance in 10 Italian cities part of the EpiAir Project (2001-2005). METHODS: the environmental parameters that correlate to relevant health effects are the particles with diameters less than or equal to 10 micrometers (PM10), the nitrogen dioxide (NO2) and the ozone (O3). The necessary meteorological data are: temperature, relative humidity, barometric pressure and apparent temperature.We have identified some criteria to select monitoring stations and have taken standard methods of calculation to produce environmental indicators starting from the daily data available after closely evaluating the completeness of the existing data. Furthermore, we have checked the homogeneity of the selected data to ensure that it represents the population's exposure. RESULTS: close examination of descriptive statistics shows a critical situation of the considered pollutants. The analysis of the yearly state underlines for PM10 values higher than 40 microg/m3 in the area of Mestre-Venice and in Milan, Turin, Bologna e Taranto. For NO2, values are consistently above 40 microg/m3 in Milan, Turin, Bologna, Florence, Rome and Palermo. For ozone, the concentrations were stable, with the exception of Summer 2003 when we recorded, on average, an increase of 13% compared to the mean value estimated for the ten cities during the study period, especially in Mestre-Venice, Turin and Palermo. CONCLUSIONS: it is important to ensure the consistency of the methods and instruments in environmental monitoring. To evaluate health effects and perform interventions over the longterm, it is therefore fundamental that the data be homogenous, especially during the periodic reorganizations and rationalizations of air quality management. It is also necessary to include daily meteorological data that influence pollutant dispersion and population health status.

[Air pollution and mortality in ten Italian cities. Results of the EpiAir Project]. / Inquinamento atmosferico e mortalità in dieci città italiane. Risultati del Progetto EpiAir.

OBJECTIVE: the relationship between air pollution and mortality has been well established in national and international scientific literature. This study reports the results of the EpiAir Project relative to the effect of air pollution on mortality in 10 Italian cities during 2001-2005. The association between particulate matter (PM10) and gases (nitrogen dioxide, NO2, and ozone, O3), and all natural mortality, as well as cardiac, cerebrovascular and respiratory mortality, is presented. Specific issues have been investigated, such as the latency of the air pollution-mortality effects and the identification of individual demographic characteristics and clinical conditions that result in greater susceptibility to the effects of particulate matter. METHODS: the study population consisted of 276,205 subjects aged 35+ years old, resident in one of the 10 Italian cities studied, which died in the city between 2001-2005. For each subject, information was collected on cause of death, location of death, demographical variables and hospital discharge diagnoses in the previous 2-year period. The statistical analysis was adjusted for the relevant temporal and meteorological factors using the case-crossover approach. The results for ozone are limited to the warm semester (April through September). An analysis of the association between air pollution and mortality was conducted for each city, and the city-specific estimates were meta-analyzed on a second level to obtain a pooled result, and reported inter-city heterogeneity. RESULTS: a short-term effect of PM10 on mortality has been detected for all the groups of causes considered, with latencies ranging from lag 0 for cerebrovascular mortality to lag 0-3 for respiratory mortality. The association between NO2 and mortality displays strong and similar effects for all death causes, with prolonged effects (lag 0-5) for all groups of causes. The results for O3 are similar to those found for NO2, with prolonged latency (lag 0-5) for all causes of death with the exception of cerebrovascular mortality, for which a delayed effect (lag 3-5) was identified. Individual susceptibility factors of the PM10-natural mortality association include age, as elderly subjects are especially vulnerable to the effects of particles. CONCLUSIONS: the main results of the study suggest that the air pollution originated by vehicular traffic is the most relevant environmental problem in Italian cities from a public health viewpoint.

Particulate matter and daily mortality: a case-crossover analysis of individual effect modifiers.

