Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

An altered extracellular matrix-integrin interface contributes to Huntington's disease-associated CNS dysfunction in glial and vascular cells.

Hernandez, Sarah J; Lim, Ryan G; Onur, Tarik; Dane, Mark A; Smith, Rebecca; Wang, Keona; Jean, Grace En-Hway; Reyes-Ortiz, Andrea; Devlin, Kaylyn; Miramontes, Ricardo; Wu, Jie; Casale, Malcolm; Kilburn, David; Heiser, Laura M; Korkola, James E; Van Vactor, David; Botas, Juan; Thompson-Peer, Katherine L; Thompson, Leslie M.

Hum Mol Genet ; 32(9): 1483-1496, 2023 04 20.

Artigo em Inglês | MEDLINE | ID: mdl-36547263

2.

BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease.

Gu, Yingli; Pope, Alexander; Smith, Charlene; Carmona, Christopher; Johnstone, Aaron; Shi, Linda; Chen, Xuqiao; Santos, Sarai; Bacon-Brenes, Claire Cecile; Shoff, Thomas; Kleczko, Korbin M; Frydman, Judith; Thompson, Leslie M; Mobley, William C; Wu, Chengbiao.

Neurobiol Dis ; 195: 106502, 2024 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-38608784

3.

Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins.

Fote, Gianna M; Geller, Nicolette R; Efstathiou, Nikolaos E; Hendricks, Nathan; Vavvas, Demetrios G; Reidling, Jack C; Thompson, Leslie M; Steffan, Joan S.

J Cell Sci ; 135(2)2022 01 15.

Artigo em Inglês | MEDLINE | ID: mdl-34982109

4.

Transplanted human neural stem cells rescue phenotypes in zQ175 Huntington's disease mice and innervate the striatum.

Holley, Sandra M; Reidling, Jack C; Cepeda, Carlos; Wu, Jie; Lim, Ryan G; Lau, Alice; Moore, Cindy; Miramontes, Ricardo; Fury, Brian; Orellana, Iliana; Neel, Michael; Coleal-Bergum, Dane; Monuki, Edwin S; Bauer, Gerhard; Meshul, Charles K; Levine, Michael S; Thompson, Leslie M.

Mol Ther ; 31(12): 3545-3563, 2023 Dec 06.

Artigo em Inglês | MEDLINE | ID: mdl-37807512

5.

PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease.

Morozko, Eva L; Smith-Geater, Charlene; Monteys, Alejandro Mas; Pradhan, Subrata; Lim, Ryan G; Langfelder, Peter; Kachemov, Marketta; Kulkarni, Jayesh A; Zaifman, Josh; Hill, Austin; Stocksdale, Jennifer T; Cullis, Pieter R; Wu, Jie; Ochaba, Joseph; Miramontes, Ricardo; Chakraborty, Anirban; Hazra, Tapas K; Lau, Alice; St-Cyr, Sophie; Orellana, Iliana; Kopan, Lexi; Wang, Keona Q; Yeung, Sylvia; Leavitt, Blair R; Reidling, Jack C; Yang, X William; Steffan, Joan S; Davidson, Beverly L; Sarkar, Partha S; Thompson, Leslie M.

Proc Natl Acad Sci U S A ; 118(4)2021 01 26.

Artigo em Inglês | MEDLINE | ID: mdl-33468657

6.

Microglia Do Not Restrict SARS-CoV-2 Replication following Infection of the Central Nervous System of K18-Human ACE2 Transgenic Mice.

Olivarria, Gema M; Cheng, Yuting; Furman, Susana; Pachow, Collin; Hohsfield, Lindsay A; Smith-Geater, Charlene; Miramontes, Ricardo; Wu, Jie; Burns, Mara S; Tsourmas, Kate I; Stocksdale, Jennifer; Manlapaz, Cynthia; Yong, William H; Teijaro, John; Edwards, Robert; Green, Kim N; Thompson, Leslie M; Lane, Thomas E.