BACKGROUND: Several time-series studies have established the relationship between particulate matter (PM10) and mortality. We adopted a case-crossover design to evaluate whether individual socio-demographic characteristics and chronic or acute medical conditions modify the PM10-mortality association. METHODS: We selected all natural deaths (321,024 subjects) occurring among adult (aged 35+ years) residents of 9 Italian cities between 1997 and 2004. We had access to individual information on socio-demographic variables, location of death, and chronic conditions (hospital admissions in the preceding 2-year period). For in-hospital deaths, we collected information on treatment wards at time of death and acute medical conditions. In a case-crossover analysis we adjusted for time, population changes, and meteorological conditions. RESULTS: PM10 was associated with mortality among subjects age 65 years and older (0.75% increase per 10 microg/m3 [95% confidence interval = 0.42% to 1.09%]), with a more pronounced effect among people age 85 and older. A weaker effect was found among the most affluent people. The effect was present for both out-of-hospital and in-hospital deaths, especially among those treated in general medicine and other less specialized wards. PM10 effects were stronger among people with diabetes (1.03% [0.28% to 1.79%]) and chronic obstructive pulmonary disease (0.84% [0.17% to 1.52%]). The acute conditions with the largest effect estimates were acute impairment of pulmonary circulation (4.56% [0.75% to 8.51%]) and heart failure (1.67% [0.30% to 3.04%]). CONCLUSIONS: Several factors, including advanced age, type of hospital ward, and chronic and acute health conditions, modify the PM10-related risk of death. Altered pulmonary circulation and heart failure are important effect modifiers, suggesting that cardiac decompensation is a possible mechanism of the fatal PM10 effect.

[Ischemic heart disease prevalence estimated using a standard algorithm based on electronic health data in various areas of Italy]. / Stima della prevalenza della cardiopatia ischemica basata su dati sanitari correnti mediante un algoritmo comune in differenti aree italiane.

AIM: to define an algorithm to estimate prevalence of ischemic heart disease from health administrative datasets. SETTING: four Italian areas: Venezia, Treviso, Torino, Firenze. PARTICIPANTS: resident population in the four areas in the period 2002-2004 (only 2003 for Firenze) for a total of 2,350,000 inhabitants in 2003. MAIN OUTCOMES: annual crude and standardized prevalence rate (x100 inhabitants), 95% confidence intervals by area. Quality (comparability and coherence) indicators are also reported METHODS: the algorithm is based on record linkage of hospital discharges (SDO), pharmacological prescriptions (PF), exemptions from health-tax exemptions (ET) and causes of mortality (CM). From SDO we extracted discharges for ICD9-CM codes 410*-414* in all diagnoses in the estimation year and during the four years immediately preceding. We selected from PF subjects with at least two prescriptions of organic nitrates (ATC = C01DA*) in the estimation year. From ET subjects with a new exemption for ischemic heart disease (002.414) or who obtained exemption in the three years preceding, were selected. We also considered all deaths in the year for ischemic heart disease (ICD9 CM 410-414). Cases were defined as ischemic heart disease prevalent cases if they were extracted at least once from one of the datasets and if they were alive on January 1 of the estimation year. RESULTS: estimated crude prevalence ranges from 2.5 to 4%. The standardized prevalence led to a narrower range of values (2.8-3.3%). Venezia and Firenze show a higher standardized prevalence in both sexes (men 4.7% and 4.4%; women 2.3% and 2.2% respectively); Treviso and Torino present a lower standardized prevalence (men: 3.9%; women: 1.9%). The hospital discharges are the main source to identify prevalent subjects (34-48% of subjects are solely identified by SDO), pharmacological prescriptions are a relevant source in Firenze and Torino (27-28%), while they are less relevant in Venezia and Treviso (13-15%). ET shows a different contribution to prevalent case identification in the four areas: Venezia (8%), Treviso (3.2%), Firenze (1.3%), whereas in Torino this source was not available at all. Subjects classified as prevalent cases only through causes of death are less than 2%. The percentage of subjects simultaneously identified by multiple sources is high in Venezia (43%) and low in Torino (30%). CONCLUSIONS: patterns in use of pharmaceuticals and exemptions from prescription charges appear to be heterogeneous in the different areas under study. These two aspects make a proper comparison between areas difficult. The algorithm could be applied only in areas with a similar use of organic nitrates and with a good comparability of the exemptions dataset.

[Acute stroke incidence estimated using a standard algorithm based on electronic health data in various areas of Italy]. / Stima dell'incidenza di ictus acuto basata su dati sanitari correnti mediante un algoritmo comune in differenti aree italiane.

AIM: to define an algorithm and implement it in various areas of Italy, in order to evaluate acute stroke incidence through current databases. SETTING: Lazio, Tuscana , Venezia AULSS 12, Torino ASL 5. PARTICIPANTS: resident-based population in the above mentioned 4 areas during 2002-2004. MAIN OUTCOME: Annual and triennal incidence rate (crude and standardized per 100,000 inhabitants with 95% CI) by sex and age classes (0-14, 15-34, 35-54, 55-64, 65-74, 75-84, 85+), standardized rate of mortality by sex and areas. METHODS: acute stroke incident cases during 2002-2004 in the 4 Italian areas were identified through hospitalization databases (SDO) and death causes (CM). The selection was made including hospitalization cases (no outpatients) and deceased people with a discharge or death code ICD9-CM 430*, 431*, 434*, 436* with no hospitalization for stroke diagnosis in the previous 60 months. Moreover, patients with 438* codes in secondary diagnoses and patients with hospital discharge from rehabilitation or long-hospital units were excluded. RESULTS: men have a higher crude incidence rate than women (+30%). The age-specific rates show a large variability among the areas for elderly people (65+ for men and 75+ for women), with higher rates in Toscana in both genders (cases per 100,000 inhabitants: 260.1 men; 193.1 women). Intermediate values were found in Torino and in Lazio; the lowest values are reported in Venezia (men: 182.5; women: 1368). Standardized mortality rates also present higher mortality levels in the two regional areas (Lazio and Toscana) and lower levels in the two urban areas (Torino and Venezia). CONCLUSIONS: It is not easy to evaluate the algorithm. Results seem compatible enough with other studies and show a certain consistency with current mortality data. Different socio-economical characteristics could account for differences in the estimated incidence among areas. However, diferences in the quality indicators suggest that a validation study with standardized diagnostic criteria will make quality evaluation of the algorithm possible.

[Asthma prevalence estimated using a standard algorithm based on electronic health data in various areas of Italy]. / Stima della prevalenza dell'asma bronchiale basata su dati sanitari correnti mediante un algoritmo comune in differenti aree italiane.

AIM: development of an algorithm to estimate asthma prevalence by record linkage of different health databases: causes of death (CM), hospital discharges (SDO), drug prescriptions archive (PF), health tax exemptions (ET) in three Italian areas. SETTING: Venezia AULSS 12, city of Torino, Firenze ASL 10. PARTICIPANTS: residents aged between 0 and 34 years in the above three centres in the three year period 2002-2004, for a total of 661,275 inhabitants on 30 June 2003. MAIN OUTCOME: annual crude and standardized prevalence (per 100 inhabitants) with 95% confidence intervals by gender and age groups (0-14, 15-34, total: 0-34 years). METHODS: for each year of interest, we selected the following: cases with asthma as primary cause of death from CM; all persons discharged from hospitals with diagnosis (primary or secondary) of asthma (ICD9-CM code = 493*); selected prescriptions of anti-asthma drugs (ATC code = R03A, R03CC02, R03CC04, R03CK, R03DC01, R03DC03), and health-tax exemptions for asthma (code = 007.493) from ET. We defined as prevalent case a subject who was present every single year in at least one of four health databases. We reported the absolute and relative contribution of each information system by area, age, gender and year of interest. A sensitivity analysis using more restrictive criteria to identify prevalent cases (two or more prescriptions per year) was also performed. RESULTS: the PF archive is the most important information source in identifying prevalent cases (from 92.5% of Torino to 95.4% of Firenze). The standardized prevalence of asthma in 0-34 years of age is higher in Venezia (6.37%; 2003 year) than in the other two areas, which show similar values (4.01% in Firenze, 3.77% in Torino; 2003 year). In both genders, the standardized prevalence of asthma is, for all centers, clearly higher in the 0-14 age group than in the 15-34 age group. However, Venezia has a prevalence almost twice (11.21%) that of Firenze (6.20%) and Torino (5.60%) in the 0-14years age group. The use of more restrictive criteria in case identification consistently reduces the estimated prevalence; however, in the 0-14 age group the prevalence estimated in Venice (3.3%) is still almost twice as high as those observed in the other centres (1.8% in Florence and 1.6% in Turin). CONCLUSIONS: the algorithm used to estimate asthma prevalence in the 0-34 years age group provides values which differ considerably between the centres that contributed to the study. A validation study is required to evaluate the diagnostic quality of the identified cases, in particular among younger subjects.