J Virol ; 96(4): e0196921, 2022 02 23.

Artigo em Inglês | MEDLINE | ID: mdl-34935438

7.

Translating cell therapies for neurodegenerative diseases: Huntington's disease as a model disorder.

Rosser, Anne E; Busse, Monica E; Gray, William P; Badin, Romina Aron; Perrier, Anselme L; Wheelock, Vicki; Cozzi, Emanuele; Martin, Unai Perpiña; Salado-Manzano, Cristina; Mills, Laura J; Drew, Cheney; Goldman, Steven A; Canals, Josep M; Thompson, Leslie M.

Brain ; 145(5): 1584-1597, 2022 06 03.

Artigo em Inglês | MEDLINE | ID: mdl-35262656

8.

Treatment with JQ1, a BET bromodomain inhibitor, is selectively detrimental to R6/2 Huntington's disease mice.

Kedaigle, Amanda J; Reidling, Jack C; Lim, Ryan G; Adam, Miriam; Wu, Jie; Wassie, Brook; Stocksdale, Jennifer T; Casale, Malcolm S; Fraenkel, Ernest; Thompson, Leslie M.

Hum Mol Genet ; 29(2): 202-215, 2020 01 15.

Artigo em Inglês | MEDLINE | ID: mdl-31696228

9.

IKKß slows Huntington's disease progression in R6/1 mice.

Ochaba, Joseph; Fote, Gianna; Kachemov, Marketta; Thein, Soe; Yeung, Sylvia Y; Lau, Alice L; Hernandez, Sarah; Lim, Ryan G; Casale, Malcolm; Neel, Michael J; Monuki, Edwin S; Reidling, Jack; Housman, David E; Thompson, Leslie M; Steffan, Joan S.

Proc Natl Acad Sci U S A ; 116(22): 10952-10961, 2019 05 28.

Artigo em Inglês | MEDLINE | ID: mdl-31088970

10.

Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease.

Crapser, Joshua D; Ochaba, Joseph; Soni, Neelakshi; Reidling, Jack C; Thompson, Leslie M; Green, Kim N.

Brain ; 143(1): 266-288, 2020 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-31848580

11.

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.

Quinti, Luisa; Dayalan Naidu, Sharadha; Träger, Ulrike; Chen, Xiqun; Kegel-Gleason, Kimberly; Llères, David; Connolly, Colúm; Chopra, Vanita; Low, Cho; Moniot, Sébastien; Sapp, Ellen; Tousley, Adelaide R; Vodicka, Petr; Van Kanegan, Michael J; Kaltenbach, Linda S; Crawford, Lisa A; Fuszard, Matthew; Higgins, Maureen; Miller, James R C; Farmer, Ruth E; Potluri, Vijay; Samajdar, Susanta; Meisel, Lisa; Zhang, Ningzhe; Snyder, Andrew; Stein, Ross; Hersch, Steven M; Ellerby, Lisa M; Weerapana, Eranthie; Schwarzschild, Michael A; Steegborn, Clemens; Leavitt, Blair R; Degterev, Alexei; Tabrizi, Sarah J; Lo, Donald C; DiFiglia, Marian; Thompson, Leslie M; Dinkova-Kostova, Albena T; Kazantsev, Aleksey G.

Proc Natl Acad Sci U S A ; 114(23): E4676-E4685, 2017 06 06.

Artigo em Inglês | MEDLINE | ID: mdl-28533375

12.

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease.

Zhao, Xiaobei; Chen, Xu-Qiao; Han, Eugene; Hu, Yue; Paik, Paul; Ding, Zhiyong; Overman, Julia; Lau, Alice L; Shahmoradian, Sarah H; Chiu, Wah; Thompson, Leslie M; Wu, Chengbiao; Mobley, William C.

Proc Natl Acad Sci U S A ; 113(38): E5655-64, 2016 09 20.

Artigo em Inglês | MEDLINE | ID: mdl-27601642

13.

The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.