[Obstructive lung disease prevalence estimated using a standard algorithm based on electronic health data in various areas of Italy]. / Stima della prevalenza di malattie polmonari cronico-ostruttive basata su dati sanitari correnti mediante un algoritmo comune in differenti aree italiane.

OBJECTIVE: development of an algorithm to estimate the prevalence of obstructive lung diseases (OLD) through record linkage of administrative health data sources in three Italian areas. SETTING: AULSS 12 Veneziana, city of Torino, ASL10 Firenze. PARTICIPANTS: all residents in the three areas in the period 2002-2004 (N = 1,944,471 on 30th June 2003). MAIN OUTCOME: crude prevalence, standardized prevalence with 95% confidence intervals. METHODS: the following data sources were used to identify OLD cases: hospital discharges (HD), health-tax exemptions (HTE), death causes (DC) and drug prescriptions (DP). All patients diagnosed with (from HD) or dead because of chronic bronchitis, emphysema and asthma have been included in the analysis. We defined as a prevalent case a subject found in each year in at least one of the four data sources. We reported the absolute and relative contribution of each information system by area, age, gender and year of interest. We performed a sensitivity analysis using more restrictive criteria to identify prevalent cases (two or more DPs per year). RESULTS: DP was the most relevantsource in identifying cases (from 86 to 88%). The relative contribution ofHD ranged from 3 to 5%. In 2003, standardized prevalence of OLD ranged from 5.35% in Firenze to 6.02% in Venezia. Venezia showed a higher prevalence in children aged 0-14years and a lower prevalence in older age groups (> 64 years) compared to other centers. Overall, the prevalence was higher among males. The use of more restrictive criteria in case identification substantially reduces the estimated prevalence, particularly in younger age-groups and to a lesser extent, in older age-groups. CONCLUSIONS: the algorithm provides estimates with differences between centres. The validity of this algorithm (in terms of sensitivity and positive predictive value) needs to be evaluated through further ad hoc studies.

[Diabetes prevalence estimated using a standard algorithm based on electronic health data in various areas of Italy]. / Stima della prevalenza di diabete basata su dati sanitari correnti mediante un algoritmo comune in differenti aree italiane.

AIMS: the goal of this study was to estimate the prevalence of diabetes through record linkage of various data sources in four Italian areas. SETTING: Aulss 12 Veneziana, Aulss 4 Alto vicentino, Torino, ASL10 of Firenze. PARTICIPANTS: all 2002 to 2004 residents in the four areas (n = 2,123,913 on 30th June 2003). MAIN OUTCOME: crude prevalence by age and gender and standardized prevalence by gender. METHODS: we used three different data sources. The first was the set of files of all persons discharged from hospitals with a primary or secondary diagnosis of diabetes (ICD-9-CM code 250*) in the year of interest or in the four previous years. The second data source was the set of files of all prescriptions of antidiabetic drugs (ATC code: A10A* and A10B*) prescribed in the year of interest; we considered as persons with diabetes only those who had at least two prescriptions of antidiabetic drugs at two different times. The third source was the set of files of all subjects who obtained exemption from payment of drugs or laboratory testing due to a diagnosis of diabetes mellitus in the year of interest or in the 3 previous years. All data sources were matched by a deterministic linkage procedure. We defined as "prevalent case" those persons who were present in at least one of the three data sources. We compared the estimated prevalence in the four different areas. RESULTS: in 2003, the prevalence of diabetes in the four areas ranged from 3.93% to 5.55% among men, and from 3.55% to 4.52% among women. After adjustment for age, differences among men were reduced and were no longer present among women. Prevalence is higher among the elderly and among men. CONCLUSIONS: using routinely collected data we were able to identify large cohorts of persons with known diabetes and to estimate the prevalence of the disease, which was shown to be highly homogeneous among participating centres, and similar to that reported in other studies conducted in Italy with more costly and time consuming methods.

[Acute myocardial infarction incidence estimated using a standard algorithm based on electronic health data in different areas of Italy]. / Stima dell'incidenza dell'infarto miocardico acuto basata su dati sanitari correnti mediante un algoritmo comune in differenti aree italiane.

AIM: to define and implement an algorithm, based on current databases, in order to estimate acute myocardial infarction (AMI) incidence in six Italian areas. SETTING: Local Health Units of Firenze and Venezia, and the municipalities of Pisa, Roma, Taranto, and Torino. PARTICIPANTS: residents in the above mentioned six areas in the period 2002-2004, for a total of about 4,447,000 subjects (30th June 2003). METHODS: acute myocardial infarction incident cases were identified through hospitalization databases and causes of death. Hospital discharges (excluding outpatient discharges) with ICD9-CM code 410* as primary discharge diagnosis, or as secondary diagnosis when associated with selected codes suggestive of ischemic symptoms in primary diagnosis, and deaths with the ICD9-CM code 410* as underlying cause were selected. Patients without a previous hospitalization for ICD9-CM codes 410* and 412* during the previous 60 months were considered as incident cases. Crude, age-specific and age-standardized incidence rates (standard: total Italian population at the 2001 census) were calculated. A number of data quality indicators were also evaluated. RESULTS: age-standardized incidence rates show different levels of incidence in the areas included in the study. Both for males and females, higher incidence is observed in Rome and Turin (males: respectively 260.5 and 260.2 cases/100,000; females: 105.6 cases/100,000 in both areas). The lowest incidence is observed in Taranto (males: 219.5 cases/100,000; females: 87.0 cases/100,000). Quality indicators suggest a good comparability of incidence estimates among the studied areas. In particular, in both genders, the differences observed in the incidence rates are consistent with the differences of current AMI mortality rates. CONCLUSIONS: although limitations in data comparability among the studied areas and in the quality of disease coding cannot be completely excluded, results suggest that the algorithm we used provides estimates of AMI incidence rates comparable among the studied areas. Only a validation study with standardized criteria will make it possible to more closely evaluate the diagnostic quality and comparability of AMI cases identified through this algorithm.

[Chronic obstructive pulmonary disease prevalence estimated using a standard algorithm based on electronic health data in various areas of Italy]. / Stima della prevalenza di broncopneumopatia cronico-ostruttiva basata su dati sanitari correnti, mediante l'uso di un algoritmo comune, in differenti aree italiane.

AIM: to estimate the prevalence of chronic obstructive pulmonary disease (COPD) by integrating various administrative health information systems. METHODS: prevalent COPD cases were defined as those reported in the hospital discharge registry (HDR) and cause of mortality registry (CMR) with codes 490*, 491*, 492*, 494* and 496* of the International diseases classification 9th revision. Annual prevalence was estimated in 35+ year-old residents in six Italian areas ofb different sizes, in the period 2002-2004. We included cases observed in the previous four years who were alive at the beginning of each year. RESULTS: in 2003, age-standardized prevalence rates varied from 1.6% in Venice to 5% in Taranto. Prevalence was higher in males and increased with age. The highest rates were observed in central (Rome) and southern (Taranto) cities, especially in the 35-64 age group. HDR contributed 91% of cases. Health-tax exemption registry would increase the prevalence estimate by 0.2% if used as a third data source. CONCLUSIONS: with respect to the National Health Status survey, COPD prevalence is underestimated by 1%-3%; this can partly be due to the selection of severe and exacerbated COPD by the algorithm used. However, age, gender and geographical characteristics of prevalent cases were comparable to national estimates. Including cases observed in previous years (longitudinal estimates) increased the point estimate (yearly) of prevalence two or three times in each area.