Wang, Bo; Zeng, Li; Merillat, Sean A; Fischer, Svetlana; Ochaba, Joseph; Thompson, Leslie M; Barmada, Sami J; Scaglione, Kenneth M; Paulson, Henry L.

Neurobiol Dis ; 109(Pt A): 127-136, 2018 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-28986324

14.

Potential function for the Huntingtin protein as a scaffold for selective autophagy.

Ochaba, Joseph; Lukacsovich, Tamás; Csikos, George; Zheng, Shuqiu; Margulis, Julia; Salazar, Lisa; Mao, Kai; Lau, Alice L; Yeung, Sylvia Y; Humbert, Sandrine; Saudou, Frédéric; Klionsky, Daniel J; Finkbeiner, Steven; Zeitlin, Scott O; Marsh, J Lawrence; Housman, David E; Thompson, Leslie M; Steffan, Joan S.

Proc Natl Acad Sci U S A ; 111(47): 16889-94, 2014 Nov 25.

Artigo em Inglês | MEDLINE | ID: mdl-25385587

15.

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes.

Sontag, Emily M; Joachimiak, Lukasz A; Tan, Zhiqun; Tomlinson, Anthony; Housman, David E; Glabe, Charles G; Potkin, Steven G; Frydman, Judith; Thompson, Leslie M.

Proc Natl Acad Sci U S A ; 110(8): 3077-82, 2013 Feb 19.

Artigo em Inglês | MEDLINE | ID: mdl-23365139

16.

Targeting H3K4 trimethylation in Huntington disease.

Vashishtha, Malini; Ng, Christopher W; Yildirim, Ferah; Gipson, Theresa A; Kratter, Ian H; Bodai, Laszlo; Song, Wan; Lau, Alice; Labadorf, Adam; Vogel-Ciernia, Annie; Troncosco, Juan; Ross, Christopher A; Bates, Gillian P; Krainc, Dimitri; Sadri-Vakili, Ghazaleh; Finkbeiner, Steven; Marsh, J Lawrence; Housman, David E; Fraenkel, Ernest; Thompson, Leslie M.

Proc Natl Acad Sci U S A ; 110(32): E3027-36, 2013 Aug 06.

Artigo em Inglês | MEDLINE | ID: mdl-23872847

17.

A short note for Mike.

Thompson, Leslie M.

J Neurosci Res ; 97(12): 1748, 2019 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-31612586

18.

Disease related changes in ATAC-seq of iPSC-derived motor neuron lines from ALS patients and controls.

Tsitkov, Stanislav; Valentine, Kelsey; Kozareva, Velina; Donde, Aneesh; Frank, Aaron; Lei, Susan; E Van Eyk, Jennifer; Finkbeiner, Steve; Rothstein, Jeffrey D; Thompson, Leslie M; Sareen, Dhruv; Svendsen, Clive N; Fraenkel, Ernest.

Nat Commun ; 15(1): 3606, 2024 May 02.

Artigo em Inglês | MEDLINE | ID: mdl-38697975

19.

Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models.

Sontag, Emily Mitchell; Lotz, Gregor P; Agrawal, Namita; Tran, Andrew; Aron, Rebecca; Yang, Guocheng; Necula, Mihaela; Lau, Alice; Finkbeiner, Steven; Glabe, Charles; Marsh, J Lawrence; Muchowski, Paul J; Thompson, Leslie M.

J Neurosci ; 32(32): 11109-19, 2012 Aug 08.

Artigo em Inglês | MEDLINE | ID: mdl-22875942

20.

Dithiol-based compounds maintain expression of antioxidant protein peroxiredoxin 1 that counteracts toxicity of mutant huntingtin.

Pitts, Andrea; Dailey, Kyle; Newington, Jordan T; Chien, Andrew; Arseneault, Robert; Cann, Tyler; Thompson, Leslie M; Cumming, Robert C.

J Biol Chem ; 287(27): 22717-29, 2012 Jun 29.

Artigo em Inglês | MEDLINE | ID: mdl-22577145

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