[Objectives, tools and methods for an epidemiological use of electronic health archives in various areas of Italy]. / Obiettivi, strumenti e metodi per un utilizzo epidemiologico di archivi sanitari elettronici correnti in diverse aree italiane.

The availability of Electronic Health Archives (EHA) has increased remarkably over the last twenty years. As part of a joint project of the Italian Association of Epidemiology (AIE) and the Italian Association of Medical Statistics and Clinical Epidemiology (SISMEC), a workgroup of experts was set up in 2005 with the aim of comparing various experiences and of standardizing the procedures by which electronic sources can be integrated. In particular, the workgroup's aim was to estimate the frequency of certain major diseases using standard algorithms applied to EHA. This volume is published with the purpose of making available in a common publication the methods and the results obtained. The results from a multicentre study using a standard approach to probabilistic record-linkage procedures are also included in a specific chapter. Eleven Italian centres from five Italian regions with an overall population of 11,932,026 collected and treated more than 21,374,426 records (year 2003) from five electronic information sources: death certificates, hospital discharge records (including outpatient discharges), drug prescriptions, tax- exemptions, and pathology records in order to estimate the frequency of the following diseases: diabetes, ischemic heart diseases, acute myocardial infarction, stroke, asthma, chronic obstructive pulmonary disease, obstructive lung diseases. For each pathology a specific algorithm was developed and used by all centres for the identification of the prevalent/incident cases of the selected diseases. Standardized methods were used to estimate the rates. The results confirm the need for a common standard approach to produce estimates based on EHA, considering the variability of the quality and of the completeness of the archives, and the difficulties of standardizing record-linkage operations in the various centres. The main achievement of this work was the elimination of the variability due to the use of different algorithms to identify cases using EHA.

[End-of-life medical decisions: study of physician's opinions in four Italian centres]. / Decisioni mediche di fine vita: uno studio sulle opinioni dei medici in quattro aree italiane.

OBJECTIVE: Knowing the physicians' opinions on end-of-life decisions. DESIGN: In 2002, in the context of an European collaborative study (EURELD) a structured questionnaire has been sent to the physicians of the 9 specialties mostly involved in the assistance of terminal patients. The questionnaire asked to express an opinion on 13 statements on end-of-life decisions and to express his/her intention to behave about 4 hypothetical clinical cases. SETTING: four Italian centres: Florence-Prato, Venice, Trento and Bologna. PARTICIPANTS: 1508 questionnaires were studied, the response rate ranged between 34% (Firenze) to 50% (Trento). RESULTS: In the univariate analysis, there were no significant differences between centres for the 13 statements on end-of-life decisions. In all centres, about one third physicians accepted euthanasia; about one half supported advance directives whereas most physicians would have withheld treatment on the request of patient or intensified the alleviation of symptom and pain. The intended behaviours of withholding treatment, intensifying the alleviation of pain/symptoms, euthanasia, deep sedation until death were more frequently expressed in case of the request of patient than on the physicians own initiative or on request of the family CONCLUSION: The physicians' attitudes were homogeneous between the various centers and they may well be representative of the phenomenon which has been investigated, at least in Northern-Central Italy.

[Environmental pollution from dioxins and soft tissue sarcomas in the population of Venice and Mestre: an example of the use of current electronic information sources]. / Indagine su inquinamento ambientale da diossine e sarcomi dei tessuti molli nella popolazione di Venezia e Mestre: un esempio di utilizzo di fonti informative elettroniche correnti.

OBJECTIVE: Estimating the potential carcinogenic risk associated with exposure to dioxins generated by industrial emissions and urban incinerators. DESIGN: We conducted a geographical investigation on the relationship between Soft Tissue Sarcomas (STS) and other tumours, and estimated levels of exposures to dioxins. Estimates ofthe population's exposure were derived from a historical analysis of emissions of dioxins and other pollutants, conducted by the Province of Venice in all the Venetian area in 1980-1990. Cancer cases were selected from two electronic pathology databases of Venice and Mestre, computerized since 1987. All STS diagnoses were revised in order to improve the quality of the cases in the study and cases of Kaposi sarcoma were excluded from the analysis. The 198 remaining STS--Hodgkin's lymphoma, non-Hodgkin' lymphoma and subjects with at least one cancer--were linked to the registry of residents and mapped according to the pollutant level estimates using GIS techniques. The same procedure was applied to cases of non-Hodgkin's lymphoma (n=822), Hodgkin's lymphoma (n=142) and to 25.568 cases of all cancer at other sites, with microscopic confirmation for comparison. SETTING: Venetian AULSS 12. RESULTS: Risks for STS (measured as Standardized Incidence Ratios SIR) did not show any trend related to categories of dioxin pollution. Among women, a statistically significant increased SIR of 1.69 was estimated for the highest category of exposure. The corresponding SIR for Hodgkins lymphoma was 1.94 (I.C. 1.08-1.19). No major excesses were estimated for other cancer sites. CONCLUSION: Overall, no consistent association between cancer risk and estimated exposure to dioxins was detected in the population under study However, a statistically significant excess of STS among women in the highest exposure category allows for the possibility of a role of environmental exposure.

[Epidemiological investigation on the health status of employees in two factories manufacturing and repairing railway rolling stock: a historical perspective study of mortality]. / Indagine epidemiologica sullo stato di salute degli addetti alla produzione e riparazione carrozze ferroviarie: uno studio prospettico storico di mortalità.

BACKGROUND: Epidemiological studies of cancer risk due to occupational exposure to asbestos in production and repair of railway rolling stock has so far given consistent results for mesothelioma, but conflicting evidence for lung cancer. OBJECTIVES: The main purpose of this study was to investigate risk for mesothelioma and lung cancer in relation to estimated patterns of exposure in the occupational environment of railway rolling stock manufacture and repair. METHODS: A historical prospective study approach was adopted. The mortality experience of the study population was compared to that of the population of the Veneto Region. Two historical cohorts of workers employed in two plants manufacturing and repairing railway coaches were followed up for mortality. A total of 1,621 workers were enrolled in the study from the first factory, and 1,190 from the second. RESULTS: An elevation of both pleural mesothelioma and lung cancer was reported in the two factories with SMRs of 21.52 (CI 95%=1.64-32.29) and 6.46 (CI 95%=1.33-18.88), and 1.26 (CI 95%=1.01-1.54) and 1.18 (CI 95%=0.81-1.66) respectively. The two excesses however showed different patterns in relation to historical exposure estimates, which appear to correlate with mesotheliomas but not with lung cancer. An elevation of mortality for non-neoplastic respiratory diseases was associated with employment during periods when it was estimated that exposure was at higher levels in one of the two firms. CONCLUSIONS: The results confirm the high carcinogenic risk deriving from asbestos exposure, although inconsistencies were found between target organs in relation to exposure estimates, and the existence of time periods in production in which cancer risk was different.

No evidence of increased risk of soft tissue sarcomas in the neighborhood of a steel foundry in Verona.

The aim of the present study was to evaluate the possible association between occurrence of soft tissue sarcomas in Verona (Italy) and residence near a steel foundry, whose emissions of dioxin-like compounds may be relevant. Exposure to total suspended particulate (TSP) emitted from the plant as estimated by ADMS-urban dispersion model was used as an indirect index of exposure to dioxin-like compounds. Verona municipality was divided in six subareas according to the decreasing levels of estimated TSP exposure, and soft tissue sarcomas cases were mapped according to residence at time of diagnosis. Standardized incidence ratios were computed. No statistically significant departures between observed and expected cases were detected as illustrated by trend-test results.